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Document and Entity Information - USD ($)	12 Months Ended
Document and Entity Information - USD ($)	Dec. 31, 2012	Mar. 29, 2013	Jun. 30, 2012
Document and Entity Information
Entity Registrant Name	Cyclacel Pharmaceuticals, Inc.
Entity Central Index Key	0001130166
Document Type	10-K
Document Period End Date	Dec. 31, 2012
Amendment Flag	false
Current Fiscal Year End Date	--12-31
Entity Well-known Seasoned Issuer	No
Entity Voluntary Filers	No
Entity Current Reporting Status	Yes
Entity Filer Category	Smaller Reporting Company
Entity Public Float			$ 27,140,565
Entity Common Stock, Shares Outstanding		10,831,779
Document Fiscal Year Focus	2012
Document Fiscal Period Focus	FY

CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Dec. 31, 2012	Dec. 31, 2011
Current assets:
Cash and cash equivalents	$ 16,412	$ 24,449
Prepaid expenses and other current assets	1,599	1,069
Current assets of discontinued operations	861	313
Total current assets	18,872	25,831
Property, plant and equipment (net)	129	167
Long-term assets of discontinued operations	353
Total assets	19,354	25,998
Current liabilities:
Accounts payable	2,259	1,717
Accrued and other current liabilities	5,601	4,183
Economic Rights measured at fair value	1,120
Other liabilities measured at fair value	20	71
Current liabilities of discontinued operations	335	527
Total current liabilities	9,335	6,498
Total liabilities	9,335	6,498
Commitments and contingencies
Stockholders' equity:
Preferred stock, $0.001 par value; 5,000,000 shares authorized at December 31, 2011 and 2012; 1,213,142 shares issued and outstanding at December 31, 2011 and 2012. Aggregate preference in liquidation of $13,708,505 and $14,436,390 at December 31, 2011 and December 31, 2012, respectively	1	1
Common stock, $0.001 par value; 100,000,000 shares authorized at December 31, 2011 and 2012; 7,745,780 and 8,686,484 shares issued and outstanding at December 31, 2011 and 2012, respectively	9	8
Additional paid-in capital	280,211	276,498
Accumulated other comprehensive income	48	57
Deficit accumulated during the development stage	(270,250)	(257,064)
Total stockholders' equity	10,019	19,500
Total liabilities and stockholders' equity	$ 19,354	$ 25,998

CONSOLIDATED BALANCE SHEETS (Parenthetical) - USD ($) $ in Thousands	Dec. 31, 2012	Dec. 31, 2011
CONSOLIDATED BALANCE SHEETS
Preferred stock, par value (in dollars per share)	$ 0.001	$ 0.001
Preferred stock, shares authorized	5,000,000	5,000,000
Preferred stock, shares issued	1,213,142	1,213,142
Preferred stock, shares outstanding	1,213,142	1,213,142
Preferred stock, liquidation preference value (in dollars)	$ 14,436,390	$ 13,708,505
Common stock, par value (in dollars per share)	$ 0.001	$ 0.001
Common stock, shares authorized	100,000,000	100,000,000
Common stock, shares issued	8,686,484	7,745,780
Common stock, shares outstanding	8,686,484	7,745,780

CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) $ in Thousands	12 Months Ended			197 Months Ended
	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2012
Revenues:
Collaboration and research and development revenue			$ 100	$ 3,100
Grant revenue	$ 69		12	3,717
Total revenues	69		112	6,817
Operating expenses:
Research and development	6,592	$ 9,206	6,414	192,391
General and administrative	8,580	6,542	8,833	89,411
Goodwill and intangibles impairment				2,747
Other restructuring costs				2,634
Total operating expenses	15,172	15,748	15,247	287,183
Operating loss	(15,103)	(15,748)	(15,135)	(280,366)
Other income (expense):
Costs associated with aborted 2004 IPO				(3,550)
Payment under guarantee				(1,652)
Non-cash consideration associated with stock purchase agreement	(423)			(423)
Change in valuation of Economic Rights	(23)			(23)
Change in valuation of liabilities measured at fair value	51	609	(338)	6,378
Foreign exchange losses	292	(74)	(68)	(4,005)
Interest income	22	45	37	13,747
Interest expense			(43)	(4,567)
Other income (expense)	77			77
Total other (expense) income, net	(4)	580	(412)	5,982
(Loss) income from continuing operations before taxes	(15,107)	(15,168)	(15,547)	(274,384)
Income tax benefit	1,351	565	657	19,795
Net loss from continuing operations	(13,756)	(14,603)	(14,890)	(254,589)
Discontinued operations:
(Loss) income from discontinued operations, net of tax of $0, $0 and $(337) for the years ended December 31, 2010, 2011 and 2012, respectively	570	(640)	(1,131)	(12,146)
Net loss	(13,186)	(15,243)	(16,021)	(266,735)
Dividend on preferred ordinary shares				(38,123)
Deemed dividend on convertible exchangeable preferred shares			(3,515)	(3,515)
Dividend on convertible exchangeable preferred shares	(728)	(728)	(167)	(4,385)
Net loss applicable to common shareholders	$ (13,914)	$ (15,971)	$ (19,703)	$ (312,758)
Net loss per share, continuing operations - basic and diluted (in dollars per share)	$ (1.75)	$ (2.13)	$ (3.43)
Net loss per share, discontinued operations - basic and diluted (in dollars per share)	0.07	(0.09)	(0.21)
Net loss per share - basic and diluted (in dollars per share)	$ (1.68)	$ (2.22)	$ (3.64)
Weighted average common shares outstanding (in shares)	8,291,802	7,185,877	5,406,385

CONSOLIDATED STATEMENTS OF OPERATIONS (Parenthetical) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
CONSOLIDATED STATEMENTS OF OPERATIONS
(Loss) income from discontinued operations, tax	$ (337)	$ 0	$ 0

- Definition

Tax effect allocated to a disposal group that is classified as a component of the entity reported as a separate component of income before extraordinary items. Includes the tax effects of the following: income (loss) from operations during the phase-out period, gain (loss) on disposal, provision (or any reversals of earlier provisions) for loss on disposal, and adjustments of a prior period gain (loss) on disposal.

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CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS - USD ($) $ in Thousands	8 Months Ended	9 Months Ended	12 Months Ended															185 Months Ended	194 Months Ended	197 Months Ended
	Mar. 31, 1997	Dec. 31, 2003	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009	Dec. 31, 2008	Dec. 31, 2007	Dec. 31, 2006	Dec. 31, 2005	Dec. 31, 2004	Mar. 31, 2003	Mar. 31, 2002	Mar. 31, 2001	Mar. 31, 2000	Mar. 31, 1999	Mar. 31, 1998	Dec. 31, 2011	Sep. 30, 2012	Dec. 31, 2012
CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS
Net loss from continuing operations			$ (13,756)	$ (14,603)	$ (14,890)															$ (254,589)
(Loss) income from discontinued operations, net of tax			570	(640)	(1,131)															(12,146)
Net loss	$ (290)	$ (14,977)	(13,186)	(15,243)	(16,021)	$ (19,570)	$ (40,386)	$ (24,053)	$ (29,258)	$ (18,048)	$ (22,742)	$ (15,542)	$ (14,853)	$ (10,382)	$ (5,686)	$ (3,964)	$ (2,534)	$ (253,549)	$ (261,971)	(266,735)
Translation adjustment	(4)	(1,343)	(4,559)	648	(2,084)	(5,589)	14,918	(93)	416	(1,786)	2,424	(1,846)	191	(466)	(194)	11	55	5,274		715
Unrealized foreign exchange gain (loss) on intercompany loans			4,550	(622)	2,073	5,651	(12,330)											(5,217)		(667)
Comprehensive loss	$ (294)	$ (16,320)	$ (13,195)	$ (15,217)	$ (16,010)	$ (19,508)	$ (37,798)	$ (24,146)	$ (28,842)	$ (19,834)	$ (20,318)	$ (17,388)	$ (14,662)	$ (10,848)	$ (5,880)	$ (3,953)	$ (2,479)	$ (253,492)		$ (266,687)

- Definition

Amount of income (loss) from continuing operations attributable to the parent. Also defined as revenue less expenses and taxes from ongoing operations before extraordinary items but after deduction of those portions of income or loss from continuing operations that are allocable to noncontrolling interests.

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- Definition

Amount of income (loss) from a disposal group, net of income tax, reported as a separate component of income before extraordinary items after deduction or consideration of the amount allocable to noncontrolling interests. Includes, net of tax, income (loss) from operations during the phase-out period, gain (loss) on disposal, provision (or any reversals of earlier provisions) for loss on disposal, and adjustments of a prior period gain (loss) on disposal.

+ References + Details

- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

+ References

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+ Details

- Definition

Amount after tax and reclassification adjustments, resulting from the process of expressing in the reporting currency of the reporting entity those amounts that are denominated or measured in a different currency, and from transactions whose terms are denominated in a currency other than the entity's functional currency, which is attributable to the parent entity.

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- Definition

Net of tax amount of other comprehensive income (loss) attributable to the parent entity.

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+ Details

CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (DEFICIT) - USD ($)	Total	Preferred Stock	Common stock	Additional paid-in capital	Accumulated other comprehensive income/(loss)	Deferred compensation	Deficit accumulated during development stage	Comprehensive loss
Balance at Mar. 31, 1997	$ (293,000)			$ 1,000	$ (4,000)		$ (290,000)
Increase (Decrease) in Stockholders' Equity
Issue of common stock for cash on registered direct offering, net of expenses	4,217,000			4,217,000
Issue of common stock for cash on registered direct offering, net of expenses (in shares)			38,111
Issue of shares for IP rights agreement, research & development agreement and license agreement	262,000			262,000
Stock-based compensation				2,002,000		$ (2,002,000)
Amortization of deferred stock-based compensation	302,000					302,000
Comprehensive loss:
Translation adjustment	55,000				55,000			$ 55,000
Loss for the year	(2,534,000)						(2,534,000)	(2,534,000)
Comprehensive loss	(2,479,000)							(2,479,000)
Balance at Mar. 31, 1998	2,009,000			6,482,000	51,000	(1,700,000)	(2,824,000)
Balance (in shares) at Mar. 31, 1998			38,111
Increase (Decrease) in Stockholders' Equity
Amortization of deferred stock-based compensation	406,000					406,000
Comprehensive loss:
Translation adjustment	11,000				11,000			11,000
Loss for the year	(3,964,000)						(3,964,000)	(3,964,000)
Comprehensive loss	(3,953,000)							(3,953,000)
Balance at Mar. 31, 1999	(1,538,000)			6,482,000	62,000	(1,294,000)	(6,788,000)
Balance (in shares) at Mar. 31, 1999			38,111
Increase (Decrease) in Stockholders' Equity
Issue of common stock for cash on registered direct offering, net of expenses	12,717,000			12,717,000
Issue of common stock for cash on registered direct offering, net of expenses (in shares)			76,984
Issue of shares on conversion of bridging loan and Loan Note Instrument	1,638,000			1,638,000
Issue of shares on conversion of bridging loan and Loan Note Instrument (in shares)			12,943
Issue of shares in lieu of cash bonus	164,000			164,000
Issue of shares in lieu of cash bonus (in shares)			1,294
Issue of shares for IP rights agreement, research & development agreement and license agreement	409,000			409,000
Issue of common stock upon exercise of stock options	40,000			40,000
Issue of common stock upon exercise of stock options (in shares)			324
Stock-based compensation				167,000		(167,000)
Amortization of deferred stock-based compensation	433,000					433,000
Comprehensive loss:
Translation adjustment	(194,000)				(194,000)			(194,000)
Loss for the year	(5,686,000)						(5,686,000)	(5,686,000)
Comprehensive loss	(5,880,000)							(5,880,000)
Balance at Mar. 31, 2000	7,983,000			21,617,000	(132,000)	(1,028,000)	(12,474,000)
Balance (in shares) at Mar. 31, 2000			129,656
Increase (Decrease) in Stockholders' Equity
Stock-based compensation				294,000		(294,000)
Amortization of deferred stock-based compensation	275,000					275,000
Comprehensive loss:
Translation adjustment	(466,000)				(466,000)			(466,000)
Loss for the year	(10,382,000)						(10,382,000)	(10,382,000)
Comprehensive loss	(10,848,000)							(10,848,000)
Balance at Mar. 31, 2001	(2,590,000)			21,911,000	(598,000)	(1,047,000)	(22,856,000)
Balance (in shares) at Mar. 31, 2001			129,656
Increase (Decrease) in Stockholders' Equity
Issue of common stock for cash on registered direct offering, net of expenses (in shares)			779
Issue of warrants in connection with registered direct offering	1,215,000			1,215,000
Issue of shares for IP rights agreement, research & development agreement and license agreement	183,000			183,000
Issue of shares for IP rights agreement, research & development agreement and license agreement (in shares)			644
Issue of common stock upon exercise of stock options	106,000			106,000
Stock-based compensation				363,000		(363,000)
Amortization of deferred stock-based compensation	672,000					672,000
Comprehensive loss:
Translation adjustment	191,000				191,000			191,000
Loss for the year	(14,853,000)						(14,853,000)	(14,853,000)
Comprehensive loss	(14,662,000)							(14,662,000)
Balance at Mar. 31, 2002	(15,076,000)			23,778,000	(407,000)	(738,000)	(37,709,000)
Balance (in shares) at Mar. 31, 2002			131,079
Increase (Decrease) in Stockholders' Equity
Issue of common stock upon exercise of stock options	12,000			12,000
Stock-based compensation				(84,000)		84,000
Amortization of deferred stock-based compensation	305,000					305,000
Comprehensive loss:
Translation adjustment	(1,846,000)				(1,846,000)			(1,846,000)
Loss for the year	(15,542,000)						(15,542,000)	(15,542,000)
Comprehensive loss	(17,388,000)							(17,388,000)
Balance at Mar. 31, 2003	(32,147,000)			23,706,000	(2,253,000)	(349,000)	(53,251,000)
Balance (in shares) at Mar. 31, 2003			131,079
Increase (Decrease) in Stockholders' Equity
Issue of common stock for cash on registered direct offering, net of expenses	27,635,000			27,635,000
Issue of common stock for cash on registered direct offering, net of expenses (in shares)			215,755
Preferred stock conversions	58,148,000		$ 1,000	58,147,000
Preferred stock conversions (in shares)			538,449
Issue of common stock upon exercise of stock options	115,000			115,000
Issue of common stock upon exercise of stock options (in shares)			936
Amortization of deferred stock-based compensation	217,000					217,000
Comprehensive loss:
Translation adjustment	(1,343,000)				(1,343,000)			(1,343,000)
Loss for the year	(14,977,000)						(14,977,000)	(14,977,000)
Comprehensive loss	(16,320,000)							(16,320,000)
Balance at Dec. 31, 2003	37,648,000		$ 1,000	109,603,000	(3,596,000)	(132,000)	(68,228,000)
Balance (in shares) at Dec. 31, 2003			886,219
Increase (Decrease) in Stockholders' Equity
Issue of common stock for cash on registered direct offering, net of expenses	8,541,000			8,541,000
Issue of common stock for cash on registered direct offering, net of expenses (in shares)			61,510
Warrant exercise (in shares)			3,233
Stock-based compensation	(1,918,000)			(2,050,000)		132,000
Comprehensive loss:
Translation adjustment	2,424,000				2,424,000			2,424,000
Loss for the year	(22,742,000)						(22,742,000)	(22,742,000)
Comprehensive loss	(20,318,000)							(20,318,000)
Balance at Dec. 31, 2004	23,953,000		$ 1,000	116,094,000	(1,172,000)		(90,970,000)
Balance (in shares) at Dec. 31, 2004			950,962
Comprehensive loss:
Translation adjustment	(1,786,000)				(1,786,000)			(1,786,000)
Loss for the year	(18,048,000)						(18,048,000)	(18,048,000)
Comprehensive loss	(19,834,000)							(19,834,000)
Balance at Dec. 31, 2005	4,119,000		$ 1,000	116,094,000	(2,958,000)		(109,018,000)
Balance (in shares) at Dec. 31, 2005			950,962
Increase (Decrease) in Stockholders' Equity
Issue of common stock to certain directors and officers upon exercise of stock options, stock-based awards exercised,restricted stock units and restricted stock (in shares)			92,630
Issue of shares on conversion of bridging loan and Loan Note Instrument (in shares)			65,187
Reverse Acquisition	16,255,000	$ 2,000		16,253,000
Reverse Acquisition (in shares)		2,046,813	281,133
Loan from Cyclacel Group plc waived	10,420,000			10,420,000
Issue of common stock and warrants for cash	42,362,000		$ 1,000	42,361,000
Issue of common stock and warrants for cash (in shares)			918,367
Stock-based compensation	9,600,000			9,600,000
Change in unrealized loss on investment	5,000				5,000
Comprehensive loss:
Translation adjustment	416,000				416,000			416,000
Loss for the year	(29,258,000)						(29,258,000)	(29,258,000)
Comprehensive loss	(28,842,000)							(28,842,000)
Balance at Dec. 31, 2006	53,919,000	$ 2,000	$ 2,000	194,728,000	(2,537,000)		(138,276,000)
Balance (in shares) at Dec. 31, 2006		2,046,813	2,308,279
Increase (Decrease) in Stockholders' Equity
Issue of common stock for cash on registered direct offering, net of expenses	33,357,000		$ 1,000	33,356,000
Issue of common stock for cash on registered direct offering, net of expenses (in shares)			607,095
Issue of warrants in connection with registered direct offering	(6,750,000)			(6,750,000)
Issue of common stock upon exercise of stock options	163,000			163,000
Issue of common stock upon exercise of stock options (in shares)			3,644
Stock-based compensation	1,733,000			1,733,000
Preferred stock dividends declared	(307,000)			(307,000)
Comprehensive loss:
Translation adjustment	(93,000)				(93,000)			(93,000)
Loss for the year	(24,053,000)						(24,053,000)	(24,053,000)
Comprehensive loss	(24,146,000)							(24,146,000)
Balance at Dec. 31, 2007	57,969,000	$ 2,000	$ 3,000	222,923,000	(2,630,000)		(162,329,000)
Balance (in shares) at Dec. 31, 2007		2,046,813	2,919,018
Increase (Decrease) in Stockholders' Equity
Stock-based compensation	1,698,000			1,698,000
Preferred stock dividends declared	(1,227,000)			(1,227,000)
Comprehensive loss:
Unrealized foreign exchange on intercompany loans	(12,330,000)				(12,330,000)			(12,330,000)
Translation adjustment	14,918,000				14,918,000			14,918,000
Loss for the year	(40,386,000)						(40,386,000)	(40,386,000)
Comprehensive loss	(37,798,000)							(37,798,000)
Balance at Dec. 31, 2008	20,642,000	$ 2,000	$ 3,000	223,394,000	(42,000)		(202,715,000)
Balance (in shares) at Dec. 31, 2008		2,046,813	2,919,018
Increase (Decrease) in Stockholders' Equity
Warrant re-pricing	44,000			44,000
Issue of common stock for cash on registered direct offering, net of expenses	2,847,000		$ 1,000	2,846,000
Issue of common stock for cash on registered direct offering, net of expenses (in shares)			571,429
Issue of common stock upon draw down of Committed Equity Finance Facility	1,030,000			1,030,000
Issue of common stock upon draw down of Committed Equity Finance Facility (in shares)			179,289
Issue of common stock to certain directors and officers upon exercise of stock options, stock-based awards exercised,restricted stock units and restricted stock	7,000			7,000
Issue of common stock to certain directors and officers upon exercise of stock options, stock-based awards exercised,restricted stock units and restricted stock (in shares)			7,887
Stock-based compensation	810,000			810,000
Comprehensive loss:
Unrealized foreign exchange on intercompany loans	5,651,000				5,651,000			5,651,000
Translation adjustment	(5,589,000)				(5,589,000)			(5,589,000)
Loss for the year	(19,570,000)						(19,570,000)	(19,570,000)
Comprehensive loss	(19,508,000)							(19,508,000)
Balance at Dec. 31, 2009	5,872,000	$ 2,000	$ 4,000	228,131,000	20,000		(222,285,000)
Balance (in shares) at Dec. 31, 2009		2,046,813	3,677,623
Increase (Decrease) in Stockholders' Equity
Issue of common stock for cash on registered direct offering, net of expenses	11,897,000		$ 1,000	11,896,000
Issue of common stock for cash on registered direct offering, net of expenses (in shares)			742,857
Issue of common stock upon draw down of Committed Equity Finance Facility	4,863,000			4,863,000
Issue of common stock upon draw down of Committed Equity Finance Facility (in shares)			402,704
Warrant exercise	2,499,000			2,499,000
Warrant exercise (in shares)			374,038
Issue of common stock on private placement, net of expenses	13,980,000		$ 1,000	13,979,000
Issue of common stock on private placement, net of expenses (in shares)			1,189,028
Issue of common stock to certain directors and officers upon exercise of stock options, stock-based awards exercised,restricted stock units and restricted stock	77,000			77,000
Issue of common stock to certain directors and officers upon exercise of stock options, stock-based awards exercised,restricted stock units and restricted stock (in shares)			29,367
Preferred stock conversions		$ (1,000)		3,516,000			(3,515,000)
Preferred stock conversions (in shares)		(833,671)	236,514
Stock-based compensation	1,746,000			1,746,000
Comprehensive loss:
Unrealized foreign exchange on intercompany loans	2,073,000				(2,073,000)			(2,073,000)
Translation adjustment	(2,084,000)				2,084,000			2,084,000
Loss for the year	(16,021,000)						(16,021,000)	(16,021,000)
Comprehensive loss	(16,010,000)							(16,010,000)
Balance at Dec. 31, 2010	24,924,000	$ 1,000	$ 7,000	266,706,000	31,000		(241,821,000)
Balance (in shares) at Dec. 31, 2010		1,213,142	6,652,131
Increase (Decrease) in Stockholders' Equity
Issue of common stock for cash on registered direct offering, net of expenses	9,272,000		$ 1,000	9,271,000
Issue of common stock for cash on registered direct offering, net of expenses (in shares)			1,088,235
Issue of common stock to certain directors and officers upon exercise of stock options, stock-based awards exercised,restricted stock units and restricted stock	3,000			3,000
Issue of common stock to certain directors and officers upon exercise of stock options, stock-based awards exercised,restricted stock units and restricted stock (in shares)			5,414
Issue of common stock upon exercise of stock options	$ 3,000
Issue of common stock upon exercise of stock options (in shares)	948
Stock-based compensation	$ 882,000			882,000
Preferred stock dividends declared	(364,000)			(364,000)
Comprehensive loss:
Unrealized foreign exchange on intercompany loans	(622,000)				(622,000)			(622,000)
Translation adjustment	648,000				648,000			648,000
Loss for the year	(15,243,000)						(15,243,000)	(15,243,000)
Comprehensive loss	(15,217,000)							(15,217,000)
Balance at Dec. 31, 2011	19,500,000	$ 1,000	$ 8,000	276,498,000	57,000		(257,064,000)
Balance (in shares) at Dec. 31, 2011		1,213,142	7,745,780
Increase (Decrease) in Stockholders' Equity
Issue of common stock on private placement, net of expenses	1,822,000		$ 1,000	1,821,000
Issue of common stock on private placement, net of expenses (in shares)			669,726
Issue of common stock on share purchase agreement	1,418,000			1,418,000
Issue of common stock on share purchase agreement (in shares)			233,530
Issue of common stock to certain directors and officers upon exercise of stock options, stock-based awards exercised,restricted stock units and restricted stock	94,000			94,000
Issue of common stock to certain directors and officers upon exercise of stock options, stock-based awards exercised,restricted stock units and restricted stock (in shares)			37,448
Issue of common stock upon exercise of stock options	$ 100,000
Issue of common stock upon exercise of stock options (in shares)	33,351
Stock-based compensation	$ 380,000			380,000
Comprehensive loss:
Unrealized foreign exchange on intercompany loans	4,550,000				4,550,000			4,550,000
Translation adjustment	(4,559,000)				(4,559,000)			(4,559,000)
Loss for the year	(13,186,000)						(13,186,000)	(13,186,000)
Comprehensive loss	(13,195,000)							$ (13,195,000)
Balance at Dec. 31, 2012	$ 10,019,000	$ 1,000	$ 9,000	$ 280,211,000	$ 48,000	$ 0	$ (270,250,000)
Balance (in shares) at Dec. 31, 2012		1,213,142	8,686,484

CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	12 Months Ended			197 Months Ended
	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2012
Operating activities:
Net loss	$ (13,186)	$ (15,243)	$ (16,021)	$ (266,735)
Adjustments to reconcile net loss to net cash used in operating activities:
Accretion of interest on notes payable, net of amortization of debt premium				100
Amortization of investment premiums, net				(2,297)
Change in valuation of derivative	23	20		351
Change in valuation of warrants	(51)	(629)	338	(6,706)
Non-cash consideration associated with stock purchase agreement	423			423
Depreciation	60	241	457	12,615
Amortization of intangible assets				886
Fixed asset impairment				221
Unrealized foreign exchange (gains) losses				7,747
Deferred revenue				(98)
Compensation for warrants issued to non-employees				1,215
Shares issued for IP rights				446
Loss (gain) on disposal of property, plant and equipment	(62)	1	(13)	38
Goodwill and intangibles impairment				7,934
Stock-based compensation	380	882	1,746	19,403
Provision for restructuring				1,779
Amortization of issuance costs of Preferred Ordinary 'C' shares				2,517
Transaction costs on sale of Economic Rights	33			33
Gain on termination of distribution agreements	(1,192)			(1,192)
Changes in operating assets and liabilities:
Prepaid expenses and other assets	(239)	174	516	(297)
Accounts payable and other current liabilities	1,768	577	(3,067)	(3,545)
Net cash used in operating activities	(12,043)	(13,977)	(16,044)	(225,162)
Investing activities:
Purchase of ALIGN				(3,763)
Purchase of property, plant and equipment	(12)	(6)	(8)	(8,849)
Proceeds from sale of property, plant and equipment	62	5	41	225
Purchase of short-term investments on deposit, net of maturities				(156,657)
Cash proceeds from redemption of short term securities				162,729
Net cash provided by (used in) investing activities	50	(1)	33	(6,315)
Financing activities:
Payments of capital lease obligations				(3,719)
Proceeds from issuance of ordinary and preferred ordinary shares, net of issuance costs			30,820	121,678
Proceeds from issuance of common stock and warrants, net of issuance costs	3,881	9,267	2,576	95,552
Proceeds from the exercise of stock options and warrants, net of issuance costs	94	3		267
Payment of preferred stock dividend		(364)		(1,898)
Repayment of government loan				(455)
Government loan received				414
Loan received from Cyclacel Group plc				9,103
Proceeds of committable loan notes issued from shareholders				8,883
Loans received from shareholders				1,645
Cash and cash equivalents assumed on stock purchase of Xcyte				17,915
Costs associated with stock purchase				(1,951)
Net cash provided by financing activities	3,975	8,906	33,396	247,434
Effect of exchange rate changes on cash and cash equivalents	(19)	26	617	455
Net increase (decrease) in cash and cash equivalents	(8,037)	(5,046)	18,002	16,412
Cash and cash equivalents, beginning of period	24,449	29,495	11,493
Cash and cash equivalents, end of period	16,412	24,449	29,495	16,412
Cash received during the period for:
Interest	10	31	11	11,756
Taxes	$ 565	$ 685	1,082	18,772
Cash paid during the period for:
Interest			$ (155)	(1,914)
Schedule of non-cash transactions:
Acquisitions of equipment purchased through capital leases				3,470
Issuance of common shares in connection with license agreements				592
Issuance of Ordinary shares on conversion of bridging loan				1,638
Issuance of Preferred Ordinary 'C' shares on conversion of secured convertible loan notes and accrued interest				8,893
Issuance of Ordinary shares in lieu of cash bonus				164
Issuance of other long term payable on ALIGN acquisition				$ 1,122

Organization of the Company	12 Months Ended
Organization of the Company	Dec. 31, 2012
Organization of the Company
Organization of the Company	1 Organization of the Company Cyclacel Pharmaceuticals, Inc. (Cyclacel or the Company) is a development-stage biopharmaceutical company dedicated to the development and commercialization of novel, mechanism-targeted drugs to treat human cancers and other serious diseases. Cyclacel’s strategy is to build a diversified biopharmaceutical business focused in hematology and oncology based on a portfolio of commercial products and a development pipeline of novel drug candidates. Cyclacel’s clinical development priorities are focused on sapacitabine in the following indications: · Acute myeloid leukemia, or AML in the elderly; · Myelodysplastic syndromes, or MDS; and · Non-small cell lung cancer or NSCLC. On January 11, 2011, the Company opened enrollment of the SEAMLESS pivotal Phase 3 trial for the Company’s sapacitabine oral capsules as a front-line treatment of elderly patients aged 70 years or older with newly diagnosed AML who are not candidates for intensive induction chemotherapy under a Special Protocol Assessment, or SPA, reached with the U.S. Food & Drug Administration, or FDA. The Company has ongoing clinical programs in development awaiting further data. Once data becomes available and is reviewed, the Company will determine the feasibility of pursuing further development and/or partnering these assets, including sapacitabine in combination with seliciclib and seliciclib in NSCLC and nasopharyngeal cancer, or NPC. In addition, we marketed directly in the United States Xclair® Cream for radiation dermatitis and Numoisyn® Liquid and Numoisyn® Lozenges for xerostomia. However, the distribution agreements for the promotion and sale of these products were terminated effective September 30, 2012. As a development stage enterprise, substantially all efforts of the Company to date have been devoted to performing research and development, conducting clinical trials, developing and acquiring intellectual property, raising capital and recruiting and training personnel. *Capital Resources* The Company’s existing capital is not sufficient to complete the development and commercialization of any of its product candidates. *Basis of Presentation* The accompanying consolidated financial statements as of December 31, 2011and 2012, and for each of the three years in the period ended December 31, 2012 and for the period from August 13, 1996 (inception) to December 31, 2012, have been prepared in accordance with accounting principles generally accepted in the United States, or U.S. GAAP. The consolidated financial statements include the financial statements of Cyclacel Pharmaceuticals, Inc. and all of the Company’s wholly owned subsidiaries. All intercompany balances and transactions have been eliminated. *Developments* Stock Purchase Agreement On December 14, 2012, the Company entered into a common stock purchase agreement (“the Purchase Agreement”) with Aspire Capital Fund, LLC (“Aspire”). Upon execution of the Purchase Agreement, Aspire purchased 158,982 shares of common stock for an aggregate purchase price of $1.0 million based the closing price of the Company’s common stock December 13, 2012, the date upon which the business terms were agreed. Under the terms of the Purchase Agreement, Aspire committed to purchase up to an additional 1,455,787 shares from time to time as directed by the Company over the next two years at prices derived from the market prices on or near the date of each sale. However, such commitment is limited to an additional $19.0 million of share purchases. In consideration for entering into the Purchase Agreement, concurrent with the execution of the Purchase Agreement, the Company issued 74,548 shares of its common stock to Aspire for no consideration. Grant Award In November 2012, the Company was awarded a grant of approximately $1.9 million from the UK Government’s Biomedical Catalyst to complete an Investigational New Drug (“IND”) directed preclinical development of CYC065, a novel orally available, second generation, CDK inhibitor. Reverse Stock Split On August 24, 2012, the Company effected a 1-for-7 reverse stock split of its shares of common stock in order to increase the per share trading price of the Company’s shares of common stock to satisfy the $1.00 minimum bid price requirement for continued listing on the NASDAQ Global Market. The Company received notification from NASDAQ that as of September 11, 2012, the Company evidenced a closing bid price of its common stock price in excess of the $1.00 minimum requirement for at least 10 consecutive trading days. Accordingly, the Company has regained compliance with Listing Rule 5450(a)(1). All share and per share information presented gives effect to the reverse stock split. Termination and Settlement Agreement On August 10, 2012, the Company entered into an agreement with Sinclair to terminate, effective September 30, 2012, the distribution agreements relating to the promotion and sale of Xclair®, Numoisyn® Lozenges and Numoisyn® Liquid. The termination agreement includes a minimum royalty arrangement based on future net revenues, under which Sinclair will pay the Company a minimum of approximately $1.0 million in quarterly installments over the three years ending on September 30, 2015. The operating results associated with the promotion and sale of Xclair®, Numoisyn® Liquid and Numoisyn® Lozenges are classified within (loss) income from discontinued operations, net of tax in the consolidated statements of operations for all periods presented, and the associated assets and liabilities are classified within current assets of discontinued operations, long term assets of discontinued operations and current liabilities of discontinued operations, as appropriate, in the condensed consolidated balance sheets for all applicable periods presented. See Note 3 — Discontinued Operations for further details. Recent Accounting Pronouncement On January 1, 2012, the Company adopted new guidance issued by the Financial Accounting Standards Board (“FASB”) regarding the presentation of comprehensive income. This guidance requires that all non-owner changes in stockholders’ equity be presented either in a single continuous statement of comprehensive income or in two separate but consecutive statements and requires retrospective application of this standard. The Company has elected to present the components of comprehensive income in two separate but consecutive statements. On January 1, 2012, the Company adopted new guidance issued by the FASB relating to amendments to disclosures about fair value measurements. The amendments change the wording used to describe the requirements for measuring fair value, changes certain fair value measurement principles and enhances disclosure requirements.

- Definition

The entire disclosure for organization, consolidation and basis of presentation of financial statements disclosure.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 275
-SubTopic 10
-URI http://asc.fasb.org/subtopic&trid=2134480

Reference 2: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
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-URI http://asc.fasb.org/subtopic&trid=2209116

Reference 3: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
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Reference 4: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
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-URI http://asc.fasb.org/subtopic&trid=2197480

Reference 5: http://www.xbrl.org/2003/role/presentationRef
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Reference 6: http://www.xbrl.org/2003/role/presentationRef
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Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
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Reference 8: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
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Reference 9: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
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-Name Accounting Standards Codification
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-Name Accounting Standards Codification
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-URI http://asc.fasb.org/extlink&oid=6359566&loc=d3e326-107755

Reference 13: http://www.xbrl.org/2003/role/presentationRef
-Publisher AICPA
-Name Statement of Position (SOP)
-Number 94-6
-Paragraph 10
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 14: http://www.xbrl.org/2003/role/presentationRef
-Publisher AICPA
-Name Accounting Research Bulletin (ARB)
-Number 51
-Paragraph 2-6
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 15: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name FASB Interpretation (FIN)
-Number 46R
-Paragraph 4, 14, 15
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 16: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name FASB Staff Position (FSP)
-Number FAS140-4/FIN46(R)-8
-Paragraph 8, C1, C7
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

+ Details

Summary of Significant Accounting Policies

12 Months Ended

Dec. 31, 2012

Summary of Significant Accounting Policies

Summary of Significant Accounting Policies

2 Summary of Significant Accounting Policies

Use of Estimates

The preparation of financial statements in accordance with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities and related disclosures of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Critical estimates include product returns reserve percentages and inputs used to determine stock-based compensation expense and the fair value of financial instruments, such as the Economic Rights and other liabilities measured at fair value. Cyclacel reviews its estimates on an ongoing basis. The estimates are based on historical experience and on various other assumptions that the Company believes to be reasonable under the circumstances. Actual results may differ from these estimates. Cyclacel believes the judgments and estimates required by the following accounting policies to be significant in the preparation of the Company’s consolidated financial statements.

Risks and Uncertainties

Drug candidates developed by the Company typically will require approvals or clearances from the FDA or other international regulatory agencies prior to commercialize sales. There can be no assurance that the Company’s drug candidates will receive any of the required approvals or clearances. If the Company was denied approval or clearance or such approval was delayed, or is unable to obtain the necessary financing to complete development and approval, it may have a material adverse impact on the Company.

Foreign currency and currency translation

Transactions that are denominated in a foreign currency are remeasured into the functional currency at the current exchange rate on the date of the transaction. Any foreign currency-denominated monetary assets and liabilities are subsequently remeasured at current exchange rates, with gains or losses recognized as foreign exchange (losses)/gains in the statement of operations.

The assets and liabilities of the Company’s international subsidiary are translated from its functional currency into United States dollars at exchange rates prevailing at the balance sheet date. Average rates of exchange during the period are used to translate the statement of operations, while historical rates of exchange are used to translate any equity transactions.

Translation adjustments arising on consolidation due to differences between average rates and balance sheet rates, as well as unrealized foreign exchange gains or losses arising from translation of intercompany loans that are of a long-term-investment nature, are recorded in other comprehensive income.

Segments

After considering its business activities and geographic reach, the Company has concluded that it operates in just one operating segment being the discovery, development and commercialization of novel, mechanism-targeted drugs to treat cancer and other serious disorders, with development operations in two geographic areas, namely the United States and the United Kingdom.

Cash and Cash Equivalents

Cash equivalents are stated at cost, which is substantially the same as fair value. The Company considers all highly liquid investments with an original maturity of three months or less at the time of initial purchase to be cash equivalents and categorizes such investments as held to maturity. The objectives of the Company’s cash management policy are to safeguard and preserve funds, to maintain liquidity sufficient to meet Cyclacel’s cash flow requirements and to attain a market rate of return.

Inventory

Cyclacel values inventories at the lower of cost or market value. The Company determines cost using the first-in, first-out method. As of December 31, 2011, all inventories were classified as finished goods and are included in current assets of discontinued operations. The Company did not have any inventory as of December 31, 2012.

Fair Value of Financial Instruments

Financial instruments consist of cash and cash equivalents, accounts payable, accrued liabilities, common stock warrants, financial instruments associated with stock purchase agreements, and other arrangements. The carrying amounts of cash and cash equivalents, accounts payable, and accrued liabilities approximate their respective fair values due to the nature of the accounts, notably their short maturities. Economic Rights, warrants, financial instruments associated with stock purchase agreements, and certain other liabilities are measured at fair value using applicable inputs as described in Note 6, Fair Value.

Property, Plant and Equipment

Property, plant and equipment is stated at cost and depreciated on a straight-line basis over the estimated useful lives of the related assets, which are generally three to five years. Amortization of leasehold improvements is computed using the straight-line method over the shorter of the remaining lease term or the estimated useful life of the related assets, currently between five and fifteen years. Upon sale or retirement of assets, the costs and related accumulated depreciation and amortization are removed from the balance sheet and the resulting gain or loss on sale is reflected as a component of operating income or loss. Expenditures for maintenance and repairs are charged to operating expenses as incurred.

During years ended December 31, 2010 and 2011, the Company sold fixed assets totaling approximately $28,000 and $6,000, respectively. During the year ended December 31, 2012, the Company sold fully depreciated assets for proceeds of approximately $62,000.

Impairment of Long-lived Assets

The Company reviews property, plant and equipment for impairment whenever events or changes in business circumstances indicate that the carrying amount of the assets may not be fully recoverable. The Company assesses the recoverability of the potentially affected long-lived assets by determining whether the carrying value of such assets can be recovered through undiscounted future operating cash flows.

Impairment, if any, is measured as the amount by which the carrying amount of a long-lived asset (or asset group) exceeds its fair value.

Measurement of fair value is determined using the income-based valuation methodology. The income —based valuation approach measures the fair value of an asset (or asset group) by calculating the present value of the future expected cash flows to be derived from that asset, from the perspective of a market participant. Such cash flows are discounted using a rate of return that incorporates the risk-free rate for the use of funds, the expected rate of inflation and risks associated with using the asset. If the carrying amount of a long-lived asset exceeds its fair value, an impairment loss is recognized.

Revenue Recognition

Product sales

Revenue from product sales relate to operations that have been discontinued. Accordingly, such revenue has been reported as a component of loss from discontinued operations, net of tax on the consolidated statements of operations. The Company recognizes revenue from product sales when persuasive evidence of an arrangement exists; delivery has occurred or services have been rendered; the selling price is fixed or determinable; and collectability is reasonably assured.

The Company offered right of return on these product sales, and has considered the guidance in ASC 605-15, “Revenue Recognition -Products” (“ASC 605-15”) and ASC 605 — 10 “Revenue Recognition - Overall” (“ASC 605-10”). Under these guidelines, the Company accounts for all product sales using the “sell-through” method. Under the sell-through method, revenue is not recognized upon shipment of product to distributors. Instead, the Company records deferred revenue at gross invoice sales price less 5% of the current wholesale acquisition price in accordance with its returns policy and deferred cost of sales at the cost at which those goods were held in inventory. The Company recognizes revenue when such inventory is sold through to pharmacies. To estimate product sold through to pharmacies, the Company relies on third-party information, including information obtained from significant distributors with respect to their inventory levels and sell-through to pharmacies. The Company also estimates its provision for returned products based on historical returns for each product and this provision is charged against revenues and reported in loss from discontinued operations.

Collaboration, research and development, and grant revenue

Certain of the Company’s revenues are earned from collaborative agreements. The Company recognizes revenue when persuasive evidence of an arrangement exists; delivery has occurred or services have been rendered; the fee is fixed or determinable; and collectability is reasonably assured. Determination of whether these criteria have been met is based on management’s judgments regarding the nature of the research performed, the substance of the milestones met relative to those the Company must still perform, and the collectability of any related fees. Should changes in conditions cause management to determine these criteria are not met for certain future transactions, revenue recognized for any reporting period could be adversely affected.

Research and development revenues, which are earned under agreements with third parties for contract research and development activities, are recorded as the related services are performed. Milestone payments are non-refundable and recognized as revenue when earned, as evidenced by achievement of the specified milestones and the absence of ongoing performance obligations. Any amounts received in advance of performance are recorded as deferred revenue. None of the revenues recognized to date are refundable if the relevant research effort is not successful.

Grant revenues from government agencies and private research foundations are recognized as the related qualified research and development costs are incurred, up to the limit of the prior approval funding amounts. Grant revenues are not refundable.

Clinical Trial Accounting

Data management and monitoring of the Company’s clinical trials are performed with the assistance of contract research organizations (‘‘CROs’’) or clinical research associates (‘‘CRAs’’) in accordance with the Company’s standard operating procedures. Typically, CROs and some CRAs bill monthly for services performed, and others bill based upon milestones achieved. For outstanding amounts, the Company accrues unbilled clinical trial expenses based on estimates of the level of services performed each period. Costs of setting up clinical trial sites for participation in the trials are expensed immediately as research and development expenses. Clinical trial costs related to patient enrollment are accrued as patients are entered into and progress through the trial. Any initial payment made to the clinical trial site is recognized upon execution of the clinical trial agreements and expensed as research and development expenses.

Research and Development Expenditures

Research and development expenses consist primarily of costs associated with the Company’s product candidates, upfront fees, milestones, compensation and other expenses for research and development personnel, supplies and development materials, costs for consultants and related contract research, facility costs and depreciation. Expenditures relating to research and development are expensed as incurred.

