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Document and Entity Information - shares	3 Months Ended
Document and Entity Information - shares	Mar. 31, 2017	May 12, 2017
Document and Entity Information [Abstract]
Entity Registrant Name	Cyclacel Pharmaceuticals, Inc.
Entity Central Index Key	0001130166
Trading Symbol	cycc
Current Fiscal Year End Date	--12-31
Entity Filer Category	Smaller Reporting Company
Entity Common Stock, Shares Outstanding		4,272,947
Document Type	10-Q
Document Period End Date	Mar. 31, 2017
Amendment Flag	false
Document Fiscal Year Focus	2017
Document Fiscal Period Focus	Q1

CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Mar. 31, 2017	Dec. 31, 2016
Current assets:
Cash and cash equivalents	$ 12,729	$ 16,520
Prepaid expenses and other current assets	4,305	3,097
Total current assets	17,034	19,617
Property, plant and equipment (net)	39	45
Total assets	17,073	19,662
Current liabilities:
Accounts payable	1,652	2,497
Accrued and other current liabilities	2,476	2,762
Total current liabilities	4,128	5,259
Other liabilities	127	130
Total liabilities	4,255	5,389
Commitments and contingencies
Stockholders' equity:
Preferred stock, $0.001 par value; 5,000,000 shares authorized at December 31, 2016 and March 31, 2017; 335,273 shares issued and outstanding at December 31, 2016 and March 31, 2017. Aggregate preference in liquidation of $4,006,512 at December 31, 2016 and March 31, 2017.
Common stock, $0.001 par value; 100,000,000 shares authorized at December 31, 2016 and March 31, 2017; 4,256,829 and 4,272,947 shares issued and outstanding at December 31, 2016 and March 31, 2017 respectively.	4	4
Additional paid-in capital	350,156	350,051
Accumulated other comprehensive loss	(748)	(743)
Accumulated deficit	(336,594)	(335,039)
Total stockholders' equity	12,818	14,273
Total liabilities and stockholders' equity	$ 17,073	$ 19,662

CONSOLIDATED BALANCE SHEETS (Parentheticals) - USD ($) $ in Thousands	Mar. 31, 2017	Dec. 31, 2016
CONSOLIDATED BALANCE SHEETS
Preferred stock, par value (in dollars per share)	$ 0.001	$ 0.001
Preferred stock, shares authorized	5,000,000	5,000,000
Preferred stock, shares issued	335,273	335,273
Preferred stock, shares outstanding	335,273	335,273
Preferred stock, liquidation preference value (in dollars)	$ 4,006,512	$ 4,006,512
Common stock, par value (in dollars per share)	$ 0.001	$ 0.001
Common stock, shares authorized	100,000,000	100,000,000
Common stock, shares issued	4,272,947	4,256,829
Common stock, shares outstanding	4,272,947	4,256,829

CONSOLIDATED STATEMENTS OF OPERATIONS (Unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2017	Mar. 31, 2016
Revenues:
Grant revenue		$ 139
Total revenues		139
Operating expenses:
Research and development	$ 1,312	2,499
General and administrative	1,381	1,384
Total operating expenses	2,693	3,883
Operating loss	(2,693)	(3,744)
Other income (expense):
Foreign exchange gains (losses)	(59)	180
Interest income	12	10
Other income, net	879	20
Total other income, net	832	210
Loss before taxes	(1,861)	(3,534)
Income tax benefit	306	493
Net loss	(1,555)	(3,041)
Dividend on convertible exchangeable preferred shares	(50)	(50)
Net loss applicable to common stockholders	$ (1,605)	$ (3,091)
Basic and diluted earnings per common share:
Net loss per share - basic and diluted (in dollars per share)	$ (0.38)	$ (1.04)
Weighted average common shares outstanding (in shares)	4,271,324	2,965,208

CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS (Unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2017	Mar. 31, 2016
CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS
Net loss	$ (1,555)	$ (3,041)
Translation adjustment	(1,940)	4,295
Unrealized foreign exchange gain on intercompany loans	1,935	(4,361)
Comprehensive loss	$ (1,560)	$ (3,107)

CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2017	Mar. 31, 2016
Operating activities:
Net loss	$ (1,555)	$ (3,041)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation	9	42
Stock-based compensation	69	221
Changes in operating assets and liabilities:
Prepaid expenses and other assets	(1,137)	(182)
Accounts payable and other current liabilities	(1,196)	(187)
Net cash used in operating activities	(3,810)	(3,147)
Investing activities:
Purchase of property, plant and equipment	(2)
Net cash used in investing activities	(2)
Financing activities:
Proceeds from issuance of common stock, net of issuance costs	86
Payment of preferred stock dividend	(50)	(50)
Net cash used in financing activities	36	(50)
Effect of exchange rate changes on cash and cash equivalents	(15)	(128)
Net increase / (decrease) in cash and cash equivalents	(3,791)	(3,325)
Cash and cash equivalents, beginning of period	16,520	20,440
Cash and cash equivalents, end of period	12,729	17,115
Cash received during the period for:
Interest	12	10
Taxes	8
Non cash financing activities:
Accrual of preferred stock dividends	$ 50	$ 50

Summary of Significant Accounting Policies

3 Months Ended

Mar. 31, 2017

Accounting Policies [Abstract]

Summary of Significant Accounting Policies

2.	Summary of Significant Accounting Policies

Basis of Presentation

The consolidated balance sheet as of March 31, 2017, the consolidated statements of operations, comprehensive loss and cash flows for the three months ended March 31, 2017 and 2016, and all related disclosures contained in the accompanying notes are unaudited. The consolidated balance sheet as of December 31, 2016 is derived from the audited consolidated financial statements included in the Annual Report on Form 10-K for the fiscal year ended December 31, 2016 filed with the Securities and Exchange Commission (“SEC”). The consolidated financial statements are presented on the basis of accounting principles that are generally accepted in the United States (“GAAP”) for interim financial information and in accordance with the rules and regulations of the SEC. Accordingly, they do not include all the information and footnotes required by accounting principles generally accepted in the United States for a complete set of financial statements. In the opinion of management, all adjustments, which include only normal recurring adjustments necessary to present fairly the consolidated balance sheet as of March 31, 2017, and the results of operations, comprehensive loss and cash flows for the three months ended March 31, 2017, have been made. The interim results for the three months ended March 31, 2017 are not necessarily indicative of the results to be expected for the year ending December 31, 2017 or for any other year. The consolidated financial statements should be read in conjunction with the audited consolidated financial statements and the accompanying notes for the year ended December 31, 2016 that are included in the Company’s Annual Report on Form 10-K filed with the SEC.

Use of Estimates

The preparation of financial statements in accordance with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities and related disclosures of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Critical estimates include inputs used to determine clinical trial accruals, research and development expenditures, stock-based compensation expense and the recognition of revenue, which Cyclacel reviews on an on going basis. The estimates are based on historical experience and on various other assumptions that the Company believes to be reasonable under the circumstances. Actual results may differ from these estimates. Cyclacel believes the judgments and estimates required by the following accounting policies to be significant in the preparation of the Company’s consolidated financial statements.

Risks and Uncertainties

Drug candidates developed by the Company typically will require approvals or clearances from the Food and Drug Administration (“FDA”), European Medicines Agency (“EMA”) or other international regulatory agencies prior to commercial sales. There can be no assurance that the Company’s drug candidates will receive any of the required approvals or clearances. If the Company was denied approval or clearance or such approval was delayed, or is unable to obtain the necessary financing to complete development and approval, there will be a material adverse impact on the Company’s financial condition and results of operations. The Company has relied upon government grants to fund its earlier stage programs and does not expect to be able to continue to be successful in obtaining government grants to fund the Company’s research and development activities.

Going Concern

Management considers that there are no conditions or events, in the aggregate, that raise substantial doubt about the entity’s ability to continue as a going concern for a period of at least one year from the date the financial statements are issued. The Company expects that its cash of $12.7 million as of March 31, 2017 will be sufficient to fund its operating expenses and capital expenditure requirements through to the end of 2018.

This evaluation is based on relevant conditions and events that are known and reasonably knowable at the date that the financial statements are issued, including:

The Company’s current financial condition, including its liquidity sources

The Company’s conditional and unconditional obligations due or anticipated within one year

The funds necessary to maintain the Company’s operations considering its current financial condition, obligations, and other expected cash flows, and

Other conditions and events, when considered in conjunction with the above that may adversely affect the Company’s ability to meet its obligations.

The future viability of the Company beyond the end of 2018 is dependent on its ability to raise additional capital to finance its operations. The Company will need to raise substantial additional capital to pursue the transcriptional regulation program, evaluating CYC065, a CDK inhibitor, in patients with advanced cancers or the DNA damage response program, evaluating a sequential regimen of sapacitabine and seliciclib, a CDK inhibitor, in patients with BRCA positive, advanced solid cancers Additional funding may not be available to the Company on favorable terms, or at all. If the Company is unable to obtain additional funds, it will need to reduce operating expenses, enter into a collaboration or other similar arrangement with respect to development and/or commercialization rights to sapacitabine or its CDK inhibitors, if available, or be forced to delay or reduce the scope of its CDK inhibitors and sapacitabine development programs, including any potential regulatory filings related to the SEAMLESS study, and/or limit or cease its operations. The Company’s inability to raise capital as and when needed could have a negative impact on its financial condition and ability to pursue its business strategies.

Segments

The Company is managed and operated as one business which is focused on using cell cycle, transcriptional regulation and DNA damage response biology to develop innovative, targeted medicines for cancer and other proliferative diseases .The entire business is managed by a single management team that reports to the Chief Executive Officer. The Company does not operate separate lines of business with respect to any of its products or product candidates and the Company does not prepare discrete financial information with respect to separate products or product candidates or by location. Accordingly, the Company views its business as one reportable operating segment with development operations in two geographic areas, namely the United States and the United Kingdom.

Cash and Cash Equivalents

The Company considers all highly liquid investments with an original maturity of three months or less at the time of initial purchase to be cash equivalents. The objectives of the Company’s cash management policy are to safeguard and preserve funds, to maintain liquidity sufficient to meet Cyclacel’s cash flow requirements and to attain a market rate of return.

The Company’s cash and cash equivalents balance at March 31, 2017 was $12.7 million and it maintains its cash accounts in several entities both within the United States and the United Kingdom. The total cash balances for amounts held in the United States are insured by the Federal Deposit Insurance Corporation (“FDIC”) up to $250,000 per account. The Company has cash balances exceeding the balance insured by the FDIC that totaled approximately $11.6 million at March 31, 2017. The total cash balances for amounts held in the United Kingdom are insured by the UK Government Financial Services Compensation Scheme (“FSCS”) up to £75,000 per account. The Company has cash balances exceeding the balance insured by the FSCS that totaled approximately $0.8 million at March 31, 2017.

Fair Value of Financial Instruments

Financial instruments consist of cash equivalents, accounts payable and accrued liabilities. The carrying amounts of cash equivalents, accounts payable and accrued liabilities approximate their respective fair values due to the nature of the accounts, notably their short maturities.

Comprehensive Income (Loss)

All components of comprehensive income (loss), including net income (loss), are reported in the financial statements in the period in which they are recognized. Comprehensive income (loss) is defined as the change in equity during a period from transactions and other events and circumstances from non-owner sources. Net income (loss) and other comprehensive income (loss), including foreign currency translation adjustments, are reported, net of any related tax effect, to arrive at comprehensive income (loss). No taxes were recorded on items of other comprehensive income (loss). There were no reclassifications out of other comprehensive income (loss) during the three months ended March 31, 2016 and 2017.