Patent Costs

Patent prosecution costs are charged to operations as incurred as recoverability of such expenditure is uncertain.

Leased Assets

The costs of operating leases are charged to operations on a straight-line basis over the lease term.

The Company treats a lease as a capital lease when the Company enters into a lease which entails taking substantially all the risks and rewards of ownership of an asset. The asset is recorded in the balance sheet and is depreciated in accordance with the aforementioned depreciation policies. The capital elements of future lease payments are recorded as liabilities and the interest is charged to operations over the period of the lease.

Income Taxes

The Company accounts for income taxes under the liability method. Under this method, deferred tax assets and liabilities are determined based on the difference between the financial statement and tax bases of assets and liabilities using enacted tax rates in effect for the year in which the differences are expected to affect taxable income. Valuation allowances are established when necessary to reduce deferred tax assets to the amounts expected to be realized.

The Company applies the accounting guidance codified in ASC 740 “Income taxes” (“ASC 740”) related to accounting for uncertainty in income taxes. ASC 740 specifies the accounting the accounting for uncertainty in income taxes recognized in a company’s financial statements by prescribing a minimum probability threshold a tax position is required to meet before being recognized in the financial statements.

Credit is taken in the accounting period for research and development tax credits, which will be claimed from H. M. Revenue & Customs, the United Kingdom’s taxation and customs authority, in respect of qualifying research and development costs incurred in the same accounting period.

Net Loss Per Common Share

The Company calculates net loss per common share in accordance with ASC 260 “Earnings Per Share” (“ASC 260”). Basic and diluted net loss per common share was determined by dividing net loss applicable to common stockholders by the weighted average number of common shares outstanding during the period. The Company’s potentially dilutive shares, which include outstanding common stock options, restricted stock, restricted stock units, convertible preferred stock and common stock warrants, have not been included in the computation of diluted net loss per share for all periods as the result would be anti-dilutive.

	Year ended December 31, 2010	Year ended December 31, 2011	Year ended December 31, 2012
Stock options	498,562	502,249	463,023
Restricted Stock and Restricted Stock Units	8,555	38,089	39,377
Convertible preferred stock	73,747	73,747	73,747
Contingently issuable shares and common stock warrants associated with Economic Rights	—	—	440,375
Options issued in connection with the October 2010 financing	891,771	—	—
Common stock warrants	1,429,313	1,973,431	1,973,427
Total shares excluded from calculation	2,901,948	2,587,516	2,989,949

Fair Value Measurements

Inputs used to determine fair value of financial and non-financial assets and liabilities are categorized using a fair value hierarchy that prioritizes observable and unobservable inputs into three broad levels, from Level 1, for quoted prices (unadjusted) in active markets for identical assets or liabilities, to Level 3, for unobservable inputs (see “Note 6 — Fair Value”). Management reviews the categorization of fair value inputs on a periodic basis and may determine that it is necessary to transfer an input from one level of the fair value hierarchy to another based on changes in events or circumstances, such as a change in the observability of an input. Any such transfer will be recognized at the end of the reporting period.

Stock-based Compensation

The Company grants stock options, restricted stock units and restricted stock to officers, employees and directors under the Amended and Restated Equity Incentive Plan (“2006 Plan”), which was approved on March 16, 2006, as amended on May 21, 2007, and subsequently amended and restated on April 14, 2008. Under the 2006 Plan, the Company has granted various types of awards, which are described more fully in Note 11 - “Stock-Based Compensation Arrangements”. The Company accounts for these awards under ASC 718 “Compensation — Stock Compensation” (“ASC 718”).

ASC 718 requires measurement of compensation cost for all stock-based awards at fair value on date of grant and recognition of compensation over the requisite service period for awards expected to vest. The fair value of restricted stock and restricted stock units is determined based on the number of shares granted and the quoted price of the Company’s common stock on the date of grant. The determination of grant-date fair value for stock option awards is estimated using the Black-Scholes model, which includes variables such as the expected volatility of the Company’s share price, the anticipated exercise behavior of employees, interest rates, and dividend yields. These variables are projected based on historical data, experience, and other factors. Changes in any of these variables could result in material adjustments to the expense recognized for share-based payments. Such value is recognized as expense over the requisite service period, net of estimated forfeitures, using the straight-line attribution method. The estimation of stock awards that will ultimately vest requires judgment, and to the extent actual results or updated estimates differ from current estimates, such amounts are recorded as a cumulative adjustment in the period estimates are revised. The Company considers many factors when estimating expected forfeitures, including type of awards granted, employee class, and historical experience. Actual results and future estimates may differ substantially from current estimates.

Comprehensive Income (Loss)

In accordance with ASC 220, “Comprehensive Income” (“ASC 220”) all components of comprehensive income (loss), including net income (loss), are reported in the financial statements in the period in which they are recognized. Comprehensive income (loss) is defined as the change in equity during a period from transactions and other events and circumstances from non-owner sources. Net income (loss) and other comprehensive income (loss), including foreign currency translation adjustments, are reported, net of any related tax effect, to arrive at comprehensive income (loss). No taxes were recorded on items of other comprehensive income.

Recent Accounting Pronouncements

In March 2013, the Financial Accounting Standards Board (“FASB”) issued guidance relating to certain foreign currency matters. This guidance clarifies the parent company’s accounting for the cumulative translation adjustment when a reporting entity ceases to have a controlling financial interest in a subsidiary or group of assets that is a nonprofit activity or a business within a foreign entity or of an investment in a foreign entity. The guidance is effective prospectively for fiscal years (and interim reporting periods within those years) beginning after December 15, 2013. We do not expect the adoption of this guidance to have a material impact on our consolidated financial statements.

In February 2013, the FASB issued guidance relating to obligations resulting from joint and several liability arrangements for which the total amount of the obligation is fixed at the reporting date. This provides guidance for the recognition, measurement, and disclosure of obligations resulting from joint and several liability arrangements for which the total amount of the obligation is fixed at the reporting date, except for obligations addressed within existing guidance in U.S. GAAP. The guidance is effective for fiscal years, and interim periods within those years, beginning after December 15, 2013. The guidance should be applied retrospectively to all prior periods presented for those obligations resulting from joint and several liability arrangements that exist at the beginning of an entity’s fiscal year of adoption. We do not expect the adoption of this guidance to have a material impact on our consolidated financial statements.

In February 2013, the FASB issued guidance on the reporting of amounts reclassified out of accumulated other comprehensive income. The guidance requires entities to present (either on the face of the statement where net income is presented or in the notes) the effects on the line items of net income of significant amounts reclassified out of accumulated other comprehensive income, but only if the item reclassified is required under U.S. GAAP to be reclassified to net income in its entirety in the same reporting period. For other reclassification items (that are not required under U.S. GAAP) to be reclassified directly to net income in their entirety in the same reporting period, an entity should cross-reference to other disclosures currently required under U.S. GAAP. The guidance is effective for all reporting periods (interim and annual) beginning after December 15, 2012. We do not expect the adoption of this guidance to have a material impact on our consolidated financial statements.

In January 2013, the FASB issued guidance to clarify the scope of the previously issued guidance which required companies to disclose information about offsetting and related arrangements to enable users of financial statements to understand the effect of those arrangements on its financial position. This guidance clarifies that ordinary trade receivables and receivables are not within the scope of the guidance and that the guidance only applies to derivatives, repurchase agreements and reverse purchase agreements, and securities borrowing and securities lending transactions that are either offset in accordance with specific criteria or subject to a master netting arrangement or similar agreement. The guidance is effective for fiscal years beginning on or after January 1, 2013, and interim periods within those annual periods. An entity should provide the required disclosures retrospectively for all comparative periods presented. We do not expect the adoption of this guidance to have a material impact on our consolidated financial statements.

In July 2012, the FASB issued guidance on testing indefinite-lived intangible assets for impairment. This guidance states that an entity has the option first to assess qualitative factors to determine whether the existence of events and circumstances indicates that it is more likely than not that the indefinite-lived intangible asset is impaired. If, after assessing the totality of events and circumstances, an entity concludes that it is not more likely than not that the indefinite-lived intangible asset is impaired, then the entity is not required to take further action. However, if an entity concludes otherwise, then it is required to determine the fair value of the indefinite-lived intangible asset and perform the quantitative impairment test by comparing the fair value with the carrying. Under the guidance, an entity also has the option to bypass the qualitative assessment for any indefinite-lived intangible asset in any period and proceed directly to performing the quantitative impairment test. An entity will be able to resume performing the qualitative assessment in any subsequent period. The guidance is effective for annual and interim impairment tests performed for fiscal years beginning after September 15, 2012. Early adoption is permitted. We do not expect the adoption of this guidance to have a material impact on our consolidated financial statements.

Discontinued Operations

12 Months Ended

Dec. 31, 2012

Discontinued Operations

Discontinued Operations

3 Discontinued Operations

On August 10, 2012, the Company entered into an agreement with Sinclair to terminate, effective September 30, 2012, the distribution agreements relating to the promotion and sale of Xclair®, Numoisyn® Lozenges and Numoisyn® Liquid.

Product revenue, cost of goods sold and selling, general and administrative costs related to the promotion and sales of the of Xclair®, Numoisyn® Liquid and Numoisyn® Lozenges have been reclassified from operating results from continuing operations to (loss) income from discontinued operations in the consolidated statement of operations for all periods presented as follows:

	Year ended December 31, 2010			Year ended December 31, 2011			Year ended December 31, 2012			Period from August 13, 1996 (inception) to December 31, 2012
Product revenue	$	574		$	699		$	583		$	3,604
Cost of goods sold	(418		)	(360		)	(293		)	(2,045		)
Selling, general and administrative	(1,287		)	(979		)	(607		)	(9,295		)
Goodwill and intangible impairment	—			—			—			(5,187		)
Interest income	—			—			32			32
Interest expense	—			—			—			(110		)
Gain on termination of license agreement	—			—			1,192			1,192
(Loss) income from discontinued operations	(1,131		)	(640		)	907			(11,809		)
Income tax expense	—			—			(337		)	(337		)
(Loss) income from discontinued operations, net of tax	$	(1,131	)	$	(640	)	$	570		$	(12,146	)

The approximately $0.9 million present value of the estimated $1.0 million of minimum royalty payments the Company will receive over three years ending September 30, 2015 arising from the termination and settlement agreement and the recognition of approximately $0.3 million associated with a $0.3 million product returns provision liability for which an offsetting asset has been recorded based on our rights under the termination and settlement agreement resulted in a $1.2 million gain on termination of the distribution agreements for the year ended December 31, 2012.

The assets and liabilities associated with product promotion and sale have been classified within assets and liabilities of discontinued operations in the accompanying consolidated balance sheets:

	December 31, 2011		December 31, 2012

Current assets of discontinued operations:
Inventory	$	182	$	—
Short term portion of minimum royalty arrangement receivable, net	—		536
Returns indemnification receivable	—		325
Accounts receivable and other current assets	131		—
Total current assets of discontinued operations	313		861
Long-term assets of discontinued operations:
Long-term portion of minimum royalty arrangement receivable, net	—		353
Total assets of discontinued operations	313		1,214

Current liabilities of discontinued operations:
Accounts payable	$	46	$	10
Returns provision	202		325
Accrued liabilities and other current liabilities	279		—
Total current liabilities of discontinued operations	$	527	$	335

- Definition

The entire disclosure for the facts and circumstances leading to the completed or expected disposal, manner and timing of disposal, the gain (loss) recognized in the income statement and the income statement caption that includes that gain (loss), amounts of revenues and pretax profit or loss reported in discontinued operations, the segment in which the disposal group was reported, and the classification (whether sold or classified as held for sale) and carrying value of the assets and liabilities comprising the disposal group. Includes all disposal groups, including those classified as components of the entity (discontinued operations).

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
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-Section 50
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=6360339&loc=d3e1361-107760

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Reference 10: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 144
-Paragraph 43-48
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

+ Details

Significant Contracts	12 Months Ended
Significant Contracts	Dec. 31, 2012
Significant Contracts
Significant Contracts	4 Significant Contracts *Distribution, Licensing and Research Agreements* The Company has entered into licensing agreements with academic and research organizations. Under the terms of these agreements, the Company has received licenses to technology and patent applications. The Company is required to pay royalties on future sales of product employing the technology or falling under claims of patent applications. Pursuant to the Daiichi Sankyo license under which the Company licenses certain patent rights for sapacitabine, its lead drug candidate, the Company is under an obligation to use reasonable endeavors to develop a product and obtain regulatory approval to sell a product and has agreed to pay Daiichi Sankyo an up-front fee, reimbursement for Daiichi Sankyo’s enumerated expenses, milestone payments and royalties on a country-by-country basis. The up-front fee and certain past reimbursements have been paid and, as a result of the SEAMLESS trial entering Phase 3 during the first quarter of 2011, a milestone payment of $1.6 million was paid in April 2011. A further $10.0 million in aggregate milestone payments could be payable subject to achievement of all the specific contractual milestones and the Company’s decision to continue with these projects. Royalties are payable in each country for the term of patent protection in the country or for ten years following the first commercial sale of licensed products in the country, whichever is later. Royalties are payable on net sales. Net sales are defined as the gross amount invoiced by the Company or its affiliates or licensees, less discounts, credits, taxes, shipping and bad debt losses. The agreement extends from its commencement date to the date on which no further amounts are owed under it. If the Company wishes to appoint a third party to develop or commercialize a sapacitabine-based product in Japan, within certain limitations, Daiichi Sankyo must be notified and given a right of first refusal to develop and/or commercialize in Japan. In general, the license may be terminated by the Company for technical, scientific, efficacy, safety, or commercial reasons on six months notice, or twelve months, if after a launch of a sapacitabine-based product, or by either party for material default. Effective July 11, 2011, the license agreement was amended to irrevocably waive a termination right Daiichi Sankyo possessed under a provision of the agreement that required the Company to obtain regulatory approval to sell sapacitabine in at least one country by September 2011, and releases the Company from all claims and liability of any kind arising under such provision. The amendment further provides that the royalty due from the Company to Daiichi Sankyo on future net sales of sapacitabine be increased by a percentage between 1.25% and 1.50% depending on the level of net sales of sapacitabine realized. In connection with the asset acquisition of ALIGN on October 5, 2007, the Company acquired distribution rights for the exclusive rights to sell and distribute three products in the United States. As described in Note 3, each of the agreements covering the three products was terminated as of September 30, 2012. The Company, as part of securing long term supply arrangements, had commitments to make payments totaling $1.3 million, $0.6 million of which was paid in 2009 and the remainder of $0.7 million was paid in 2010. Also, the Company had a minimum purchase obligation equivalent to the value of product purchased in the previous year. For the year ended December 31, 2011 this equated to $0.2 million.

Cash and Cash Equivalents

12 Months Ended

Dec. 31, 2012

Cash and Cash Equivalents

Cash and Cash Equivalents

5 Cash and Cash Equivalents

The following is a summary of cash and cash equivalents at December 31, 2011 and 2012:

	December 31,
	2011	2012
	$000	$000
Cash	4,555	4,090
Investments with original maturity of less than three months at the time of purchase	19,894	12,322
Total cash and cash equivalents	24,449	16,412

Investments with original maturity of less than three months at time of purchase is made up of money market funds and commercial paper.

- Definition

The entire disclosure for cash and cash equivalent footnotes, which may include the types of deposits and money market instruments, applicable carrying amounts, restricted amounts and compensating balance arrangements. Cash and equivalents include: (1) currency on hand (2) demand deposits with banks or financial institutions (3) other kinds of accounts that have the general characteristics of demand deposits (4) short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates. Generally, only investments maturing within three months from the date of acquisition qualify.

+ References

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-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
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-Number Topic 6
-Section H
-Subsection 3

Reference 8: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Regulation S-X (SX)
-Number 210
-Section 02
-Paragraph 1
-Article 5

Reference 9: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 95
-Paragraph 8, 9, 10
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

+ Details

Fair Value

12 Months Ended

Dec. 31, 2012

Fair Value

Fair Value

6 Fair Value

Fair value measurements

As defined in ASC 820, Fair Value Measurements and Disclosures (“ASC 820”), fair value is based on the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. In order to increase consistency and comparability in fair value measurements, ASC 820 establishes a fair value hierarchy that prioritizes observable and unobservable inputs used to measure fair value into three broad levels, which are described below:

· Level 1: Quoted prices (unadjusted) in active markets that are accessible at the measurement date for assets or liabilities. The fair value hierarchy gives the highest priority to Level 1 inputs.

· Level 2: Inputs other than quoted prices within Level 1 that are observable for the asset or liability, either directly or indirectly.

· Level 3: Unobservable inputs that are used when little or no market data is available. The fair value hierarchy gives the lowest priority to Level 3 inputs.

In determining fair value, the Company utilizes valuation techniques that maximize the use of observable inputs and minimize the use of unobservable inputs to the extent possible as well as considering counterparty credit risk in its measurement of fair value.

The fair value of the Company’s financial assets and liabilities that are measured on a recurring basis were determined using the following inputs as of December 31, 2011:

	Level 1	Level 2	Level 3	Total
	$000	$000	$000	$000
ASSETS
Cash equivalents	19,894	—	—	19,894
Total assets	19,894	—	—	19,894

LIABILITIES
Other liabilities measured at fair value:
Warrants liability	—	—	51	51
Scottish Enterprise agreement	—	—	20	20
Other liabilities measured at fair value	—	—	71	71
Total liabilities	—	—	71	71

The fair value of the Company’s financial assets and liabilities that are measured on a recurring basis were determined using the following inputs as of December 31, 2012:

	Level 1	Level 2	Level 3	Total
	$000	$000	$000	$000
ASSETS
Cash equivalents	5,523	6,799	—	12,322
Financial instrument associated with stock purchase agreement	—	—	—	—
Total assets	5,523	6,799	—	12,322

LIABILITIES
Economic rights	—	—	1,120	1,120
Other liabilities measured at fair value:
Warrants liability	—	—	—	—
Scottish Enterprise agreement	—	—	20	20
Other liabilities measured at fair value	—	—	20	20
Total liabilities	—	—	1,140	1,140

The following table reconciles the beginning and ending balances of Level 3 inputs for the year ended December 31, 2012:

	Level 3
	$000
Balance as of December 31, 2011	71
Sale of Economic Rights	1,097
Change in valuation of Economic Rights	23
Change in valuation of warrants liability	(51	)
Balance as of December 31, 2012	1,140

Financial Instrument Associated with Stock Purchase Agreement

On December 14, 2012, the Company entered into a common stock purchase agreement with Aspire under which Aspire purchased 158,982 shares of common stock for an aggregate purchase price of $1.0 million and committed to purchase up to an additional 1,455,787 shares from time to time as directed by the Company over the next two years at prices derived from the market prices on or near the date of each sale. However, such commitment is limited to an additional $19.0 million of share purchases. In consideration for entering into the Purchase Agreement, concurrent with the execution of the Purchase Agreement, the Company issued to 74,548 shares of its common stock to Aspire for no consideration The fair value of the 74,548 shares of common stock along with the direct costs incurred in the connection with the Aspire transaction have been allocated to the shares sold at inception of this agreement and the right to sell additional shares in the future based on the ratio of shares sold at inception to the total shares subject to this agreement. As a result, the Company recorded an expense of $0.4 million on its consolidated statements of operations for the year ended December 31, 2012.

The Company has accounted for the right to sell additional shares based on the guidance of ASC 815, Derivative Financial Instruments (“ASC 815”), which requires the instrument to be measured at fair value with changes in fair value reported in earnings. The instrument was deemed to have had minimal fair value at inception and such value is not expected to change throughout the term of the agreement as shares sold upon exercise are priced at an amount slightly lower than the fair value at the time of sale.

Economic Rights

On March 22, 2012, the Company entered into a financing agreement with certain existing institutional stockholders. Under the terms of the agreement, investors received contractual rights to receive cash equal to 10% of any future litigation settlement related to the specified intellectual property, subject to a cap. In certain defined situations, the Company may have to issue either additional common shares or warrants (collectively, the “Economic Rights”).

The Economic Rights are accounted for as a derivative financial instrument under ASC 815 and are measured at fair value. Changes in fair value are recognized in earnings. The fair value of the Economic Rights has been estimated using a decision-tree analysis method. This is an income-based method that incorporates the expected benefits, costs and probabilities of contingent outcomes under varying scenarios. Each scenario within the decision-tree is discounted to the present value using the company’s credit adjusted risk-free rate and ascribed a weighted probability to determine the fair value.

The Company has concluded the fair value of this liability was approximately $1.1 million as of December 31, 2012. The fair value of the Economic Rights increased approximately $23,000 since the inception of the agreement on March 22, 2012. Decreases and increases in the valuation of Economic Rights are recognized in the consolidated statement of operations as gains and losses, respectively.

The most significant inputs in estimating the fair value of this liability are:

(i) The Company’s credit adjusted risk-free rate, which has been derived from the observable returns on debt for more developed pharmaceuticals companies, adjusted for the Company’s risk profile.

(ii) The amount of the return to the investors, which will vary depending on:

a. The outcome of the litigation, including consideration of whether the litigation may be resolved in a jury trial or settled out of court;

b. The amount of the settlement or award, which the Company has estimated predominantly based on observable royalty rates arising from the settlement of other cases of intellectual property litigation; and

c. The form of the settlement or award.

(iii) The projected timing of the cash flows to the investors, which could vary between several months to several years depending upon whether the litigation is settled, when the court may decide the case, whether any appeal is made on any court decision and the form of any settlement or award.