Recently Issued Accounting Pronouncements

In October 2016, the FASB issued ASU No. 2016-16, Income Taxes (Topic 740): Intra-Entity Transfer of Assets Other than Inventory (‘‘ASU 2016-16’’), which requires the recognition of the income tax consequences of an intra-entity transfer of an asset, other than inventory, when the transfer occurs. The standard is effective for annual periods beginning after December 15, 2017, including interim periods within those fiscal years. The Company anticipates this standard will not have a material impact on its consolidated financial statements.

In August 2016, the FASB issued ASU No. 2016-15, Statement of Cash Flows: Classification of Certain Cash Receipts and Cash Payments (“ASU 2016-15”), to address diversity in practice in how certain cash receipts and cash payments are presented and classified in the statement of cash flows. The standard is effective for annual periods beginning after December 15, 2017, including interim periods within those fiscal years. The Company anticipates this standard will not have a material impact on its consolidated financial statements.

In February 2016, the FASB issued guidance on accounting for leases in ASU No, 2016-02. The guidance requires that lessees recognize a lease liability, which is a lessee’s obligation to make lease payments arising from a lease, measured on a discounted basis; and a right-of-use asset, which is an asset that represents the lessee’s right to use, or control the use of, a specified asset for the lease term at the commencement date. The guidance is effective for fiscal years beginning after December 15, 2018. Early application is permitted. The guidance must be adopted on a modified retrospective transition approach for leases existing, or entered into after, the beginning of the earliest comparative period presented in the financial statements. The Company is currently evaluating the impact of the guidance on the consolidated financial statements.

In May 2014, the FASB issued ASU No. 2014-09, Revenue from Contracts with Customers (Topic 606) (‘‘ASU 2014-09’’), which supersedes existing revenue recognition guidance. The standard’s core principle is that a company will recognize revenue when it transfers promised goods or services to customers in an amount that reflects the consideration to which the Company expects to be entitled in exchange for those goods or services. The standard defines a five-step process to achieve this principle; (1) identify the contract with a customer; (2) identify the performance obligations in the contract; (3) determine the transaction price; (4) allocate the transaction price to the performance obligations in the contract; and (5) recognize revenue when, or as, the Company satisfies a performance obligation. ASU 2014-09 also requires additional disclosure about the nature, amount, timing and uncertainty of revenue and cash flows arising from customer contracts. The guidance is effective for annual periods beginning after December 15, 2017 and for interim periods within those fiscal years. ASU 2014-09 was amended by multiple accounting standards updates from 2014-2016.

The Company anticipates this standard will not have a material impact on its consolidated financial statements. While the Company is continuing to assess all potential impacts of the standard, the Company currently believes the most significant impact relates to its accounting for revenues related to grants received from government agencies or nonprofit organizations and revenues from contingent “milestone” based payments. Under the new standard the Company expects to report grant revenue, if new grants are obtained, in other income or as a contra against expenses. Historically grants have been reported in revenue, but as the grantor is not likely to be receiving a good or service in exchange for the payment the grant cannot be reported in revenue. The Company also expects to recognize revenue associated with contingent milestone-based payments at the time the contingent event is highly probable to be met, rather than when the milestone is achieved. However, given the limited number of potential milestones owed to Cyclacel, and the inherent risk involved in developing drugs, the milestones are unlikely to be impacted. The guidance permits two methods of adoption: retrospectively to each prior reporting period presented (full retrospective method), or retrospectively with the cumulative effect of initially applying the guidance recognized at the date of initial application (the modified retrospective method). The Company currently intends to use the modified retrospective method when it adopts the new accounting standard.