(iv) The number of contingent warrants that could be issued, which is based on a formula.

The decision-tree analysis model used to calculate the fair value of the derivative requires the probability of alternative scenarios to be determined at a series of decision points. Each scenario may contain more than one decision point resulting in further scenarios. Therefore, the probability estimates made by management at each decision point are a significant input to the valuation model.

All of these inputs are unobservable inputs, which have an interrelated effect on the fair value of the derivative. It is not possible to evaluate the impact on the fair value of each factor in combination. However, generally the fair value of the derivative liability will increase, (i) the higher the value of the expected settlement or award, (ii) the lower the discount rate employed and (iii) the more likely it is that a settlement or award will be made. The fair value of the derivative liability will decrease if the timing of settlement is delayed, the expected settlement decreases, or anticipated litigation costs increase. The impact on the fair value of the derivative liability related to the probability of whether the litigation is settled prior to the court hearing or whether a settlement award is made by the court and the form of the settlement will depend on the other factors above and cannot be estimated in isolation.

The decision-tree analysis model has been performed by valuation specialists, based on inputs provided by the Company and other sources. At each reporting period, the inputs to the model will be evaluated to determine whether any adjustments are appropriate, and to reflect changes in the time value of the expected cash flows.

The Company used the following assumptions to calculate the value of the Economic Rights:

		December 31,
		2012
Probability of unsuccessful/successful outcomes		25% - 75%
Amount of award or settlement (1)		$10.0 million - $20.0 million
Discount rate		17.5%
Timing of cash flows		0.75 — 1.50 years
Royalty rate		6%
Litigation expenses		$3.0 million

(1) Assumptions take into consideration the cap on the amount that the Company would have to pay investors in the event of an award or settlement.

On March 6, 2013, the litigation for which the Economic Rights are associated was stayed for 30 days. There can be no assurance as to future scheduling if ordered by the Court if the stay terminates without a resolution to the case. In the event this matter is resolved at any time after December 31, 2012, such resolution may be materially different than the amounts estimated as of December 31, 2012 in connection with the valuation of the Economic Rights.

Other Liabilities Measured at Fair Value

Warrants Liability

The Company issued warrants to purchase shares of common stock under the registered direct financing completed in February 2007. These warrants are being accounted for as a liability in accordance with ASC 815. At the date of the transaction, the fair value of the warrants of $6.8 million was determined utilizing the Black-Scholes option pricing model utilizing the following assumptions: risk free interest rate — 4.68%, expected volatility — 85%, expected dividend yield — 0%, and a remaining contractual life of 7 years. As of December 31, 2012, the fair value of the warrants is zero based on the high exercise price of the warrants relative to the Company’s stock price at December 31, 2012 and the remaining term of 1.13 years. The fair value of the warrant is remeasured each reporting period, with a gain or loss recognized in the consolidated statement of operations. Such gains or losses will continue to be reported until the warrants are exercised or expired.

The Company recognized the change in the value of warrants as a gain on the consolidated statement of operations of $0.6 million and approximately $51,000 for the year ended December 31, 2011 and 2012, respectively.

Scottish Enterprise Agreement

On June 22, 2009, the Company amended the Agreement with Scottish Enterprise (“SE”) (the “Amendment”), in order to allow the Company to implement a reduction of the Company’s research operations located in Scotland in exchange for the parties’ agreement to modify the payment terms of the Agreement in the principal amount of £5 million (approximately $8.0 million at December 31, 2009), which SE had previously entered into with the Company. The Agreement provided for repayment of up to £5 million in the event the Company significantly reduced its Scottish research operations. Pursuant to the terms of the Amendment, in association with Cyclacel’s material reduction in staff at its Scottish research facility, the parties agreed to a modified payment of £1 million (approximately $1.7 million at June 22, 2009) payable in two equal tranches. On July 1, 2009, the first installment of £0.5 million (approximately $0.8 million) was paid and the remaining amount of £0.5 million (approximately $0.8 million) was paid on January 6, 2010.

In addition, should a further reduction below current minimum staff levels be effectuated before July 2014 without SE’s prior consent, the Company may be obligated to pay up to £4 million to SE, which will be calculated as a maximum of £4 million (approximately $6.2 million at December 31, 2011 and $6.5 million at December 31, 2012) less the market value of the shares held by SE at the time staffing levels in Scotland fall below the prescribed minimum levels. If the Company were to have reduced staffing levels below the prescribed levels, the amount potentially payable to SE would have been approximately £3.8 million (approximately $5.9 million) and approximately £3.8 million (approximately $6.1 million) at December 31, 2011 and December 31, 2012, respectively.

This arrangement is accounted for as a liability under ASC Topic 480, Distinguishing Liabilities from Equity (“ASC 480”), and is measured at fair value. Changes in fair value are recognized in earnings. Due to the nature of the associated contingency and the likelihood of occurrence, the Company has concluded the fair value of this liability was approximately $20,000 at December 31, 2011 and December 31, 2012, respectively. The most significant inputs in estimating the fair value of this liability are the probabilities that staffing levels fall below the prescribed minimum and that the Company is unable or unwilling to replace such employees within the prescribed time period. At both December 31, 2011 and 2012, the Company used a scenario analysis model to arrive at the fair value of the Scottish Enterprise Agreement and assumed a 30% probability of falling below a minimum staffing level and a 1% probability that the occurrence of such an event would not be cured within the prescribed time period. At each reporting period, the inputs used to determine the fair value of the liability will be evaluated to determine whether adjustments are appropriate. Changes in the value of this liability are recorded in the consolidated statement of operations.

- Definition

The entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 820
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=7578670&loc=d3e19207-110258

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 825
-SubTopic 10
-Section 50
-Paragraph 30
-URI http://asc.fasb.org/extlink&oid=6957238&loc=d3e14172-108612

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 825
-SubTopic 10
-Section 50
-Paragraph 21
-URI http://asc.fasb.org/extlink&oid=7491637&loc=d3e13537-108611

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 825
-SubTopic 10
-Section 50
-Paragraph 28
-URI http://asc.fasb.org/extlink&oid=6957238&loc=d3e14064-108612

Reference 5: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 825
-SubTopic 10
-Section 50
-Paragraph 16
-URI http://asc.fasb.org/extlink&oid=7491637&loc=d3e13504-108611

Reference 6: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 825
-SubTopic 10
-Section 50
-Paragraph 10
-URI http://asc.fasb.org/extlink&oid=7491637&loc=d3e13433-108611

Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 107
-Paragraph 15B
-Subparagraph a, b
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 8: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 133
-Paragraph 44A, 44B
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 9: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 159
-Paragraph 17-22, 27, 28
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 10: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 107
-Paragraph 15A
-Subparagraph a-d
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 11: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 107
-Paragraph 15C, 15D
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 12: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 157
-Paragraph 32, 33, 34
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 13: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 107
-Paragraph 3, 10, 14, 15
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

+ Details

Prepaid Expenses and Other Current Assets

12 Months Ended

Dec. 31, 2012

Prepaid Expenses and Other Current Assets

Prepaid Expenses and Other Current Assets

7 Prepaid Expenses and Other Current Assets

The following is a summary of prepaid expenses and other current assets at December 31, 2011 and 2012:

	December 31,
	2011	2012
	$000	$000
Research and development tax credit receivable	544	1,033
Prepayments	317	358
Deposits	—	153
Other current assets	208	55
	1,069	1,599

Property, Plant and Equipment

12 Months Ended

Dec. 31, 2012

Property, Plant and Equipment

Property, Plant and Equipment

8 Property, Plant and Equipment

Property, plant and equipment consisted of the following:

	Useful lives in years from	December 31,
	date of acquisition	2011		2012
		$000		$000
Leasehold improvements	5 to 15 yrs	844		867
Research and laboratory equipment	3 to 5 yrs	6,251		5,519
Office equipment and furniture	3 to 5 yrs	1,273		1,325
		8,368		7,711
Less: accumulated depreciation and amortization		(8,201	)	(7,582	)
		167		129

The depreciation and amortization of property, plant and equipment amounted to $0.5 million, $0.2 million and approximately $60,000 for the years ended December 31, 2010, 2011 and 2012, respectively.

Depreciation and amortization expense for the period from inception or August 13, 1996 through December 31, 2011 was $12.6 million. At December 31, 2011 and 2012 there were no assets held under capital lease arrangements.

- Definition

The entire disclosure for long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale. Examples include land, buildings, machinery and equipment, and other types of furniture and equipment including, but not limited to, office equipment, furniture and fixtures, and computer equipment and software. This disclosure may include property plant and equipment accounting policies and methodology, a schedule of property, plant and equipment gross, additions, deletions, transfers and other changes, depreciation, depletion and amortization expense, net, accumulated depreciation, depletion and amortization expense and useful lives, income statement disclosures, assets held for sale and public utility disclosures.

+ References + Details

Accrued and Other Current Liabilities

12 Months Ended

Dec. 31, 2012

Accrued and Other Current Liabilities

Accrued and Other Current Liabilities

9 Accrued and Other Current Liabilities

Accrued and other current liabilities consisted of the following:

	December 31,
	2011	2012
	$000	$000
Accrued research and development	3,471	3,623
Accrued legal and professional fees	232	1,118
Other current liabilities	480	860
	4,183	5,601

Commitments and Contingencies

12 Months Ended

Dec. 31, 2012

Commitments and Contingencies

Commitments and Contingencies

10 Commitments and Contingencies

General

Please refer to Note 4 — Significant Contracts for further discussion of certain of the Company’s commitments and contingencies.

Leases

The following is a summary of the Company’s contractual obligations and commitments relating to its facilities leases as at December 31, 2012:

		Operating lease obligations
		$000
2013		584
2014		584
2015		572
2016		567
2017		439
Thereafter		3,223
Total		5,969

Rent expense, which includes lease payments related to the Company’s research and development facilities and corporate headquarters and other rent related expenses, was $0.9 million for the year ended December 31, 2010 and $0.6 million for each of the years ended December 31, 2011 and 2012.

In October 2000, the Company entered into a twenty-five year lease for its research and development facility in Dundee, Scotland. In May 2011, the Company extended its lease for office space at its headquarters in Berkeley Heights, New Jersey, for an additional five years.

Please refer to Note 6 — “Fair Value” for further discussion of certain of the Company’s commitments and contingencies.

Purchase Obligations

At December 31, 2011, the Company had obligations in relation to the purchase of manufactured products within the ALIGN business of $0.2 million. As discussed in Note 3 — Discontinued Operations, the Company terminated the distribution agreements related to the ALIGN products effective September 30, 2012.

Preferred Dividends

The Company’s Board of Directors considers numerous factors in determining whether to declare the quarterly dividend pursuant to the certificate of designation governing the terms of the Company’s outstanding 6% Convertible Exchangeable Preferred Stock, including the requisite financial analysis and determination of a surplus. Accrued and unpaid dividends in arrears on preferred stock were $1.6 million, or $1.30 per share of preferred stock, as of December 31, 2011 and $2.3 million, or $1.90 per share, of preferred stock, as of December 31, 2012.

Legal proceedings

On April 27, 2010, the Company was served with a complaint filed by Celgene Corporation in the United States District Court for the District of Delaware seeking a declaratory judgment that four of the Company’s own patents, claiming the use of romidepsin injection in T-cell lymphomas, are invalid and not infringed by Celgene’s products, but directly involve the use and administration of Celgene’s ISTODAX® (romidepsin for injection) product. On June 17, 2010, the Company filed its answer and counterclaims to the declaratory judgment complaint. The Company has filed counterclaims charging Celgene with infringement of each of its four patents and seeking damages for Celgene’s infringement as well as injunctive relief. The four patents directly involve the use and administration of Celgene’s ISTODAX® (romidepsin for injection) product.

On March 6, 2013, the United States District Court for the District of Delaware “So Ordered” a Stipulation and Order For Stay as to all pending dates on the court’s calendar for a period of 30 days. This stay relates to all proceedings, including the Markman (or claim construction ) hearing previously scheduled for March 14, 2013.

- Definition

The entire disclosure for commitments and contingencies.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 825
-SubTopic 20
-Section 50
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=6449706&loc=d3e16207-108621

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 460
-SubTopic 10
-Section 50
-Paragraph 8
-URI http://asc.fasb.org/extlink&oid=6398077&loc=d3e12565-110249

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
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-URI http://asc.fasb.org/extlink&oid=6952336&loc=d3e14435-108349

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02.25)
-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

Reference 5: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 440
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=6394976&loc=d3e25287-109308

Reference 6: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name FASB Interpretation (FIN)
-Number 14
-Paragraph 3
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 5
-Paragraph 9, 10, 11, 12
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

+ Details

Stockholders' Equity

12 Months Ended

Dec. 31, 2012

Stockholders' Equity

Stockholders' Equity

11 Stockholders’ Equity

Preferred stock

As of December 31, 2012, there were 1,213,142 shares of Preferred Stock issued and outstanding at an issue price of $10.00 per share. Dividends on the Preferred Stock are cumulative from the date of original issuance at the annual rate of 6% of the liquidation preference of the Preferred Stock, payable quarterly on the first day of February, May, August and November, commencing February 1, 2005. Any dividends must be declared by the Company’s Board of Directors and must come from funds that are legally available for dividend payments. The Preferred Stock has a liquidation preference of $10 per share, plus accrued and unpaid dividends.

The Preferred Stock is convertible at the option of the holder at any time into the Company’s shares of common stock at a conversion rate of approximately 0.06079 shares of common stock for each share of Preferred Stock based on a price of $164.50. The Company has reserved 73,747 shares of common stock for issuance upon conversion of the remaining shares of Preferred Stock outstanding at December 31, 2012. The shares of previously-converted Preferred Stock have been retired, cancelled and restored to the status of authorized but unissued shares of preferred stock, subject to reissuance by the Board of Directors as shares of Preferred Stock of one or more series.

The Company may automatically convert the Preferred Stock into common stock if the closing price of the Company’s common stock has exceeded $246.75, which is 150% of the conversion price of the Preferred Stock, for at least 20 trading days during any 30-day trading period, ending within five trading days prior to notice of automatic conversion.

The Certificate of Designations governing the Preferred Stock provides that if the Company fails to pay dividends on its Preferred Stock for six quarterly periods, holders of Preferred Stock are entitled to nominate and elect two directors to the Company’s Board of Directors. This right accrued to the holders of Preferred Stock as of August 2, 2010 and two directors were nominated and elected at the annual meeting held on May 24, 2011.

The Preferred Stock has no maturity date and no voting rights prior to conversion into common stock, except under limited circumstances.

The Company may, at its option, redeem the Preferred Stock in whole or in part, out of funds legally available at the redemption prices per share stated below, plus an amount equal to accrued and unpaid dividends up to the date of redemption:

Year from November 1, 2012 to October 31, 2013	$	10.12
Year from November 1, 2013 to October 31, 2014	$	10.06
November 1, 2014 and thereafter	$	10.00

The Preferred Stock is exchangeable, in whole but not in part, at the option of the Company on any dividend payment date beginning on November 1, 2005 (the “Exchange Date”) for the Company’s 6% Convertible Subordinated Debentures (“Debentures”) at the rate of $10 principal amount of Debentures for each share of Preferred Stock. The Debentures, if issued, will mature 25 years after the Exchange Date and have terms substantially similar to those of the Preferred Stock. No such exchanges have taken place to date.

Conversion of Convertible Preferred Stock

During 2010, Cyclacel entered into agreements to exchange the Company’s Preferred Stock into shares of common stock. There were no exchanges of the Company’s Preferred Stock into shares of common stock during the year ended December 31, 2011 or 2012. The table below provides details of the aggregate activities in 2010:

		Year ended December 31, 2010
Preferred shares exchanged		833,671
Common shares issued:
At stated convertible option		50,679
Incremental shares issued under the exchange transaction		185,835
Total common shares issued		236,514

As the Preferred Stock stockholders received additional shares of common stock issued to them upon conversion as compared to what they would have been entitled to receive under the stated rate of exchange, the Company recorded the excess of (1) the fair value of all securities and other consideration transferred to the holders of the Preferred Stock and (2) the fair value of securities issuable pursuant to the original conversion terms as an increase in the net loss attributable to common shareholders. Specifically, the Company recorded deemed dividends related to the additional shares issued under the exchange transactions of $3.5 million for the year ended December 31, 2010.

Common Stock

December 2012 Stock Purchase Agreement

On December 14, 2012, the Company entered into a common stock purchase agreement with Aspire. Upon execution of the Purchase Agreement, Aspire purchased 158,982 shares of common stock for an aggregate purchase price of $1.0 million based the closing price of the Company’s common stock December 13, 2012, the date upon which the business terms were agreed. Under the terms of the Purchase Agreement, Aspire has committed to purchase up to an additional 1,455,787 shares from time to time as directed by the Company over the next two years at prices derived from the market prices on or near the date of each sale. However, such commitment is limited to an additional $19.0 million of share purchases. In consideration for entering into the Purchase Agreement, concurrent with the execution of the Purchase Agreement, the Company issued to 74,548 shares of its common stock to Aspire for no consideration. The fair value of the 74,540 shares of common stock along with the direct costs incurred in the connection with the Aspire transaction have been allocated to the shares sold at inception of this agreement and the right to sell additional shares in the future based on the ratio of shares sold at inception to the listed shares subject to this agreement. As a result, the Company recorded an expense of $0.4 million on its consolidated statements of operations for the year ended December 31, 2012.

March 2012 Sale of Common Stock and Economic Rights

On March 22, 2012, the Company entered into a purchase agreement with certain existing institutional stockholders, raising approximately $2.9 million of proceeds, net of certain fees and expenses. The proceeds from the financing will be used to fund ongoing litigation-related expenses on certain intellectual property and for general corporate purposes.

Under the terms of the purchase agreement, the investors purchased 669,726 shares of the Company’s common stock at a price of $4.53, which is equal to the 10-day average closing price of the Company’s common stock for the period ending on March 21, 2012. In addition to the common stock, investors received contractual rights to receive cash equal to 10% of any future litigation settlement related to the specified intellectual property, subject to a cap. In certain defined situations, the Company may have to issue either additional shares or warrants. The shares issued at closing are subject to a lock-up period of one year from the date of issuance. See Note 6 - Fair Value for further details.

July 2011 Underwritten Offering

On July 7, 2011, the Company closed an underwritten offering for an aggregate of 1,088,235 units, at an offering price of $9.52 per unit, for gross proceeds of approximately $10.4 million. Each unit consists of (i) one share of common stock and (ii) a five-year warrant to purchase 0.5 of a share of common stock at an exercise price of $9.52 per share, exercisable beginning six months after the date of issuance. The shares of common stock and warrants were immediately separable. As of December 31, 2012, all warrants issued to the investors in connection with this financing were outstanding and have been classified as equity. The transaction date fair value of the warrants of approximately $3.5 million was determined utilizing the Black-Scholes option pricing model utilizing the following assumptions: risk free interest rate — 1.74%, expected volatility - 99%, expected dividend yield - 0%, and a remaining contractual life of 5.00 years. Net proceeds of approximately $9.3 million, after underwriting discounts and commissions and other fees and expenses of approximately $1.1 million, were allocated based on relative transaction date fair values in the following manner: $6.8 million ($6.23 per share) and $2.5 million ($4.62 per warrant) to common shares and warrants, respectively.

October 2010 Private Placement

On October 7, 2010, the Company completed a private placement pursuant to which it sold approximately $15.2 million of its units to several institutional investors, for net proceeds of approximately $14.0 million. The units consist of one share of common stock and 0.5 of a warrant, with each whole warrant representing the right to purchase one share of common stock at an exercise price of $13.44 per share for a period of five years. As of December 31, 2012, all options and warrants issued to the investors are outstanding and have been classified as equity. The investors purchased a total of 1,189,027 units at a price of $12.78 per unit. The investors also had the right to acquire up to 594,513 additional units at a price of $11.69 per unit (for $6.9 million in gross proceeds) at any time up to nine months after closing or by July 6, 2011. As of December 31, 2012, none of the additional units had been exercised and, as of July 6, 2011, the right to acquire the additional units lapsed. The transaction date fair value of the warrants and additional optional units was $5.1 million and $2.8 million, respectively. Net proceeds of approximately $14.0 million were allocated based on relative transaction date fair values in the following manner: $8.9 million ($7.49 per share), $3.3 million ($5.53 per warrant) and $1.8 million ($3.01 per optional unit) to common shares, warrants and the additional optional units, respectively.

January 2010 Registered Direct Financings

On January 25, 2010, the Company completed the sale of 335,714 units in a “registered direct” offering at a purchase price of $17.50 per unit to certain institutional investors of the Company for gross proceeds of approximately $5.9 million. Each unit consisted of one share of the Company’s common stock and one warrant to purchase 0.30 of one share of its common stock. The warrants have a five-year term from the date of issuance, are exercisable beginning six months from the date of issuance at an exercise price of $19.95 per share of common stock. As of December 31, 2012, warrants issued to the investors have been classified as equity. The transaction date fair value of the warrants of $1.0 million was determined utilizing the Black-Scholes option pricing model utilizing the following assumptions: risk free interest rate - 2.39%, expected volatility - 90%, expected dividend yield - 0%, and a remaining contractual life of 5.00 years. As of December 31, 2012, all the warrants are outstanding. Net proceeds of approximately $5.4 million were allocated based on relative transaction date fair values in the following manner: $4.5 million ($13.51 per share) to common shares and $0.9 million ($9.03 per warrant) to the warrants.

On January 13, 2010, the Company completed the sale of 407,143 units in a “registered direct” offering to certain institutional investors. Each unit was sold at a purchase price of $17.57 per unit and consists of one share of the Company’s common stock and one warrant to purchase 0.25 of one share of its common stock for gross proceeds of approximately $7.2 million. The warrants have a five-year term from the date of issuance, are exercisable beginning six months from the date of issuance at an exercise price of $22.82 per share of common stock. As of December 31, 2012, warrants issued to the investors have been classified as equity. The transaction date fair value of the warrants of $1.3 million was determined utilizing the Black-Scholes option pricing model utilizing the following assumptions: risk free interest rate - 2.55%, expected volatility - 90%, expected dividend yield - 0%, and a remaining contractual life of 5.00 years. As of December 31, 2012, all the warrants are outstanding. Net proceeds of approximately $6.5 million were allocated based on relative transaction date fair values in the following manner: $5.6 million ($13.65 per share) to common shares and $0.9 million ($9.24 per warrant) to the warrants.

July 2009 Registered Direct Financing

On July 29, 2009, the Company sold its securities to select institutional investors consisting of 571,429 units in a “registered direct” offering at a purchase price of $5.95 per unit. Each unit consisted of (i) one share of the Company’s common stock, (ii) one warrant to purchase 0.625 of one share of common stock (a “Series I Warrant”) and (iii) one warrant to purchase 0.1838805 of one share of common stock (a “Series II Warrant”). The Series I Warrants had a seven-month term from the date of issuance, were exercisable beginning six months from the date of issuance at an exercise price of $7.00 per share of common stock. During the first quarter of 2010, all of the Series I Warrants were exercised for $2.5 million. The Series II Warrants have a five-year term from the date of issuance, are exercisable beginning six months from the date of issuance at an exercise price of $7.00 per share of common stock. During the first quarter of 2010, 6,181 common shares were issued upon exercise of Series II Warrants with proceeds of $43,266. There were no exercises during the year ended December 31, 2011 or 2012.

The net proceeds to the Company from the sale of the units, after deducting for the placement agent’s fees and offering expenses, were approximately $2.9 million. As of December 31, 2012, the remaining Series II Warrants outstanding and exercisable into 98,893 of the Company’s shares of common stock have been classified as equity. The transaction date fair value of the Series II Warrants of $0.6 million was determined utilizing the Black-Scholes option pricing model utilizing the following assumptions: risk free interest rate - 2.69%, expected volatility - 90%, expected dividend yield - 0%, and a remaining contractual life of 5.00 years.

December 2007 Committed Equity Financing Facility or CEFF

On December 10, 2007 and as amended on November 24, 2009, Cyclacel entered into a Committed Equity Financing Facility, or CEFF, with Kingsbridge, in which Kingsbridge committed to purchase the lesser of 583,513 shares of common stock or $60 million of common stock from Cyclacel over a three-year period. The CEFF lapsed on December 10, 2010.

During the year ended December 31, 2010, the Company sold 402,704 shares of its common stock to Kingsbridge under the CEFF, in consideration of aggregate proceeds of $4.9 million.

Common Stock Warrants

In connection with the Company’s February 16, 2007 “registered direct” offering, the Company issued to investors warrants to purchase 151,773 shares of common stock. The warrants issued to the investors are being accounted for as a liability. At the date of the transaction, the fair value of the warrants of $6.8 million was determined utilizing the Black-Scholes option pricing model utilizing the following assumptions: risk free interest rate - 4.58%, expected volatility - 85%, expected dividend yield - 0%, and a remaining contractual life of 6.88 years. The value of the warrant is being marked to market each reporting period as a derivative gain or loss on the consolidated statement of operations until exercised or expiration. At December 31, 2011 the fair value of the warrants determined utilizing the Black-Scholes option pricing model was approximately $0.1. The Company determined that the warrants had no value at December 31, 2012 because of the market price of the Company’s common stock compared to the exercise price of the warrants and the expiration of the warrants in February 2014. The Company recognized the change in the value of warrants of $0.6 million and approximately $51,000 as gains on the consolidated statements of operations for the years ended December 31, 2011 and 2012, respectively.

The following table summarizes information about warrants outstanding at December 31, 2012:

Issued in Connection With	Expiration Date	Common Shares Issuable	Weighted Average Exercise Price
April 2006 stock issuance	2013	367,347	$	49.00
February 2007 stock issuance	2014	151,773	$	59.08
December 2007 CEFF	2013	14,285	$	9.80
July 2009 Series II stock issuance	2014	98,893	$	7.00
January 2010 stock issuance	2015	101,785	$	22.82
January 2010 stock issuance	2015	100,714	$	19.95
October 2010 stock issuance	2015	594,513	$	13.44
July 2011 stock issuance	2016	544,117	$	9.52
Total		1,973,427	$	22.96

Exercise of Stock Options

During the year ended December 31, 2011, 948 shares of common stock were issued from the exercise of stock options resulting in proceeds of approximately $3,000. During the year ended December 31, 2012, there were 33,351 stock option exercises totaling approximately $0.1 million.

- Definition

The entire disclosure for shareholders' equity, comprised of portions attributable to the parent entity and noncontrolling interest, if any, including other comprehensive income (as applicable). Including, but not limited to: (1) balances of common stock, preferred stock, additional paid-in capital, other capital and retained earnings; (2) accumulated balance for each classification of other comprehensive income and total amount of comprehensive income; (3) amount and nature of changes in separate accounts, including the number of shares authorized and outstanding, number of shares issued upon exercise and conversion, and for other comprehensive income, the adjustments for reclassifications to net income; (4) rights and privileges of each class of stock authorized; (5) basis of treasury stock, if other than cost, and amounts paid and accounting treatment for treasury stock purchased significantly in excess of market; (6) dividends paid or payable per share and in the aggregate for each class of stock for each period presented; (7) dividend restrictions and accumulated preferred dividends in arrears (in aggregate and per share amount); (8) retained earnings appropriations or restrictions, such as dividend restrictions; (9) impact of change in accounting principle, initial adoption of new accounting principle and correction of an error in previously issued financial statements; (10) shares held in trust for Employee Stock Ownership Plan (ESOP); (11) deferred compensation related to issuance of capital stock; (12) note received for issuance of stock; (13) unamortized discount on shares; (14) description, terms, and number of warrants or rights outstanding; (15) shares under subscription and subscription receivables, effective date of new retained earnings after quasi-reorganization and deficit eliminated by quasi-reorganization and, for a period of at least ten years after the effective date, the point in time from which the new retained dates; and (16) retroactive effective of subsequent change in capital structure.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08.(d),(e))
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Reference 2: http://www.xbrl.org/2003/role/presentationRef
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Reference 3: http://www.xbrl.org/2003/role/presentationRef
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Reference 4: http://www.xbrl.org/2003/role/presentationRef
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Reference 5: http://www.xbrl.org/2003/role/presentationRef
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Reference 6: http://www.xbrl.org/2003/role/presentationRef
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Reference 7: http://www.xbrl.org/2003/role/presentationRef
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Reference 8: http://www.xbrl.org/2003/role/presentationRef
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Reference 9: http://www.xbrl.org/2003/role/presentationRef
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Reference 11: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
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Reference 12: http://www.xbrl.org/2003/role/presentationRef
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Reference 14: http://www.xbrl.org/2003/role/presentationRef
-Publisher AICPA
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-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 15: http://www.xbrl.org/2003/role/presentationRef
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Reference 16: http://www.xbrl.org/2003/role/presentationRef
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Reference 18: http://www.xbrl.org/2003/role/presentationRef
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Reference 19: http://www.xbrl.org/2003/role/presentationRef
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Reference 20: http://www.xbrl.org/2003/role/presentationRef
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Reference 21: http://www.xbrl.org/2003/role/presentationRef
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Reference 23: http://www.xbrl.org/2003/role/presentationRef
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-Name Regulation S-X (SX)
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+ Details

Stock-Based Compensation Arrangements

12 Months Ended

Dec. 31, 2012

Stock-Based Compensation Arrangements

Stock-Based Compensation Arrangements

12 Stock-Based Compensation Arrangements

All stock-based compensation information presented gives effect to the reverse stock split, which occurred on August 24, 2012.

ASC 718 requires compensation expense associated with share-based awards to be recognized over the requisite service period, which for the Company is the period between the grant date and the date the award vests or becomes exercisable. Most of the awards granted by the Company (and still outstanding), vest ratably over four years, with ¼ of the award vesting one year from the date of grant and 1/48 of the award granted vesting each month thereafter. Annual awards granted in December 2010 vest 1/48 of the award each month after the grant date. Certain awards made to executive officers vest over three to five years, depending on the terms of their employment with the Company.

The Company recognizes all share-based awards issued after the adoption of ASC 718 under the straight-line attribution method. ASC 718 requires forfeitures to be estimated at the time of grant and revised, if necessary, in subsequent periods if actual forfeitures differ from those estimates. The Company evaluates its forfeiture assumptions quarterly and the expected forfeiture rate is adjusted when necessary. Ultimately, the actual expense recognized over the vesting period is based on only those shares that vest.

Stock based compensation has been reported within expense line items on the consolidated statement of operations for 2010, 2011 and 2012 as shown in the following table:

	Year ended December 31, 2010	Year ended December 31, 2011	Year ended December 31, 2012
	$000	$000	$000
Research and development	351	171	71
General and administrative	1,344	669	266
(Loss) income from discontinued operations, net of tax	51	42	43
Stock-based compensation costs before income taxes	1,746	882	380

2006 Plans

On March 16, 2006, Xcyte stockholders approved the adoption of the 2006 Plans, under which Cyclacel, may make equity incentive grants to its officers, employees, directors and consultants. At the Company’s annual shareholder meeting on May 23, 2012, the stockholders approved and amended the number of shares reserved under the 2006 Plan to 10,000,000 shares of the Company’s common stock, up from 5,200,000 shares. Stock option awards granted under the 2006 Plan have a maximum life of 10 years and generally vest over a four-year period from the date of grant.

The Company granted approximately 33,571 options to employees and directors with a grant date fair value of approximately $0.1 million, of which approximately $12,000 has been recorded as compensation cost in the consolidated statement of operations for the year ended December 31, 2012. During 2011, the Company granted approximately 28,500 options to employees and directors with a grant date fair value of approximately $0.2 million, of which approximately $24,000 has been recorded as compensation cost for the year ended December 31, 2011. During 2010, the Company granted approximately 0.1 million options to employees and directors with a grant date fair value of approximately $0.6 million, of which approximately $50,000 was expensed during the year ended December 31, 2010. The weighted average grant-date fair values of options granted during the year ended December 31, 2012, 2011, and 2010 were $2.52, $8.05, and $9.80, respectively.

As of December 31, 2012, the total remaining unrecognized compensation cost related to the non-vested stock options amounted to approximately $0.4 million, which will be amortized over the weighted-average remaining requisite service period of 2.27 years.

During the years ended December 31, 2010, 2011 and 2012, the Company did not settle any equity instruments with cash.

The Company received $0.1 million from the exercise of 33,351 options during 2012. The total intrinsic value of options exercised during 2012 was approximately $0.1 million. The Company received $3,000 from the exercise of 948 stock options during 2011. The total intrinsic value of options exercised during 2011 was approximately $7,000. The Company received approximately $0.1 million from the exercise of 24,901 stock options during 2010. The total intrinsic value of options exercised during 2010 was approximately $0.2 million. No income tax benefits were recorded for the years ended December 2010, 2011 and 2012 because ASC 718 prohibits recognition of tax benefits for exercised stock options until such benefits are realized. The Company was not able to benefit from the deduction for exercised stock options for the years ended December 31, 2010, 2011 and 2012 because the Company incurred tax losses in each of those years.

Outstanding Options

A summary of the share option activity and related information is as follows:

Cyclacel Pharmaceuticals, Inc.	Number of options outstanding		Weighted average exercise price		Weighted average remaining contractual term (years)	Aggregate intrinsic value
Options outstanding at December 31, 2010	498,562		$	27.72	7.22	$	938
Granted	28,500		$	10.64
Exercised	(948	)	$	2.87
Cancelled/forfeited	(23,865	)	$	40.53
Options outstanding at December 31, 2011	502,249		$	26.11	6.44	$	140
Granted	33,571		$	3.29
Exercised	(33,351	)	$	3.09
Cancelled/forfeited	(39,446	)	$	20.21
Options outstanding at December 31, 2012	463,023		$	26.61	5.58	347
Unvested at December 31, 2011	69,781		$	8.83	8.44	68
Vested and exercisable at December 31, 2012	393,242		$	29.77	5.07	279

The following table summarizes information about options outstanding at December 31, 2012:

Exercise price ($)	Number outstanding	Weighted Average remaining contractual life	Number exercisable
2.03 — 13.86	196,078	7.24	133,108
15.05 — 34.62	44,618	6.11	37,807
36.63 — 40.67	72,581	4.81	72,581
43.75 — 48.65	123,353	3.56	123,353
54.60 — 105.00	26,393	3.88	26,393
	463,023		393,242

The fair value of the stock options granted is calculated using the Black-Scholes option-pricing model as prescribed by ASC 718 using the following assumptions:

	Year ended December 31, 2010	Year ended December 31, 2011	Year ended December 31, 2012
Expected term (years)	5 — 6	5 — 6	6
Risk free interest rate	1.64 — 2.96%	1.47 — 2.29%	0.95%
Volatility	90 — 102%	93 — 99%	98%
Expected dividend yield over expected term	0.00%	0.00%	0.00%
Resulting weighted average grant date fair value	$9.80	$8.05	$2.52

The expected term assumption was estimated using past history of early exercise behavior and expectations about future behaviors. Starting with the December 2010 annual grants to the Company’s employees, the Company relied exclusively on its historical volatility as an input to the option pricing model as management believes that this rate will be representative of future volatility over the expected term of the options. Before December 2010, due to the Company’s limited existence of being a public company, the expected volatility assumption was based on the historical volatility of peer companies over the expected term of the option awards.

Estimates of pre-vesting option forfeitures are based on the Company’s experience. Currently the Company uses a forfeiture rate of 0 — 30% depending on when and to whom the options are granted. The Company adjusts its estimate of forfeitures over the requisite service period based on the extent to which actual forfeitures differ, or are expected to differ, from such estimates. Changes in estimated forfeitures are recognized through a cumulative adjustment in the period of change and may impact the amount of compensation expense to be recognized in future periods.

The Company considers many factors when estimating expected forfeitures, including types of awards, employee class, and historical experience. During the years ended December 31, 2010, 2011 and 2012, the Company recognized an expense of $0.5 million, an expense of approximately $0.2 million, and income of approximately $0.1 million, respectively, as a result of revised forfeiture rates.

The weighted average risk-free interest rate represents interest rate for treasury constant maturities published by the Federal Reserve Board. If the term of available treasury constant maturity instruments is not equal to the expected term of an employee option, Cyclacel uses the weighted average of the two Federal Reserve securities closest to the expected term of the employee option.

Restricted Stock

In November 2008, the Company issued 7,142 shares of restricted common stock to an employee subject to certain forfeiture provisions. Specifically, one quarter of the award vests one year from the date of grant and 1/48 of the award effectively vests each month thereafter. This restricted stock grant was accounted for at fair value at the date of grant and an expense is recognized during the vesting term. As of December 31, 2012, all of these awards have vested and there is no remaining unrecognized compensation cost. Summarized information for restricted stock activity for the years ended December 31, 2011 and 2012 is as follows:

	Restricted Stock		Weighted Average Grant Date Value Per Share
Non-vested at December 31, 2010	3,418		$	3.08
Vested	(1,786	)	$	3.08
Non-vested at December 31, 2011	1,632		$	3.08
Vested	(1,632	)	$	3.08
Non-vested at December 31, 2012	—		$	—

Restricted Stock Units

The Company issued 13,100, 34,000, and 12,281 restricted stock units, each of which entitles the holders to receive a share of the Company’s common stock, to senior executives of the Company in November 2008, December 2011, and to employees in January 2012 and February 2012. The 2008 grants vest over four years and the 2011 and 2012 grants vest over three years. A restricted stock unit grant is accounted for at fair value at the date of grant which is equivalent to the market price of a share of the Company’s common stock, and an expense is recognized over the vesting term. As of December 31, 2012, the total remaining unrecognized compensation cost related to the non-vested restricted stock amounted to $0.1 million, which will be amortized over the weighted-average remaining requisite service period of 1.97 years. Summarized information for restricted stock units activity for the years ended December 31, 2011 and 2012 is as follows:

	Restricted Stock Units		Weighted Average Grant Date Value Per Share
Non-vested at December 31, 2010	5,142		$	3.08
Granted	34,000		$	5.81
Vested	(2,679	)	$	3.08
Non-vested at December 31, 2011	36,463		$	5.60
Granted	12,281		$	3.85
Forfeited	(6,904	)	$	4.99
Vested	(2,463	)	$	3.08
Non-vested at December 31, 2012	39,377		$	5.34

- Definition

The entire disclosure for compensation-related costs for equity-based compensation, which may include disclosure of policies, compensation plan details, allocation of equity compensation, incentive distributions, equity-based arrangements to obtain goods and services, deferred compensation arrangements, employee stock ownership plan details and employee stock purchase plan details.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 50
-Section 50
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=6406099&loc=d3e25284-112666

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
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-Section 50
-Paragraph 1
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Reference 6: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Staff Accounting Bulletin (SAB)
-Number Topic 14

Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 123R
-Paragraph 64, 65, A240
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 8: http://www.xbrl.org/2003/role/presentationRef
-Publisher AICPA
-Name Statement of Position (SOP)
-Number 93-6
-Paragraph 53
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

+ Details

Employee Benefit Plans	12 Months Ended
Employee Benefit Plans	Dec. 31, 2012
Employee Benefit Plans
Employee Benefit Plans	13 Employee Benefit Plans Pension Plan The Company operates a defined contribution group personal pension plan for all of its U.K. based employees. Company contributions to the plan totaled approximately $0.2 million for the year ended December 31, 2009 and $0.1 million for the years ended December 31, 2011 and 2012. 401(k) Plan The 401(k) Plan provides for matching contributions by the Company in an amount equal to the lesser of 100% of the employee’s deferral or 6% of the U.S. employee’s qualifying compensation. The 401(k) Plan is intended to qualify under Section 401(k) of the Internal Revenue Code, so that contributions to the 401(k) Plan by employees or by the Company, and the investment earnings thereon, are not taxable to the employees until withdrawn. Company matching contributions are tax deductible by the Company when made. Company employees may elect to reduce their current compensation by up to the statutorily prescribed annual limit of $17,000 if under 50 years old and $22,500 if over 50 years old in 2012 and to have those funds contributed to the 401(k) Plan. For each of the years ended December 31, 2010, 2011 and 2012, the Company made contributions of approximately $0.1 million to the 401(k) Plan.

- Definition

The entire disclosure for pension and other postretirement benefits.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 715
-URI http://asc.fasb.org/topic&trid=2235017

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-Publisher FASB
-Name Implementation Guide (Q and A)
-Number FAS88
-Paragraph 63
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Reference 3: http://www.xbrl.org/2003/role/presentationRef
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-Name Statement of Financial Accounting Standard (FAS)
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Reference 4: http://www.xbrl.org/2003/role/presentationRef
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-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 5: http://www.xbrl.org/2003/role/presentationRef
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-Name Statement of Financial Accounting Standard (FAS)
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-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 6: http://www.xbrl.org/2003/role/presentationRef
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-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
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-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 8: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
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-Paragraph 5
-Subparagraph q
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 9: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
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-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 10: http://www.xbrl.org/2003/role/presentationRef
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-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 11: http://www.xbrl.org/2003/role/presentationRef
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-Name Statement of Financial Accounting Standard (FAS)
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Reference 12: http://www.xbrl.org/2003/role/presentationRef
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-Name Statement of Financial Accounting Standard (FAS)
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-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 13: http://www.xbrl.org/2003/role/presentationRef
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-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 14: http://www.xbrl.org/2003/role/presentationRef
-Publisher AICPA
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-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

+ Details

Taxes

12 Months Ended

Dec. 31, 2012

Taxes

Taxes

14 Taxes

(Loss) income before taxes from continuing operations is comprised of the following components for the years ended December 31, 2010, 2011 and 2012:

	Year ended December 31, 2010		Year ended December 31, 2011		Year ended December 31, 2012
	$000		$000		$000
Domestic	(3,533	)	904		(2,009	)
Foreign	(12,014	)	(16,072	)	(13,098	)
(Loss) income from continuing operations before taxes	(15,547	)	(15,168	)	(15,107	)

The benefit for income taxes from continuing operations consists of the following:

	Year ended December 31, 2010		Year ended December 31, 2011	Year ended December 31, 2012
	$000		$000	$000
Current — domestic	(10	)	—	—
Current — foreign	667		565	1,014
Current — total	657		565	1,014
Deferred — domestic	—		—	337
Income tax benefit	657		565		1,351

The Company has incurred a taxable loss in each of the operating periods since incorporation. The income tax credits of $0.7 million, $0.6 million and $1.4 million for the years ended December 31, 2010, 2011 and 2012, respectively, represent U.K. research and development (“R&D”) tax credits receivable against such expenditures in the United Kingdom that are refundable.