Stock Based Compensation

3 Months Ended

Mar. 31, 2017

Disclosure Of Compensation Related Costs Share-Based Payments [Abstract]

Stock Based Compensation

Stock Based Compensation

ASC 718 requires compensation expense associated with share-based awards to be recognized over the requisite service period, which for the Company is the period between the grant date and the date the award vests or becomes exercisable. Most of the awards granted by the Company (and still outstanding) vest ratably over one to four years. The Company recognizes all share-based awards under the straight-line attribution method, assuming that all granted awards will vest. Forfeitures will be recognized in the periods when they occur.

Stock based compensation has been reported within expense line items on the consolidated statement of operations for the three months ended March 31, 2016 and 2017 as shown in the following table (in $000s):

	Three Months Ended March 31,
	2016		2017
General and administrative	$	142	$	50
Research and development		79		19
Stock-based compensation costs before income taxes	$	221	$	69

2015 Plan

On May 22, 2015, the Company’s stockholders approved the 2015 Equity Incentive Plan (the “2015 Plan”), under which Cyclacel may make equity incentive grants to its officers, employees, directors and consultants. The company has reserved 291,667 shares of the Company’s common stock under the 2015 Plan. The 2015 Plan replaces the 2006 Equity Incentive Plan (the “2006 Plan”), under which there were no remaining reserved shares to be granted. Stock option awards granted under the Company’s equity incentive plans have a maximum life of 10 years and generally vest over a one to four-year period from the date of grant.

There were no options granted during the three months ended March 31, 2017.

In 2016, 189,091 options were granted that are performance based. These options will vest upon the fulfillment of certain clinical conditions and will terminate if they have not vested by December 31, 2020. The Company determined that the satisfaction of the vesting criteria was not probable as of March 31, 2017 and, as a result, did not record any expense related to these awards for the three months ended March 31, 2017.

There were no stock options exercised during each of the three months ended March 31, 2016 and 2017, respectively. The Company does not expect to be able to benefit from the deduction for stock option exercises that may occur during the year ended December 31, 2017 because the company has tax loss carryforwards from prior periods that would be expected to offset any potential taxable income for the year ended December 31, 2017.

Outstanding Options

A summary of the share option activity and related information is as follows:

	Number of Options Outstanding			Weighted Average Exercise Price Per Share		Weighted Average Remaining Contractual Term (Years)		Aggregate Intrinsic Value ($000)
Options outstanding at December 31, 2016		389,379			25.80		5.83		121
Granted		-			-
Cancelled/forfeited		(1,860	)		655.18
Options outstanding at March 31, 2017		387,519			22.78		5.61		—
Unvested at March 31, 2017		(258,124	)		5.28		5.08		—
Vested and exercisable at March 31, 2017		129,395			57.68		6.68		—

The fair value of the stock options granted is calculated using the Black-Scholes option-pricing model as prescribed by ASC 718.

- Definition

The entire disclosure for compensation-related costs for equity-based compensation, which may include disclosure of policies, compensation plan details, allocation of equity compensation, incentive distributions, equity-based arrangements to obtain goods and services, deferred compensation arrangements, employee stock ownership plan details and employee stock purchase plan details.

+ References + Details

Stockholders Equity

3 Months Ended

Mar. 31, 2017

Stockholders' Equity Note [Abstract]

Stockholders Equity

8.	Stockholders Equity

Preferred Stock

As of March 31, 2017, there were 335,273 shares of the Company’s 6% Convertible Exchangeable Preferred Stock (“Preferred Stock”) issued and outstanding at an issue price of $10.00 per share. Dividends on the Preferred Stock are cumulative from the date of original issuance at the annual rate of 6% of the liquidation preference of the Preferred Stock, payable quarterly on the first day of February, May, August and November, commencing February 1, 2005. Any dividends must be declared by the Company’s Board and must come from funds that are legally available for dividend payments. The Preferred Stock has a liquidation preference of $10.00 per share, plus accrued and unpaid dividends.