A reconciliation of the (benefit) provision for income taxes from continuing operations with the amount computed by applying the statutory federal tax rate to loss before income taxes is as follows:

	Year ended December 31, 2010		Year ended December 31, 2011		Year ended December 31, 2012
	$000		$000		$000
Loss before income taxes	(15,547	)	(15,168	)	(15,107	)

Income tax expense computed at statutory federal tax rate	(5,286	)	(5,157	)	(5,136	)
Disallowed expenses and non-taxable income	(490	)	(141	)	176
Loss surrendered to generate R&D credit	1,605		1,372		3,025
Additional research and development tax relief	(793	)	(2,260	)	(2,656	)
Change in valuation allowance	3,605		2,952		(579	)
Research and development tax credit rate difference	132		—		—
Foreign items, including change in tax rates	570		2,669		3,819
	(657	)	(565	)	(1,351	)

Significant components of the Company’s deferred tax assets are shown below:

	December 31,
	2011		2012
	$000		$000
Net operating loss carryforwards	43,870		42,399
Depreciation, amortization and impairment of property and equipment	1,772		1,654
Stock Options	1,372		1,451
Accrued Expenses	3,435		3,389
Other	96		45
Translation adjustment	249		1,277
Deferred Tax Assets	50,794		50,215
Valuation allowance for deferred tax assets	(50,794	)	(50,215	)
Net deferred taxes	—		—

Deferred income taxes reflect the net tax effect of temporary differences between the carrying amounts of assets and liabilities for financial reporting and tax purposes. A valuation allowance has been established, as realization of such assets is uncertain.

The Company’s management evaluated the positive and negative evidence bearing upon the realizability of its deferred assets, and has determined that, at present, the Company may not be able to recognize the benefits of the deferred tax assets under the more likely than not criteria. Accordingly, a valuation allowance of approximately $50 million has been established at December 31, 2012. The valuation allowance increased by approximately $3 million in 2011 and decreased by approximately $579 thousand in 2012.

In certain circumstances, as specified in the Tax Reform Act of 1986, due to ownership changes, the Company’s ability to utilize its NOL carryforwards may be limited. The benefit of deductions from the exercise of stock options is included in the net operating loss (“NOL”) carryforwards. The benefit from these deductions will be recorded as a credit to additional paid-in capital if and when realized through a reduction of cash taxes. As of December 31, 2011 and 2012, the Company had federal NOLs of $18.6 million and $19.2 million and foreign NOLs of $148.2 million and $153.4 million, respectively. The Company has federal NOLs that will start to expire in 2027, and state NOLs totaling $18.3 million will start expiring in 2023. The Company’s foreign NOL’s do not expire under U.K. tax law.

Utilization of the NOLs may be subject to a substantial annual limitation under Section 382 of the Internal Revenue Code of 1986 due to ownership change limitations that have occurred previously or that could occur in the future. These ownership changes may limit the amount of NOL and R&D credit carryforwards that can be utilized annually to offset future taxable income and tax, respectively. The Company has not currently completed a study to assess whether an ownership change has occurred, or whether there have been multiple ownership changes since the Company’s formation, due to the significant complexity and related cost associated with such study. Management has evaluated all significant tax positions at December 31, 2011 and 2012 and concluded that there are no material uncertain tax positions. The Company would recognize both interest and penalties related to unrecognized benefits in income tax expense. The Company has not recorded any interest and penalties on any unrecognized tax benefits since its inception.

Tax years 2010, 2011 and 2012 remain open to examination by major taxing jurisdictions to which the Company is subject, which are primarily in the United Kingdom and the United States, as carryforward attributes generated in years past may still be adjusted upon examination by the United Kingdom’s H.M. Revenue & Customs, the Internal Revenue Service (“IRS”) or state tax authorities if they have or will be used in a future period. The Company is currently not under examination by the IRS or any other jurisdictions for any tax years.

- Definition

The entire disclosure for income taxes. Disclosures may include net deferred tax liability or asset recognized in an enterprise's statement of financial position, net change during the year in the total valuation allowance, approximate tax effect of each type of temporary difference and carryforward that gives rise to a significant portion of deferred tax liabilities and deferred tax assets, utilization of a tax carryback, and tax uncertainties information.

+ References

+ Details

Geographic Information

12 Months Ended

Dec. 31, 2012

Geographic Information

Geographic Information

15 Geographic Information

Geographic information for the years ended December 31, 2010, 2011 and 2012 is as follows:

	Year ended December 31, 2010		Year ended December 31, 2011		Year ended December 31, 2012
	$000		$000		$000
Revenue
United Kingdom	112		—		69
Total Revenue	1		—		69
Net loss
United States:
Continuing operations	(3,531	)	565		(1,672	)
Discontinued operations	(1,131	)	(640	)	570
Total United States	(4,662	)	(75	)	(1,102	)
United Kingdom	(11,359	)	(15,168	)	(12,084	)
Total Net Loss	(16,021	)	(15,243	)	(13,186	)

	December 31,
	2011	2012
	$000	$000
Total Assets
United States:
Continuing operations	20,402	14,286
Discontinued operations	313	1,214
Total United States	20,715	15,500
United Kingdom	5,283	3,854
Total Assets	25,998	19,354

Long Lived Assets, net
United States:
Continuing operations	45	25
Discontinued operations	—	—
Total United States	45	25
United Kingdom	122	104
Total Long Lived Assets, net	167	129

- Definition

The entire disclosure for reporting segments including data and tables. Reportable segments include those that meet any of the following quantitative thresholds a) it's reported revenue, including sales to external customers and intersegment sales or transfers is 10 percent or more of the combined revenue, internal and external, of all operating segments b) the absolute amount of its reported profit or loss is 10 percent or more of the greater, in absolute amount of 1) the combined reported profit of all operating segments that did not report a loss or 2) the combined reported loss of all operating segments that did report a loss c) its assets are 10 percent or more of the combined assets of all operating segments.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 34
-URI http://asc.fasb.org/extlink&oid=6534315&loc=d3e8981-108599

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
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-Publisher FASB
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-Publisher FASB
-Name Accounting Standards Codification
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-Publisher FASB
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-Publisher FASB
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Reference 15: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 131
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

+ Details

Subsequent Events	12 Months Ended
Subsequent Events	Dec. 31, 2012
Subsequent Events
Subsequent Events	16 Subsequent Events Preferred Stock Dividend On January 11, 2013, the Company’s Board of Directors declared a quarterly cash dividend in the amount of $0.15 per share on the Company’s Preferred Stock with respect to the fourth quarter of 2012. The Company paid the dividend on February 1, 2013 to holders of record of the Preferred Stock as of the close of business on January 22, 3013. The Board considered numerous factors in determining whether to declare the quarterly dividend, including the requisite financial analysis and determination of a surplus. While the Board will analyze the advisability of the declaration of dividends in future quarters, there is no assurance that future quarterly dividends will be declared. Preferred Exchanges During the first quarter of 2013, the Company settled three separate Securities Exchange Agreements with its stockholders pursuant to which the Company agreed to issue 1,513,653 shares of its common stock to the preferred stockholders in exchange for their delivery to the Company of 792,460 shares of the Company’s Convertible Preferred Stock. As the Company issued 1,465,480 shares of common stock in excess of the number of shares the preferred stock was convertible into under the original conversion terms, we anticipate recording deemed dividends in the amount of approximately $8.4 million during the first quarter of 2013. As of a result of these transactions a total of 420,862 shares of Preferred Stock remain outstanding. Stock Purchase Agreement During the first quarter of 2013, the Company sold 650,000 shares of its common stock to Aspire Capital Fund, LLC under the Common Stock Purchase Agreement in consideration for an aggregate proceeds of $3.4 million.

Summary of Significant Accounting Policies (Policies)

12 Months Ended

Dec. 31, 2012

Summary of Significant Accounting Policies

Use of Estimates

Use of Estimates

Risks and Uncertainties

Risks and Uncertainties

Foreign currency and currency translation

Foreign currency and currency translation

Segments

Segments

Cash and Cash Equivalents

Cash and Cash Equivalents

Inventory

Inventory

Fair Value of Financial Instruments

Fair Value of Financial Instruments

Property, Plant and Equipment

Property, Plant and Equipment

Impairment of Long-lived Assets

Impairment of Long-lived Assets

Impairment, if any, is measured as the amount by which the carrying amount of a long-lived asset (or asset group) exceeds its fair value.

Revenue Recognition

Revenue Recognition

Product sales

Collaboration, research and development, and grant revenue

Clinical Trial Accounting

Clinical Trial Accounting

Research and Development Expenditures

Research and Development Expenditures

Patent Costs

Patent Costs

Patent prosecution costs are charged to operations as incurred as recoverability of such expenditure is uncertain.

Leased Assets

Leased Assets

The costs of operating leases are charged to operations on a straight-line basis over the lease term.

Income Taxes

Income Taxes

Net Loss Per Common Share

Net Loss Per Common Share

	Year ended December 31, 2010	Year ended December 31, 2011	Year ended December 31, 2012
Stock options	498,562	502,249	463,023
Restricted Stock and Restricted Stock Units	8,555	38,089	39,377
Convertible preferred stock	73,747	73,747	73,747
Contingently issuable shares and common stock warrants associated with Economic Rights	—	—	440,375
Options issued in connection with the October 2010 financing	891,771	—	—
Common stock warrants	1,429,313	1,973,431	1,973,427
Total shares excluded from calculation	2,901,948	2,587,516	2,989,949

Fair Value Measurements

Fair Value Measurements

Stock-based Compensation

Stock-based Compensation

Comprehensive Income (Loss)

Comprehensive Income (Loss)

Recent Accounting Pronouncements

Recent Accounting Pronouncements

Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2012

Summary of Significant Accounting Policies

Schedule of antidilutive shares excluded from computation of diluted net loss per share

	Year ended December 31, 2010	Year ended December 31, 2011	Year ended December 31, 2012
Stock options	498,562	502,249	463,023
Restricted Stock and Restricted Stock Units	8,555	38,089	39,377
Convertible preferred stock	73,747	73,747	73,747
Contingently issuable shares and common stock warrants associated with Economic Rights	—	—	440,375
Options issued in connection with the October 2010 financing	891,771	—	—
Common stock warrants	1,429,313	1,973,431	1,973,427
Total shares excluded from calculation	2,901,948	2,587,516	2,989,949

Discontinued Operations (Tables)

12 Months Ended

Dec. 31, 2012

Discontinued Operations

Schedule of assets and liabilities, and product revenue, cost of goods sold and selling, general and administrative costs of discontinued operations

	Year ended December 31, 2010			Year ended December 31, 2011			Year ended December 31, 2012			Period from August 13, 1996 (inception) to December 31, 2012
Product revenue	$	574		$	699		$	583		$	3,604
Cost of goods sold	(418		)	(360		)	(293		)	(2,045		)
Selling, general and administrative	(1,287		)	(979		)	(607		)	(9,295		)
Goodwill and intangible impairment	—			—			—			(5,187		)
Interest income	—			—			32			32
Interest expense	—			—			—			(110		)
Gain on termination of license agreement	—			—			1,192			1,192
(Loss) income from discontinued operations	(1,131		)	(640		)	907			(11,809		)
Income tax expense	—			—			(337		)	(337		)
(Loss) income from discontinued operations, net of tax	$	(1,131	)	$	(640	)	$	570		$	(12,146	)

	December 31, 2011		December 31, 2012

Current assets of discontinued operations:
Inventory	$	182	$	—
Short term portion of minimum royalty arrangement receivable, net	—		536
Returns indemnification receivable	—		325
Accounts receivable and other current assets	131		—
Total current assets of discontinued operations	313		861
Long-term assets of discontinued operations:
Long-term portion of minimum royalty arrangement receivable, net	—		353
Total assets of discontinued operations	313		1,214

Current liabilities of discontinued operations:
Accounts payable	$	46	$	10
Returns provision	202		325
Accrued liabilities and other current liabilities	279		—
Total current liabilities of discontinued operations	$	527	$	335

- Definition

Tabular disclosure of disposal groups, which may include the gain (loss) recognized in the income statement and the income statement caption that includes that gain (loss), amounts of revenues and pretax profit or loss reported in discontinued operations, the classification and carrying value of the assets and liabilities comprising the disposal group, and the segment in which the disposal group was reported. Also may include the amount of adjustments to amounts previously reported in discontinued operations such as resolution of contingencies arising from the disposal transaction or the operations of the component prior to disposal.

+ References + Details

Cash and Cash Equivalents (Tables)

12 Months Ended

Dec. 31, 2012

Cash and Cash Equivalents

Summary of cash and cash equivalents

	December 31,
	2011	2012
	$000	$000
Cash	4,555	4,090
Investments with original maturity of less than three months at the time of purchase	19,894	12,322
Total cash and cash equivalents	24,449	16,412

Fair Value (Tables)

12 Months Ended

Dec. 31, 2012

Fair Value

Schedule of financial assets and liabilities measured on a recurring basis

The fair value of the Company’s financial assets and liabilities that are measured on a recurring basis were determined using the following inputs as of December 31, 2011:

	Level 1	Level 2	Level 3	Total
	$000	$000	$000	$000
ASSETS
Cash equivalents	19,894	—	—	19,894
Total assets	19,894	—	—	19,894

LIABILITIES
Other liabilities measured at fair value:
Warrants liability	—	—	51	51
Scottish Enterprise agreement	—	—	20	20
Other liabilities measured at fair value	—	—	71	71
Total liabilities	—	—	71	71

The fair value of the Company’s financial assets and liabilities that are measured on a recurring basis were determined using the following inputs as of December 31, 2012:

	Level 1	Level 2	Level 3	Total
	$000	$000	$000	$000
ASSETS
Cash equivalents	5,523	6,799	—	12,322
Financial instrument associated with stock purchase agreement	—	—	—	—
Total assets	5,523	6,799	—	12,322

LIABILITIES
Economic rights	—	—	1,120	1,120
Other liabilities measured at fair value:
Warrants liability	—	—	—	—
Scottish Enterprise agreement	—	—	20	20
Other liabilities measured at fair value	—	—	20	20
Total liabilities	—	—	1,140	1,140

Schedule of reconciliation of the beginning and ending balance of Level 3 inputs

The following table reconciles the beginning and ending balances of Level 3 inputs for the year ended December 31, 2012:

	Level 3
	$000
Balance as of December 31, 2011	71
Sale of Economic Rights	1,097
Change in valuation of Economic Rights	23
Change in valuation of warrants liability	(51	)
Balance as of December 31, 2012	1,140

Schedule of assumptions used to value the economic Rights

		December 31,
		2012
Probability of unsuccessful/successful outcomes		25% - 75%
Amount of award or settlement (1)		$10.0 million - $20.0 million
Discount rate		17.5%
Timing of cash flows		0.75 — 1.50 years
Royalty rate		6%
Litigation expenses		$3.0 million

(1) Assumptions take into consideration the cap on the amount that the Company would have to pay investors in the event of an award or settlement.

- Definition

Tabular disclosure of the fair value measurement of liabilities using significant unobservable inputs (Level 3), a reconciliation of the beginning and ending balances, separately presenting changes attributable to the following: (1) total gains or losses for the period (realized and unrealized), segregating those gains or losses included in earnings (or changes in net assets), and gains or losses recognized in other comprehensive income (loss) and a description of where those gains or losses included in earnings (or changes in net assets) are reported in the statement of income (or activities); (2) purchases, sales, issues, and settlements (each type disclosed separately); and (3) transfers in and transfers out of Level 3 (for example, transfers due to changes in the observability of significant inputs) by class of liability.

+ References + Details

Prepaid Expenses and Other Current Assets (Tables)

12 Months Ended

Dec. 31, 2012

Prepaid Expenses and Other Current Assets

Schedule of prepaid expenses and other current assets

	December 31,
	2011	2012
	$000	$000
Research and development tax credit receivable	544	1,033
Prepayments	317	358
Deposits	—	153
Other current assets	208	55
	1,069	1,599

Property, Plant and Equipment (Tables)

12 Months Ended

Dec. 31, 2012

Property, Plant and Equipment

Schedule of property, plant and equipment

	Useful lives in years from	December 31,
	date of acquisition	2011		2012
		$000		$000
Leasehold improvements	5 to 15 yrs	844		867
Research and laboratory equipment	3 to 5 yrs	6,251		5,519
Office equipment and furniture	3 to 5 yrs	1,273		1,325
		8,368		7,711
Less: accumulated depreciation and amortization		(8,201	)	(7,582	)
		167		129

Accrued and Other Current Liabilities (Tables)

12 Months Ended

Dec. 31, 2012

Accrued and Other Current Liabilities

Schedule of accrued and other current liabilities

	December 31,
	2011	2012
	$000	$000
Accrued research and development	3,471	3,623
Accrued legal and professional fees	232	1,118
Other current liabilities	480	860
	4,183	5,601

Commitments and Contingencies (Tables)

12 Months Ended

Dec. 31, 2012

Commitments and Contingencies

Schedule of the Company's contractual obligations and commitments relating to entity's facilities leases

The following is a summary of the Company’s contractual obligations and commitments relating to its facilities leases as at December 31, 2012:

		Operating lease obligations
		$000
2013		584
2014		584
2015		572
2016		567
2017		439
Thereafter		3,223
Total		5,969

Stockholders' Equity (Tables)

12 Months Ended

Dec. 31, 2012

Stockholders' Equity

Schedule of redemption prices per share

Year from November 1, 2012 to October 31, 2013	$	10.12
Year from November 1, 2013 to October 31, 2014	$	10.06
November 1, 2014 and thereafter	$	10.00

Schedule of conversion of convertible preferred stock

		Year ended December 31, 2010
Preferred shares exchanged		833,671
Common shares issued:
At stated convertible option		50,679
Incremental shares issued under the exchange transaction		185,835
Total common shares issued		236,514

Schedule of warrants outstanding

The following table summarizes information about warrants outstanding at December 31, 2012:

Issued in Connection With	Expiration Date	Common Shares Issuable	Weighted Average Exercise Price
April 2006 stock issuance	2013	367,347	$	49.00
February 2007 stock issuance	2014	151,773	$	59.08
December 2007 CEFF	2013	14,285	$	9.80
July 2009 Series II stock issuance	2014	98,893	$	7.00
January 2010 stock issuance	2015	101,785	$	22.82
January 2010 stock issuance	2015	100,714	$	19.95
October 2010 stock issuance	2015	594,513	$	13.44
July 2011 stock issuance	2016	544,117	$	9.52
Total		1,973,427	$	22.96

- Definition

Tabular disclosure of warrants or rights issued. Warrants and rights outstanding are derivative securities that give the holder the right to purchase securities (usually equity) from the issuer at a specific price within a certain time frame. Warrants are often included in a new debt issue to entice investors by a higher return potential. The main difference between warrants and call options is that warrants are issued and guaranteed by the company, whereas options are exchange instruments and are not issued by the company. Also, the lifetime of a warrant is often measured in years, while the lifetime of a typical option is measured in months. Disclose the title of issue of securities called for by warrants and rights outstanding, the aggregate amount of securities called for by warrants and rights outstanding, the date from which the warrants or rights are exercisable, and the price at which the warrant or right is exercisable.

+ References + Details

Stock-Based Compensation Arrangements (Tables)

12 Months Ended

Dec. 31, 2012

Stock-Based Compensation Arrangements

Schedule of stock based compensation expense

	Year ended December 31, 2010	Year ended December 31, 2011	Year ended December 31, 2012
	$000	$000	$000
Research and development	351	171	71
General and administrative	1,344	669	266
(Loss) income from discontinued operations, net of tax	51	42	43
Stock-based compensation costs before income taxes	1,746	882	380

Schedule of stock option activity

Cyclacel Pharmaceuticals, Inc.	Number of options outstanding		Weighted average exercise price		Weighted average remaining contractual term (years)	Aggregate intrinsic value
Options outstanding at December 31, 2010	498,562		$	27.72	7.22	$	938
Granted	28,500		$	10.64
Exercised	(948	)	$	2.87
Cancelled/forfeited	(23,865	)	$	40.53
Options outstanding at December 31, 2011	502,249		$	26.11	6.44	$	140
Granted	33,571		$	3.29
Exercised	(33,351	)	$	3.09
Cancelled/forfeited	(39,446	)	$	20.21
Options outstanding at December 31, 2012	463,023		$	26.61	5.58	347
Unvested at December 31, 2011	69,781		$	8.83	8.44	68
Vested and exercisable at December 31, 2012	393,242		$	29.77	5.07	279

Schedule of information about options outstanding

The following table summarizes information about options outstanding at December 31, 2012:

Exercise price ($)	Number outstanding	Weighted Average remaining contractual life	Number exercisable
2.03 — 13.86	196,078	7.24	133,108
15.05 — 34.62	44,618	6.11	37,807
36.63 — 40.67	72,581	4.81	72,581
43.75 — 48.65	123,353	3.56	123,353
54.60 — 105.00	26,393	3.88	26,393
	463,023		393,242

Schedule of assumptions for stock option grants to employees and directors

	Year ended December 31, 2010	Year ended December 31, 2011	Year ended December 31, 2012
Expected term (years)	5 — 6	5 — 6	6
Risk free interest rate	1.64 — 2.96%	1.47 — 2.29%	0.95%
Volatility	90 — 102%	93 — 99%	98%
Expected dividend yield over expected term	0.00%	0.00%	0.00%
Resulting weighted average grant date fair value	$9.80	$8.05	$2.52

Schedule of restricted stock activity

	Restricted Stock		Weighted Average Grant Date Value Per Share
Non-vested at December 31, 2010	3,418		$	3.08
Vested	(1,786	)	$	3.08
Non-vested at December 31, 2011	1,632		$	3.08
Vested	(1,632	)	$	3.08
Non-vested at December 31, 2012	—		$	—

Schedule of restricted stock units activity

	Restricted Stock Units		Weighted Average Grant Date Value Per Share
Non-vested at December 31, 2010	5,142		$	3.08
Granted	34,000		$	5.81
Vested	(2,679	)	$	3.08
Non-vested at December 31, 2011	36,463		$	5.60
Granted	12,281		$	3.85
Forfeited	(6,904	)	$	4.99
Vested	(2,463	)	$	3.08
Non-vested at December 31, 2012	39,377		$	5.34

- Definition

Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed.

+ References + Details

Taxes (Tables)

12 Months Ended

Dec. 31, 2012

Taxes

Schedule of components of (loss) gain before taxes from continuing operations

	Year ended December 31, 2010		Year ended December 31, 2011		Year ended December 31, 2012
	$000		$000		$000
Domestic	(3,533	)	904		(2,009	)
Foreign	(12,014	)	(16,072	)	(13,098	)
(Loss) gain from continuing operations before taxes	(3,533	)	(15,168	)	(15,107	)

Schedule of benefit for income taxes from continuing operations

	Year ended December 31, 2010		Year ended December 31, 2011	Year ended December 31, 2012
	$000		$000	$000
Current — domestic	(10	)	—	—
Current — foreign	667		565	1,014
Current — total	657		565	1,014
Deferred — domestic	—		—	337
Income tax benefit	657		565		1,351

Schedule of reconciliation of the (benefit) provision for income taxes from continuing operations with the amount computed by applying the statutory federal tax rate to loss before income taxes

	Year ended December 31, 2010		Year ended December 31, 2011		Year ended December 31, 2012
	$000		$000		$000
Loss before income taxes	(15,547	)	(15,168	)	(15,107	)

Income tax expense computed at statutory federal tax rate	(5,286	)	(5,157	)	(5,136	)
Disallowed expenses and non-taxable income	(490	)	(141	)	176
Loss surrendered to generate R&D credit	1,605		1,372		3,025
Additional research and development tax relief	(793	)	(2,260	)	(2,656	)
Change in valuation allowance	3,605		2,952		(579	)
Research and development tax credit rate difference	132		—		—
Foreign items, including change in tax rates	570		2,669		3,819
	(657	)	(565	)	(1,351	)

Schedule of significant components of the entity's deferred tax assets

	December 31,
	2011		2012
	$000		$000
Net operating loss carryforwards	43,870		42,399
Depreciation, amortization and impairment of property and equipment	1,772		1,654
Stock Options	1,372		1,451
Accrued Expenses	3,435		3,389
Other	96		45
Translation adjustment	249		1,277
Deferred Tax Assets	50,794		50,215
Valuation allowance for deferred tax assets	(50,794	)	(50,215	)
Net deferred taxes	—		—

Schedule of tax losses and accumulated tax losses available for carry forward against future operations

	December 31,
	2011	2012
	$000	$000
Accumulated tax losses	148,274	153,424

Geographic Information (Tables)

12 Months Ended

Dec. 31, 2012

Geographic Information

Schedule of geographic information

	Year ended December 31, 2010		Year ended December 31, 2011		Year ended December 31, 2012
	$000		$000		$000
Revenue
United Kingdom	112		—		69
Total Revenue	1		—		69
Net loss
United States:
Continuing operations	(3,531	)	565		(1,672	)
Discontinued operations	(1,131	)	(640	)	570
Total United States	(4,662	)	(75	)	(1,102	)
United Kingdom	(11,359	)	(15,168	)	(12,084	)
Total Net Loss	(16,021	)	(15,243	)	(13,186	)

	December 31,
	2011	2012
	$000	$000
Total Assets
United States:
Continuing operations	20,402	14,286
Discontinued operations	313	1,214
Total United States	20,715	15,500
United Kingdom	5,283	3,854
Total Assets	25,998	19,354

Long Lived Assets, net
United States:
Continuing operations	45	25
Discontinued operations	—	—
Total United States	45	25
United Kingdom	122	104
Total Long Lived Assets, net	167	129

Organization of the Company (Details)	12 Months Ended
Organization of the Company (Details)	Dec. 31, 2012 item
Nature of Operations
Age criteria for enrollment of patients for front line treatment of sapacitabine oral capsules, minimum	70

Organization of the Company (Details 2) $ / shares in Units, $ in Thousands					1 Months Ended	12 Months Ended
	Dec. 14, 2012 USD ($) shares	Sep. 11, 2012 $ / shares	Aug. 24, 2012	Aug. 10, 2012 USD ($)	Nov. 30, 2012 USD ($)	Dec. 31, 2012 USD ($)
Purchase price for shares issued under purchase agreement						$ 1,418
Grant awarded from UK Government's Biomedical Catalyst					$ 1,900
Reverse stock split conversion ratio			0.143
Minimum
Closing bid price of common stock evidenced by the entity to regain compliance (in dollars per share) \| $ / shares		$ 1.00
Period from NASDAQ Staff's notification, during which the closing bid price of the common stock must equal to or exceed the specified closing bid price to regain compliance		10 days
Aspire Capital Fund, LLC
Number of shares issued under purchase agreement \| shares	158,982
Purchase price for shares issued under purchase agreement	$ 1,000
Shares committed to purchase \| shares	1,455,787
Period of common stock purchase agreement	2 years
Stock issued for non-cash consideration \| shares	74,548
Aspire Capital Fund, LLC \| Maximum
Common stock purchase agreement, purchase commitment	$ 19,000
Sinclair
Period of royalty arrangement				3 years
Sinclair \| Minimum
Quarterly installments receivable under royalty arrangement				$ 1,000

Summary of Significant Accounting Policies (Details)	12 Months Ended			197 Months Ended
Summary of Significant Accounting Policies (Details)	Dec. 31, 2012 USD ($) area segment	Dec. 31, 2011 USD ($)	Dec. 31, 2010 USD ($)	Dec. 31, 2012 USD ($) area
Segments
Number of operating segments \| segment	1
Number of geographic areas for development operations \| area	2			2
Property, plant and equipment
Fixed assets sold		$ 6,000	$ 28,000
Proceeds from sale of property, plant and equipment	$ 62,000	$ 5,000	$ 41,000	$ 225,000
Property, plant and equipment \| Minimum
Property, plant and equipment
Estimated useful life	3 years
Property, plant and equipment \| Maximum
Property, plant and equipment
Estimated useful life	5 years
Leasehold improvements \| Minimum
Property, plant and equipment
Estimated useful life	5 years
Leasehold improvements \| Maximum
Property, plant and equipment
Estimated useful life	15 years

Summary of Significant Accounting Policies (Details 2) $ in Millions	12 Months Ended
	Dec. 31, 2012 USD ($)
Product sales
Percentage of current wholesale acquisition price to be deducted from gross invoice sales price to record deferred revenue	5.00%
Nonrefundable revenue recognized	$ 0.0

Summary of Significant Accounting Policies (Details 3) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Net loss per common share
Total shares excluded from calculation	2,989,949	2,587,516	2,901,948
Taxes recorded on items of other comprehensive income	$ 0.0
Stock options
Net loss per common share
Total shares excluded from calculation	463,023	502,249	498,562
Restricted Stock and Restricted Stock Units
Net loss per common share
Total shares excluded from calculation	39,377	38,089	8,555
Convertible preferred stock
Net loss per common share
Total shares excluded from calculation	73,747	73,747	73,747
Contingently issuable common stock and common stock warrants associated with Economic Rights
Net loss per common share
Total shares excluded from calculation	440,375
Options issued in connection with the October 2010 financing
Net loss per common share
Total shares excluded from calculation			891,771
Common stock warrants
Net loss per common share
Total shares excluded from calculation	1,973,427	1,973,431	1,429,313

- Definition

Securities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) or earnings per unit (EPU) in the future that were not included in the computation of diluted EPS or EPU because to do so would increase EPS or EPU amounts or decrease loss per share or unit amounts for the period presented.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Antidilution
-URI http://asc.fasb.org/extlink&oid=6505113

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Diluted Earnings Per Share
-URI http://asc.fasb.org/extlink&oid=6510752

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Contingent Stock Agreement
-URI http://asc.fasb.org/extlink&oid=6508534

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (c)
-URI http://asc.fasb.org/extlink&oid=6371337&loc=d3e3550-109257

Reference 5: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 128
-Paragraph 40
-Subparagraph c
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 6: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 128
-Paragraph 13, 14
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Emerging Issues Task Force (EITF)
-Number 07-4
-Paragraph 4
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 8: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 128
-Paragraph 171
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

+ Details

- Definition

Tax effect of other comprehensive income (loss) attributable to both parent entity and noncontrolling interest.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 220
-SubTopic 10
-Section 45
-Paragraph 12
-URI http://asc.fasb.org/extlink&oid=20435746&loc=d3e640-108580

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 20
-Section 45
-Paragraph 11
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=18498875&loc=d3e39076-109324

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 109
-Paragraph 36
-Subparagraph b
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Regulation S-X (SX)
-Number 210
-Section 02
-Paragraph 31
-Article 5

Reference 5: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 130
-Paragraph 24
-Subparagraph b
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 6: http://www.xbrl.org/2003/role/presentationRef
-Publisher AICPA
-Name Accounting Research Bulletin (ARB)
-Number 51
-Paragraph 38
-Subparagraph c(3)
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher AICPA
-Name Accounting Principles Board Opinion (APB)
-Number 12
-Paragraph 10
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 8: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Regulation S-X (SX)
-Number 210
-Section 04
-Article 3

+ Details

Discontinued Operations (Details) - USD ($) $ in Thousands	12 Months Ended			197 Months Ended
Discontinued Operations (Details) - USD ($) $ in Thousands	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2012
Reclassification of operating results from continuing operations to loss from discontinued operations
Gain on termination of distribution agreements	$ 1,192			$ 1,192
Income tax expense	337	$ 0	$ 0
(Loss) income from discontinued operations, net of tax	570	(640)	(1,131)	(12,146)
Current assets of discontinued operations:
Total current assets of discontinued operations	861	313		861
Current liabilities of discontinued operations:
Total current liabilities of discontinued operations	335	527		335
Xclair, Numoisyn Lozenges and Numoisyn Liquid
Reclassification of operating results from continuing operations to loss from discontinued operations
Product revenue	583	699	574	3,604
Cost of goods sold	(293)	(360)	(418)	(2,045)
Selling, general and administrative	(607)	(979)	(1,287)	(9,295)
Goodwill and intangible impairment				(5,187)
Interest income	32			32
Interest expense				(110)
Gain on termination of distribution agreements	1,192			1,192
(Loss) income from discontinued operations	907	(640)	(1,131)	(11,809)
Income tax expense	(337)			(337)
(Loss) income from discontinued operations, net of tax	570	(640)	$ (1,131)	(12,146)
Present value of minimum royalty payment arising from the termination and settlement agreement	900
Minimum royalty payments receivable	$ 1,000			1,000
Period of royalty arrangement	3 years
Amount recognized on offsetting product return provision liability	$ 300
Current assets of discontinued operations:
Inventory		182
Short-term portion of minimum royalty arrangement receivable, net	536			536
Returns indemnification receivable	325			325
Accounts receivable and other current assets		131
Total current assets of discontinued operations	861	313		861
Long-term assets of discontinued operations
Long-term portion of minimum royalty arrangement receivable, net	353			353
Total assets of discontinued operations	1,214	313		1,214
Current liabilities of discontinued operations:
Accounts payable	10	46		10
Returns provision	325	202		325
Accrued liabilities and other current liabilities		279
Total current liabilities of discontinued operations	$ 335	$ 527		$ 335

Significant Contracts (Details) $ in Millions	1 Months Ended			12 Months Ended
Significant Contracts (Details) $ in Millions	Jul. 31, 2011 country	Apr. 30, 2011 USD ($)	Oct. 31, 2007 item	Dec. 31, 2012 USD ($)	Dec. 31, 2010 USD ($)	Dec. 31, 2009 USD ($)	Dec. 31, 2011 USD ($)
Daiichi Sankyo
Licensing Agreements
Up-front fee and certain past reimbursements		$ 1.6
Future milestone payments payable				$ 10.0
Period for which royalties will be paid following the first commercial sale of licensed products in the country				10 years
Notice period for termination of license by the entity for technical, scientific, efficacy, safety, or commercial reasons				6 months
Notice period for termination of license after launch of a sapacitabine-based product by the entity, or by either party for material default				12 months
Daiichi Sankyo \| Minimum
Licensing Agreements
Number of countries for which regulatory approval is required by September 2011 to sell sapacitabine as per termination right waived after amendment to the agreement \| country	1
Percentage of increase in royalty due on future net sales of sapacitabine after amendment				1.25%
Daiichi Sankyo \| Maximum
Licensing Agreements
Percentage of increase in royalty due on future net sales of sapacitabine after amendment				1.50%
ALIGN
Licensing Agreements
Number of products for which exclusive rights acquired to sell and distribute products \| item			3
Commitment payments						$ 1.3
Commitment paid					$ 0.7	$ 0.6
Minimum purchase obligation							$ 0.2

Cash and Cash Equivalents (Details) - USD ($) $ in Thousands	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
Cash and Cash Equivalents
Cash	$ 4,090	$ 4,555
Investments with original maturity of less than three months at the time of purchase	12,322	19,894
Total cash and cash equivalents	$ 16,412	$ 24,449	$ 29,495	$ 11,493

- Definition

Amount of currency on hand as well as demand deposits with banks or financial institutions. Includes other kinds of accounts that have the general characteristics of demand deposits. Also includes short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates. Excludes cash and cash equivalents within disposal group and discontinued operation.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Cash
-URI http://asc.fasb.org/extlink&oid=6506951

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section 45
-Paragraph 1
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=6361293&loc=d3e6676-107765

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 230
-SubTopic 10
-Section 45
-Paragraph 4
-URI http://asc.fasb.org/extlink&oid=6943989&loc=d3e3044-108585

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Cash Equivalents
-URI http://asc.fasb.org/extlink&oid=6507016

Reference 5: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02.1)
-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

Reference 6: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Regulation S-X (SX)
-Number 210
-Section 02
-Paragraph 1
-Article 5

Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 95
-Paragraph 7, 26
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 8: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 95
-Paragraph 7
-Footnote 1
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 9: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 95
-Paragraph 8, 9
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

+ Details

Fair Value (Details) - Recurring basis - USD ($) $ in Thousands	Dec. 31, 2012	Dec. 31, 2011
Level 1
ASSETS
Cash equivalents	$ 5,523	$ 19,894
Total assets	5,523	19,894
Level 2
ASSETS
Cash equivalents	6,799
Total assets	6,799
Level 3
LIABILITIES
Economic rights	1,120
Warrants Liability		51
Scottish Enterprise agreement	20	20
Other liabilities measured at fair value	20	71
Total liabilities	1,140	71
Total
ASSETS
Cash equivalents	12,322	19,894
Financial instrument associated with stock purchase agreement	0
Total assets	12,322	19,894
LIABILITIES
Economic rights	1,120
Warrants Liability		51
Scottish Enterprise agreement	20	20
Other liabilities measured at fair value	20	71
Total liabilities	$ 1,140	$ 71

Fair Value (Details 2) - USD ($)				1 Months Ended	9 Months Ended	12 Months Ended		197 Months Ended
Fair Value (Details 2) - USD ($)	Mar. 06, 2013	Dec. 14, 2012	Mar. 22, 2012	Feb. 28, 2007	Dec. 31, 2012	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2012
Reconciliation of the beginning and ending balance of Level 3 inputs
Balance at the beginning of the period						$ 71,000
Balance at the end of the period					$ 1,140,000	1,140,000	$ 71,000	$ 1,140,000
Purchase price for shares issued under purchase agreement						1,418,000
Stock purchase agreement						423,000		423,000
Change in fair value of the derivative						23,000		23,000
Warrants Liability
Value of financial instrument		$ 0			0	0		0
Aspire Capital Fund, LLC
Reconciliation of the beginning and ending balance of Level 3 inputs
Number of shares issued under purchase agreement		158,982
Purchase price for shares issued under purchase agreement		$ 1,000,000
Shares committed to purchase		1,455,787
Period of common stock purchase agreement		2 years
Stock issued for non-cash consideration		74,548
Stock purchase agreement						400,000
Aspire Capital Fund, LLC \| Maximum
Reconciliation of the beginning and ending balance of Level 3 inputs
Common stock purchase agreement, purchase commitment		$ 19,000,000
Economic Rights
Reconciliation of the beginning and ending balance of Level 3 inputs
Sale						(1,097,000)
Change in valuation of liability						(23,000)
Amount to be paid as percentage of future litigation settlement amount received			10.00%
Fair value of the liability					1,100,000	$ 1,100,000		1,100,000
Change in fair value of the derivative					23,000
Warrants Liability
Discount rate (as a percent)						17.50%
Royalty rate (as a percent)						6.00%
Litigation expenses						$ 3,000,000
Stay period	30 days
Economic Rights \| Minimum
Warrants Liability
Expected volatility (as a percent)						25.00%
Amount of award or settlement					10,000,000	$ 10,000,000		10,000,000
Timing of cash flows						9 months
Economic Rights \| Maximum
Warrants Liability
Expected volatility (as a percent)						75.00%
Amount of award or settlement					20,000,000	$ 20,000,000		20,000,000
Timing of cash flows						1 year 6 months
Warrants
Reconciliation of the beginning and ending balance of Level 3 inputs
Change in valuation of liability						$ 51,000	$ (600,000)
Warrants Liability
Expected volatility (as a percent)				85.00%
Fair value of the warrants				$ 6,800,000	$ 0	$ 0		$ 0
Risk free interest rate (as a percent)				4.68%
Expected dividend yield (as a percent)				0.00%
Contractual life				7 years
Expected term						1 year 1 month 17 days

Fair Value (Details 3) - Scottish Enterprise Agreement $ in Thousands, £ in Millions	1 Months Ended	12 Months Ended
	Jun. 30, 2009 tranche	Dec. 31, 2012 USD ($)	Dec. 31, 2011 USD ($)	Dec. 31, 2012 GBP (£)	Dec. 31, 2011 GBP (£)	Jan. 06, 2010 USD ($)	Jan. 06, 2010 GBP (£)	Dec. 31, 2009 USD ($)	Jul. 02, 2009 USD ($)	Jul. 02, 2009 GBP (£)	Jun. 22, 2009 USD ($)	Jun. 22, 2009 GBP (£)
Scottish Enterprise Agreement
Maximum guaranteed amount potentially due to SE		$ 6,500	$ 6,200		£ 4.0			$ 8,000				£ 5.0
Modified payment for which parties agreed											$ 1,700	£ 1.0
Number of tranches in which modified payment will be paid \| tranche	2
Amount paid					4.0	$ 800	£ 0.5		$ 800	£ 0.5
Potential amount to be paid if staffing levels reduced below the prescribed levels		6,100	5,900	£ 3.8	£ 3.8
Fair value of the liability \| $		$ 20	$ 20
Expected volatility (as a percent)		30.00%	30.00%
Probability of falling below a minimum staffing level within prescribed time period (as a percent)		1.00%	1.00%

Prepaid Expenses and Other Current Assets (Details) - USD ($) $ in Thousands	Dec. 31, 2012	Dec. 31, 2011
Prepaid Expenses and Other Current Assets
Research and development tax credit receivable	$ 1,033	$ 544
Prepayments	358	317
Deposits	153
Other current assets	55	208
Total prepaid expenses and other current assets	$ 1,599	$ 1,069

Property, Plant and Equipment (Details) - USD ($)	12 Months Ended			197 Months Ended
Property, Plant and Equipment (Details) - USD ($)	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2012
Property, plant and equipment
Property, plant and equipment, gross	$ 7,711,000	$ 8,368,000		$ 7,711,000
Less: accumulated depreciation and amortization	(7,582,000)	(8,201,000)		(7,582,000)
Property, Plant and Equipment, Net	129,000	167,000	$ 167,000	129,000
Depreciation and amortization
Depreciation and amortization expense	60,000	241,000	$ 457,000	12,615,000
Assets held under capital lease arrangements	0	0		0
Leasehold improvements
Property, plant and equipment
Property, plant and equipment, gross	$ 867,000	844,000		867,000
Leasehold improvements \| Minimum
Property, plant and equipment
Useful lives in years from date of acquisition	5 years
Leasehold improvements \| Maximum
Property, plant and equipment
Useful lives in years from date of acquisition	15 years
Research and laboratory equipment
Property, plant and equipment
Property, plant and equipment, gross	$ 5,519,000	6,251,000		5,519,000
Research and laboratory equipment \| Minimum
Property, plant and equipment
Useful lives in years from date of acquisition	3 years
Research and laboratory equipment \| Maximum
Property, plant and equipment
Useful lives in years from date of acquisition	5 years
Office equipment and furniture
Property, plant and equipment
Property, plant and equipment, gross	$ 1,325,000	$ 1,273,000		$ 1,325,000
Office equipment and furniture \| Minimum
Property, plant and equipment
Useful lives in years from date of acquisition	3 years
Office equipment and furniture \| Maximum
Property, plant and equipment
Useful lives in years from date of acquisition	5 years

Accrued and Other Current Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2012	Dec. 31, 2011
Accrued and Other Current Liabilities
Accrued research and development	$ 3,623	$ 3,471
Accrued legal and professional fees	1,118	232
Other current liabilities	860	480
Total	$ 5,601	$ 4,183