The Preferred Stock is convertible at the option of the holder at any time into the Company’s shares of common stock at a conversion rate of approximately 0.00507 shares of common stock for each share of Preferred Stock based on a price of $1,974. The Company has reserved 1,698 shares of common stock for issuance upon conversion of the remaining shares of Preferred Stock outstanding at March 31, 2017. The shares of previously-converted Preferred Stock have been retired, cancelled and restored to the status of authorized but unissued shares of preferred stock, subject to reissuance by the Board of Directors as shares of Preferred Stock of one or more series.

The Company may automatically convert the Preferred Stock into common stock if the closing price of the Company’s common stock has exceeded $2,961, which is 150% of the conversion price of the Preferred Stock, for at least 20 trading days during any 30-day trading period, ending within five trading days prior to notice of automatic conversion.

The Preferred Stock has no maturity date and no voting rights prior to conversion into common stock, except under limited circumstances.

The Company may, at its option, redeem the Preferred Stock in whole or in part, out of funds legally available at the redemption price of $10.00 per share.

The Preferred Stock is exchangeable, in whole but not in part, at the option of the Company on any dividend payment date beginning on November 1, 2005 (the “Exchange Date”) for the Company’s 6% Convertible Subordinated Debentures (“Debentures”) at the rate of $10.00 principal amount of Debentures for each share of Preferred Stock. The Debentures, if issued, will mature 25 years after the Exchange Date and have terms substantially similar to those of the Preferred Stock. No such exchanges have taken place to date.

On March 7, 2017, the Board declared a quarterly cash dividend in the amount of $0.15 per share on the Company’s 6% Convertible Exchangeable Preferred Stock (“Preferred Stock”). The cash dividend was paid on May 1, 2017 to the holders of record of the Preferred Stock as of the close of business on April 14, 2017.

Common Stock

June 2016 At Market Issuance

On June 23, 2016, the Company entered into a sales agreement with FBR (the “FBR Sales Agreement”), under which the Company may issue and sell shares of its common stock, from time to time through FBR, acting as its sales agent. Under the FBR Sales Agreement, FBR may sell the shares of common stock by any method that is deemed to be an “at the market offering”. The Company will pay FBR a commission of 3.0% of the gross sales price per share sold. The Company is not obligated to make any sales of common stock under the FBR Sales Agreement. In the three months ended March 31, 2017, the Company sold 16,118 shares of common stock under the sales agreement for net proceeds of approximately $0.1 million.

During April 2017, the Company sold a further 167,000 shares of common stock for net proceeds of approximately $1.0 million.

- Definition

The entire disclosure for shareholders' equity comprised of portions attributable to the parent entity and noncontrolling interest, including other comprehensive income. Includes, but is not limited to, balances of common stock, preferred stock, additional paid-in capital, other capital and retained earnings, accumulated balance for each classification of other comprehensive income and amount of comprehensive income.

+ References

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+ Details

Summary of Significant Accounting Policies (Policies)

3 Months Ended

Mar. 31, 2017

Accounting Policies [Abstract]

Basis of Presentation

Basis of Presentation

Use of Estimates

Use of Estimates

Risks and Uncertainties

Risks and Uncertainties

Going Concern

Going Concern

This evaluation is based on relevant conditions and events that are known and reasonably knowable at the date that the financial statements are issued, including:

The Company’s current financial condition, including its liquidity sources

The Company’s conditional and unconditional obligations due or anticipated within one year

The funds necessary to maintain the Company’s operations considering its current financial condition, obligations, and other expected cash flows, and

Other conditions and events, when considered in conjunction with the above that may adversely affect the Company’s ability to meet its obligations.

Segments

Segments

Cash and Cash Equivalents

Cash and Cash Equivalents

Fair Value of Financial Instruments

Fair Value of Financial Instruments

Comprehensive Income (Loss)

Comprehensive Income (Loss)

Recently Issued Accounting Pronouncements

Recently Issued Accounting Pronouncements

Summary of Significant Accounting Policies (Detail Textuals)	3 Months Ended
	Mar. 31, 2017 USD ($) Segment	Mar. 31, 2017 GBP (£) Segment	Dec. 31, 2016 USD ($)	Mar. 31, 2016 USD ($)	Dec. 31, 2015 USD ($)
Accounting Policies [Abstract]
Cash and cash equivalents	$ 12,729,000		$ 16,520,000	$ 17,115,000	$ 20,440,000
Number of operating segments \| Segment	1
Number of geographic areas for development operations \| Segment	2	2
Cash balances insured by FDIC	$ 250,000
Cash exceeding balance insured by FDIC	11,600,000
Cash insured by the financial services compensation scheme \| £		£ 75,000
Cash Exceeding Balance Insured By Financia Lservices Compensation Scheme	$ 800,000

Prepaid Expenses and Other Current Assets (Details) - USD ($) $ in Thousands	Mar. 31, 2017	Dec. 31, 2016
Prepaid Expense and Other Assets, Current [Abstract]
Research and development tax credit receivable	$ 2,053	$ 1,730
Prepayments	705	867
Accounts receivable	879	10
Other taxes receivable	399	327
Deposits	132	132
Other current assets	137	31
Prepaid expenses and other current assets	$ 4,305	$ 3,097

Accrued and Other Liabilities (Details) - USD ($) $ in Thousands	Mar. 31, 2017	Dec. 31, 2016
Payables And Accruals [Abstract]
Accrued research and development	$ 1,855	$ 2,138
Accrued legal and professional fees	271	194
Other current liabilities	350	430
Total	$ 2,476	$ 2,762

Stock Based Compensation (Details 1) - Stock options - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended	12 Months Ended
	Mar. 31, 2017	Dec. 31, 2016
Number of Options Outstanding
Options outstanding at December 31, 2016	389,379
Granted
Cancelled/forfeited	(1,860)
Options outstanding at March 31, 2017	387,519	389,379
Unvested at March 31, 2017	(258,124)
Vested and exercisable at March 31, 2017	129,395
Weighted Average Exercise Price Per Share
Options outstanding at December 31, 2016	$ 25.80
Granted
Cancelled/forfeited	655.18
Options outstanding at March 31, 2017	22.78	$ 25.80
Unvested at March 31, 2017	5.28
Vested and exercisable at March 31, 2017	$ 57.68
Weighted Average Remaining Contractual Term (Years)
Options outstanding	5 years 7 months 10 days	5 years 9 months 29 days
Unvested at March 31, 2017	5 years 29 days
Vested and exercisable at March 31, 2017	6 years 8 months 5 days
Aggregate Intrinsic Value
Options outstanding		$ 121
Unvested at March 31, 2017
Vested and exercisable at March 31, 2017

Stock Based Compensation (Detail Textuals) - shares	1 Months Ended	3 Months Ended	12 Months Ended
Stock Based Compensation (Detail Textuals) - shares	May 22, 2015	Mar. 31, 2017	Dec. 31, 2016
Stock options
Stock-based compensation
Options granted (in shares)
Stock options \| 2015 plan
Stock-based compensation
Number of shares reserved for issuance	291,667
Expiration period	10 years
Stock options \| 2015 plan \| Minimum
Stock-based compensation
Vesting period	1 year
Stock options \| 2015 plan \| Maximum
Stock-based compensation
Vesting period	4 years
Performance based share \| 2015 plan
Stock-based compensation
Options granted (in shares)			189,091

Stockholders Equity (Detail Textuals)		3 Months Ended
Stockholders Equity (Detail Textuals)	Mar. 07, 2017 $ / shares	Mar. 31, 2017 Conversion_rate Series $ / shares shares	Dec. 31, 2016 $ / shares shares
Stockholders' equity
Preferred stock, shares issued \| shares		335,273	335,273
Preferred stock, shares outstanding \| shares		335,273	335,273
Preferred stock, par value (in dollars per share)		$ 0.001	$ 0.001
Convertible Exchangeable Preferred Stock
Stockholders' equity
Preferred stock, shares issued \| shares		335,273
Preferred stock, shares outstanding \| shares		335,273
Share issue price per share		$ 10.00
Dividend rate on convertible exchangeable preferred stock (in percent)	6.00%	6.00%
Liquidation preference (in dollars per share)		$ 10.00
Number of shares to be issued for each preferred stock upon conversion \| Conversion_rate		0.00507
Conversion price (in dollars per share)		$ 1,974
Common stock shares reserved for future issuance upon conversion \| shares		1,698
Number of series of Preferred Stock \| Series		1
Minimum bid price per share		$ 2,961
Percentage of the closing sales price of the entity's common stock that the conversion price must exceed in order for the preferred stock to be convertible		150.00%
Number of trading days within 30 trading days in which the closing price of the entity's common stock must exceed the conversion price for the preferred stock to be convertible		20 days
Number of trading days during which the closing price of the entity's common stock must exceed the conversion price for at least 20 days in order for the preferred stock to be convertible		30 days
Number of trading days prior to notice of automatic conversion		5 days
Redemption price per share (in dollars per share)		$ 10.00
Interest rate (as a percent)		6.00%
Debt principal amount per share, basis for exchange (in dollars per share)		$ 10.00
Debt instrument, term		25 years
Preferred stock dividend declared, amount per share	$ 0.15
Dividend paid, date	May 01, 2017
Dividend, record date	Apr. 14, 2017

Stockholders Equity (Detail Textuals 1) - USD ($) $ in Thousands	1 Months Ended		3 Months Ended
	Apr. 30, 2017	Jun. 23, 2016	Mar. 31, 2017
Nature Of Operations And Basis Of Presentation [Line Items]
Proceeds from issuance of common stock			$ 86
FBR Sales Agreement
Nature Of Operations And Basis Of Presentation [Line Items]
Percentage of commission on gross equity sales		3.00%
Number of common shares sold into underwriting agreement (in shares)		16,118
Sale of stock, value		$ 100
FBR Sales Agreement \| Subsequent event
Nature Of Operations And Basis Of Presentation [Line Items]
Number of common shares sold into underwriting agreement (in shares)	167,000
Sale of stock, value	$ 1,000

Net Loss Per Common Share (Details) - shares	3 Months Ended
Net Loss Per Common Share (Details) - shares	Mar. 31, 2017	Mar. 31, 2016
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total shares excluded from calculation	389,217	423,816
Stock options
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total shares excluded from calculation	387,519	376,775
Convertible preferred stock
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total shares excluded from calculation	1,698	1,698
Common stock warrants
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total shares excluded from calculation		45,343

Commitments and Contingencies (Details) - Daiichi Sankyo $ in Millions	3 Months Ended
	Mar. 31, 2017 USD ($)
Supply Commitment [Line Items]
Future milestone payments payable	$ 10.0
Period for which royalties will be paid following first commercial sale of licensed products	10 years
Notice period for termination of license by the entity for technical, scientific, efficacy, safety, or commercial reasons	6 months
Notice period for termination of license after launch of a sapacitabine-based product by the entity, or by either party for material default	12 months

Stock Based Compensation (Details) - USD ($) $ in Thousands	3 Months Ended
Stock Based Compensation (Details) - USD ($) $ in Thousands	Mar. 31, 2017	Mar. 31, 2016
Stock-based compensation
Stock-based compensation costs before income taxes	$ 69	$ 221
General and administrative
Stock-based compensation
Stock-based compensation costs before income taxes	50	142
Research and development
Stock-based compensation
Stock-based compensation costs before income taxes	$ 19	$ 79