- Definition

Carrying value as of the balance sheet date of obligations incurred through that date and payable for professional fees, such as for legal and accounting services received. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

+ References + Details

- Definition

Carrying value as of the balance sheet date of obligations incurred through that date and payable arising from transactions not otherwise specified in the taxonomy. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

+ References + Details

Commitments and Contingencies (Details) - USD ($) $ in Thousands	1 Months Ended		12 Months Ended
	May 31, 2011	Oct. 31, 2000	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Operating lease obligations
2013			$ 584
2014			584
2015			572
2016			567
2017			439
Thereafter			3,223
Total			5,969
Leases, related disclosures
Rent expense, net			$ 600	$ 600	$ 900
Lease term for research and development facility		25 years
Extended term of lease for office space	5 years
Manufactured products
Purchase Obligations
Purchase obligations with ALIGN				$ 200

Commitments and Contingencies (Details 2) - USD ($) $ / shares in Units, $ in Millions	12 Months Ended
	Dec. 31, 2012	Dec. 31, 2011
Preferred Dividends
Dividend rate (as a percent)	6.00%
Accrued and unpaid dividends in arrears on preferred stock	$ 2.3	$ 1.6
Accrued and unpaid dividends in arrears on preferred stock per share (in dollars per share)	$ 1.90	$ 1.30

Commitments and Contingencies (Details 3) - patent	Mar. 06, 2013	Apr. 27, 2010
Subsequent event
Legal proceedings
Stay period	30 days
Celgene Corporation
Legal proceedings
Number of patents in litigation		4

Stockholders' Equity (Details)	1 Months Ended	12 Months Ended
Stockholders' Equity (Details)	Aug. 31, 2010 director	Dec. 31, 2012 shares Q director $ / shares	Dec. 31, 2011 series $ / shares shares
Stockholders' equity
Preferred stock, shares issued \| shares		1,213,142	1,213,142
Preferred stock, shares outstanding \| shares		1,213,142	1,213,142
Preferred stock, par value (in dollars per share)		$ 0.001	$ 0.001
Dividend rate (as a percent)		6.00%
Number of shares of Preferred Stock exchanged for common stock \| shares		0	0
Year from November 1, 2012 to October 31, 2013
Stockholders' equity
Redemption price per share (in dollars per share)		$ 10.12
Year from November 1, 2013 to October 31, 2014
Stockholders' equity
Redemption price per share (in dollars per share)		10.06
November 1, 2014 and thereafter
Stockholders' equity
Redemption price per share (in dollars per share)		$ 10.00
Debentures
Stockholders' equity
Interest rate (as a percent)		6.00%
Debt principal amount per share, basis for exchange (in dollars per share)		$ 10
Debt instrument, term		25 years
Preferred stock
Stockholders' equity
Preferred stock, shares issued \| shares		1,213,142
Preferred stock, shares outstanding \| shares		1,213,142
Preferred stock, par value (in dollars per share)		$ 10.00
Dividend rate (as a percent)		6.00%
Liquidation preference (in dollars per share)		$ 10
Number of shares to be issued for each preferred stock upon conversion \| shares		0.06079
Conversion price (in dollars per share)		$ 164.50
Shares reserved for future issuance upon conversion \| shares		73,747
Percentage of the closing sales price of the entity's common stock that the conversion price must exceed in order for the preferred stock to be convertible		150.00%
Number of trading days during which the closing price of the entity's common stock must exceed the conversion price for at least 20 days in order for the preferred stock to be convertible		30 days
Number of trading days prior to notice of automatic conversion		5 days
Number of quarters in which no preferred stock dividends have been paid \| Q		6
Number of Board of Directors to be elected by Preferred Stock holders if entity fails to pay dividends on Preferred Stock \| director		2
Number of Board of Directors elected by the Preferred Stock holders when the entity failed to pay dividends on Preferred Stock \| director	2
Preferred stock \| Minimum
Stockholders' equity
Number of series of Preferred Stock \| series			1
Closing price of stock (in dollars per share)		$ 246.75
Number of trading days within 30 trading days in which the closing price of the entity's common stock must exceed the conversion price for the preferred stock to be convertible		20 days

Stockholders' Equity (Details 2) - USD ($) $ in Thousands	12 Months Ended	185 Months Ended	197 Months Ended
Stockholders' Equity (Details 2) - USD ($) $ in Thousands	Dec. 31, 2010	Dec. 31, 2011	Dec. 31, 2012
Stockholders' Equity
Number of shares of Preferred Stock exchanged for common stock		0	0
Common shares issued:
Deemed dividends recorded	$ 3,515		$ 3,515
Preferred stock
Conversion of Convertible Preferred Stock
Preferred shares exchanged (in shares)	833,671	1,776,858
Common stock
Common shares issued:
At stated convertible option (in shares)	50,679
Incremental shares issued under the exchange transaction (in shares)	185,835
Total common shares issued (in shares)	236,514

Stockholders' Equity (Details 3)										3 Months Ended	9 Months Ended	12 Months Ended									197 Months Ended
Stockholders' Equity (Details 3)	Dec. 14, 2012 USD ($) shares	Mar. 22, 2012 USD ($) $ / shares shares	Jul. 07, 2011 USD ($) $ / shares shares	Oct. 07, 2010 USD ($) $ / shares shares	Jan. 25, 2010 USD ($) $ / shares shares	Jan. 13, 2010 USD ($) $ / shares shares	Nov. 24, 2009 USD ($) shares	Jul. 29, 2009 USD ($) $ / shares shares	Feb. 16, 2007 USD ($) shares	Mar. 31, 2010 USD ($) shares	Dec. 31, 2003 shares	Dec. 31, 2012 USD ($) $ / shares shares	Dec. 31, 2011 USD ($) shares	Dec. 31, 2010 USD ($) shares	Dec. 31, 2009 shares	Dec. 31, 2007 shares	Dec. 31, 2004 shares	Mar. 31, 2002 shares	Mar. 31, 2000 shares	Mar. 31, 1998 shares	Dec. 31, 2012 USD ($) $ / shares shares
Common Stock
Purchase price for shares issued under purchase agreement \| $												$ 1,418,000
Non-cash consideration associated with stock purchase agreement \| $												$ 423,000									$ 423,000
Exercise price of warrants (in dollars per share) \| $ / shares												22.96									22.96
Warrants outstanding												1,973,427									1,973,427
Aspire Capital Fund, LLC
Common Stock
Number of shares issued under purchase agreement	158,982
Purchase price for shares issued under purchase agreement \| $	$ 1,000,000
Shares committed to purchase	1,455,787
Period of common stock purchase agreement	2 years
Stock issued for non-cash consideration	74,548
Non-cash consideration associated with stock purchase agreement \| $												$ 400,000
Maximum \| Aspire Capital Fund, LLC
Common Stock
Common stock purchase agreement, purchase commitment \| $	$ 19,000,000
Common stock
Common Stock
Number of shares issued under purchase agreement												233,530
Shares sold (in shares)											215,755		1,088,235	742,857	571,429	607,095	61,510	779	76,984	38,111
Stock issued upon exercise of warrants (in shares)														374,038			3,233
Common stock warrants
Common Stock
Transaction date fair value \| $									$ 6,800,000				$ 100,000
Risk free interest rate (as a percent)									4.58%
Expected volatility (as a percent)									85.00%
Expected dividend yield (as a percent)									0.00%
Contractual life									6 years 10 months 17 days
Number of additional units that can be acquired upon exercise of right									151,773
Change in value of warrants \| $												$ 600,000	600,000
Gains on change in value of warrants \| $												51,000	$ 51,000
December 2012 stock issuance \| Aspire Capital Fund, LLC
Common Stock
Number of shares issued under purchase agreement	158,982
Purchase price for shares issued under purchase agreement \| $	$ 1,000,000
Shares committed to purchase	1,455,787
Period of common stock purchase agreement	2 years
Common stock purchase agreement, purchase commitment \| $	$ 19,000,000
Stock issued for non-cash consideration	74,548
December 2012 stock issuance \| Common stock \| Aspire Capital Fund, LLC
Common Stock
Non-cash consideration associated with stock purchase agreement \| $												$ 400,000
March 2012 Sale of Common Stock and Economic Rights
Common Stock
Net proceeds \| $		$ 2,900,000
Shares sold (in shares)		669,726
Offering price per unit (in dollars per unit) \| $ / shares		$ 4.53
Number of days used to calculate average closing price		10 days
Amount to be paid as percentage of future litigation settlement amount received		10.00%
Lock-up period from the date of issuance		1 year
July 2011 stock issuance
Common Stock
Net proceeds \| $			$ 9,300,000
Offering price per unit (in dollars per unit) \| $ / shares			$ 9.52
Units issued (in shares)			1,088,235
Gross proceeds \| $			$ 10,400,000
Exercise price of warrants (in dollars per share) \| $ / shares												9.52									9.52
Warrants outstanding												544,117									544,117
Underwriting discounts and commissions and other fees and expenses \| $			1,100,000
July 2011 stock issuance \| Common stock
Common Stock
Net proceeds \| $			$ 6,800,000
Number of shares of common stock for each capital unit			1
Net proceeds per share (in dollars per share/warrant/unit) \| $ / shares			$ 6.23
July 2011 stock issuance \| Warrants
Common Stock
Net proceeds \| $			$ 2,500,000
Term of warrants			5 years
Exercise price of warrants (in dollars per share) \| $ / shares			9.52
Period from which warrants or rights are exercisable			6 months
Transaction date fair value \| $			$ 3,500,000
Risk free interest rate (as a percent)			1.74%
Expected volatility (as a percent)			99.00%
Expected dividend yield (as a percent)			0.00%
Contractual life			5 years
Net proceeds per share (in dollars per share/warrant/unit) \| $ / shares			$ 4.62
Number of common shares that can be acquired upon exercise of each warrant			0.5
October 2010 stock issuance
Common Stock
Net proceeds \| $				$ 14,000,000
Offering price per unit (in dollars per unit) \| $ / shares				$ 12.78
Units issued (in shares)				1,189,027
Gross proceeds \| $				$ 15,200,000
Exercise price of warrants (in dollars per share) \| $ / shares												13.44									13.44
Warrants outstanding												594,513									594,513
October 2010 stock issuance \| Common stock
Common Stock
Net proceeds \| $				$ 8,900,000
Number of shares of common stock for each capital unit				1
Net proceeds per share (in dollars per share/warrant/unit) \| $ / shares				$ 7.49
October 2010 stock issuance \| Warrants
Common Stock
Net proceeds \| $				$ 3,300,000
Term of warrants				5 years
Number of common stock purchase warrants for each capital unit				0.5
Exercise price of warrants (in dollars per share) \| $ / shares				13.44
Transaction date fair value \| $				$ 5,100,000
Net proceeds per share (in dollars per share/warrant/unit) \| $ / shares				$ 5.53
Number of common shares that can be acquired upon exercise of each warrant				1
October 2010 stock issuance \| Additional optional units
Common Stock
Net proceeds \| $				$ 1,800,000
Offering price per unit (in dollars per unit) \| $ / shares				$ 11.69
Gross proceeds \| $				$ 6,900,000
Period from which warrants or rights are exercisable				9 months
Transaction date fair value \| $				$ 2,800,000
Net proceeds per share (in dollars per share/warrant/unit) \| $ / shares				$ 3.01
Number of additional units that can be acquired upon exercise of right				594,513
Stock issued upon exercise of warrants (in shares)				0
January 2010 stock issuance, one
Common Stock
Net proceeds \| $					$ 5,400,000
Offering price per unit (in dollars per unit) \| $ / shares					$ 17.50
Units issued (in shares)					335,714
Gross proceeds \| $					$ 5,900,000
Exercise price of warrants (in dollars per share) \| $ / shares												22.82									22.82
Warrants outstanding												101,785									101,785
January 2010 stock issuance, one \| Common stock
Common Stock
Net proceeds \| $					$ 4,500,000
Number of shares of common stock for each capital unit					1
Net proceeds per share (in dollars per share/warrant/unit) \| $ / shares					$ 13.51
January 2010 stock issuance, one \| Warrants
Common Stock
Net proceeds \| $					$ 900,000
Term of warrants					5 years
Number of common stock purchase warrants for each capital unit					1
Exercise price of warrants (in dollars per share) \| $ / shares					19.95
Period from which warrants or rights are exercisable					6 months
Transaction date fair value \| $					$ 1,000,000
Risk free interest rate (as a percent)					2.39%
Expected volatility (as a percent)					90.00%
Expected dividend yield (as a percent)					0.00%
Contractual life					5 years
Net proceeds per share (in dollars per share/warrant/unit) \| $ / shares					$ 9.03
Number of common shares that can be acquired upon exercise of each warrant					0.30
January 2010 stock issuance, two
Common Stock
Net proceeds \| $						$ 6,500,000
Offering price per unit (in dollars per unit) \| $ / shares						$ 17.57
Units issued (in shares)						407,143
Gross proceeds \| $						$ 7,200,000
Exercise price of warrants (in dollars per share) \| $ / shares												19.95									19.95
Warrants outstanding												100,714									100,714
January 2010 stock issuance, two \| Common stock
Common Stock
Net proceeds \| $						$ 5,600,000
Number of shares of common stock for each capital unit						1
Net proceeds per share (in dollars per share/warrant/unit) \| $ / shares						$ 13.65
January 2010 stock issuance, two \| Warrants
Common Stock
Net proceeds \| $						$ 900,000
Term of warrants						5 years
Number of common stock purchase warrants for each capital unit						1
Exercise price of warrants (in dollars per share) \| $ / shares						22.82
Period from which warrants or rights are exercisable						6 months
Transaction date fair value \| $						$ 1,300,000
Risk free interest rate (as a percent)						2.55%
Expected volatility (as a percent)						90.00%
Expected dividend yield (as a percent)						0.00%
Contractual life						5 years
Net proceeds per share (in dollars per share/warrant/unit) \| $ / shares						$ 9.24
Number of common shares that can be acquired upon exercise of each warrant						0.25
July 2009 Series II stock issuance
Common Stock
Offering price per unit (in dollars per unit) \| $ / shares								$ 5.95
Units issued (in shares)								571,429
Exercise price of warrants (in dollars per share) \| $ / shares												7.00									7.00
Warrants outstanding												98,893									98,893
July 2009 Series II stock issuance \| Common stock
Common Stock
Number of shares of common stock for each capital unit								1
July 2009 Series II stock issuance \| Warrants
Common Stock
Net proceeds \| $								$ 2,900,000
July 2009 Series II stock issuance \| Series I Warrant
Common Stock
Term of warrants								7 months
Number of common stock purchase warrants for each capital unit								1
Exercise price of warrants (in dollars per share) \| $ / shares								7.00
Period from which warrants or rights are exercisable								6 months
Number of common shares that can be acquired upon exercise of each warrant								0.625
Proceeds from exercise of warrants \| $										$ 2,500,000
July 2009 Series II stock issuance \| Series II Warrant
Common Stock
Term of warrants								5 years
Number of common stock purchase warrants for each capital unit								1
Exercise price of warrants (in dollars per share) \| $ / shares								7.00
Period from which warrants or rights are exercisable								6 months
Warrants outstanding												98,893									98,893
Transaction date fair value \| $								$ 600,000
Risk free interest rate (as a percent)								2.69%
Expected volatility (as a percent)								90.00%
Expected dividend yield (as a percent)								0.00%
Contractual life								5 years
Number of common shares that can be acquired upon exercise of each warrant								0.1838805
Proceeds from exercise of warrants \| $										$ 43,266
Stock issued upon exercise of warrants (in shares)										6,181		0	0
December 2007 CEFF
Common Stock
Exercise price of warrants (in dollars per share) \| $ / shares												9.80									9.80
Warrants outstanding												14,285									14,285
December 2007 CEFF \| Common stock \| Kingsbridge
Common Stock
Net proceeds \| $														$ 4,900,000
Shares sold (in shares)														402,704
Number of common shares committed to be purchased							583,513
Value of common shares committed to be purchased \| $							$ 60,000,000
Period over which common shares are committed to be purchased							3 years

Stockholders' Equity (Details 4)	9 Months Ended	12 Months Ended
Stockholders' Equity (Details 4)	Dec. 31, 2003 USD ($)	Dec. 31, 2012 USD ($) $ / shares shares	Dec. 31, 2011 USD ($) shares	Dec. 31, 2007 USD ($)	Mar. 31, 2003 USD ($)	Mar. 31, 2002 USD ($)	Mar. 31, 2000 USD ($)
Warrants outstanding
Warrants outstanding		1,973,427
Weighted Average Exercise Price (in dollars per share) \| $ / shares		22.96
Exercise of Stock Options
Stock option exercised (in shares)		33,351	948
Proceeds from exercise of stock options \| $	$ 115,000	$ 100,000	$ 3,000	$ 163,000	$ 12,000	$ 106,000	$ 40,000
April 2006 stock issuance
Warrants outstanding
Warrants outstanding		367,347
Weighted Average Exercise Price (in dollars per share) \| $ / shares		49.00
February 2007 stock issuance
Warrants outstanding
Warrants outstanding		151,773
Weighted Average Exercise Price (in dollars per share) \| $ / shares		59.08
December 2007 CEFF
Warrants outstanding
Warrants outstanding		14,285
Weighted Average Exercise Price (in dollars per share) \| $ / shares		9.80
July 2009 Series II stock issuance
Warrants outstanding
Warrants outstanding		98,893
Weighted Average Exercise Price (in dollars per share) \| $ / shares		7.00
January 2010 stock issuance, one
Warrants outstanding
Warrants outstanding		101,785
Weighted Average Exercise Price (in dollars per share) \| $ / shares		22.82
January 2010 stock issuance, two
Warrants outstanding
Warrants outstanding		100,714
Weighted Average Exercise Price (in dollars per share) \| $ / shares		19.95
October 2010 stock issuance
Warrants outstanding
Warrants outstanding		594,513
Weighted Average Exercise Price (in dollars per share) \| $ / shares		13.44
July 2011 stock issuance
Warrants outstanding
Warrants outstanding		544,117
Weighted Average Exercise Price (in dollars per share) \| $ / shares		9.52

Stock-Based Compensation Arrangements (Details)	12 Months Ended
Stock-Based Compensation Arrangements (Details)	Dec. 31, 2012	Dec. 31, 2010
Stock-based compensation
Vesting period	4 years
Percentage of the award vesting one year from the date of grant	0.25
Period for vesting of one-fourth award	1 year
Percentage of the award vesting each month after one year	0.0208
Percentage of the award vesting each month		0.0208
Executive officers \| Minimum
Stock-based compensation
Vesting period	3 years
Executive officers \| Maximum
Stock-based compensation
Vesting period	5 years

Stock-Based Compensation Arrangements (Details 2) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Stock-based compensation
Stock-based compensation costs before income taxes	$ 380	$ 882	$ 1,746
(Loss) income from discontinued operations, net of tax
Stock-based compensation
Stock-based compensation costs before income taxes	43	42	51
Research and development
Stock-based compensation
Stock-based compensation costs before income taxes	71	171	351
General and administrative
Stock-based compensation
Stock-based compensation costs before income taxes	$ 266	$ 669	$ 1,344

- Definition

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

+ References + Details

Stock-Based Compensation Arrangements (Details 3) - USD ($)	12 Months Ended			197 Months Ended
	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2012	May 23, 2012
Stock-based compensation
Number of shares reserved for issuance					10,000,000
Number of shares reserved for issuance before amendment					5,200,000
Vesting period	4 years
Compensation cost	$ 380,000	$ 882,000	$ 1,746,000
Cash proceeds	$ 94,000	$ 3,000		$ 267,000
Number of options outstanding
Exercised (in shares)	(33,351)	(948)
Stock options
Stock-based compensation
Expiration period	10 years
Vesting period	4 years
Weighted average grant-date fair value (in dollars per share)	$ 2.52	$ 8.05	$ 9.80
Total remaining unrecognized compensation cost	$ 400,000			$ 400,000
Weighted-average remaining requisite service period of recognition of unrecognized compensation cost	2 years 3 months 7 days
Cash proceeds	$ 100,000	$ 3,000	$ 100,000
Total intrinsic value of options exercised	100,000	7,000	200,000
Income tax benefits recorded for share based payments	$ 0	$ 0	$ 0
Number of options outstanding
Options outstanding at the beginning of the period (in shares)	502,249	498,562
Granted (in shares)	33,571	28,500
Exercised (in shares)	(33,351)	(948)	(24,901)
Cancelled / forfeited (in shares)	(39,446)	(23,865)
Options outstanding at the end of the period (in shares)	463,023	502,249	498,562	463,023
Unvested at the end of the period (in shares)	69,781			69,781
Vested and exercisable at the end of the period (in shares)	393,242			393,242
Weighted average exercise price
Options outstanding at the beginning of the period (in dollars per share)	$ 26.11	$ 27.72
Granted (in dollars per share)	3.29	10.64
Exercised (in dollars per share)	3.09	2.87
Cancelled / forfeited (in dollars per share)	20.21	40.53
Options outstanding at the end of the period (in dollars per share)	26.61	$ 26.11	$ 27.72	$ 26.61
Unvested at the end of the period (in dollars per share)	8.83			8.83
Vested and exercisable at the end of the period (in dollars per share)	$ 29.77			$ 29.77
Weighted average remaining contractual term
Options outstanding	5 years 6 months 29 days	6 years 5 months 8 days	7 years 2 months 19 days
Unvested at the end of the period	8 years 5 months 8 days
Vested and exercisable at the end of the period	5 years 25 days
Aggregate intrinsic value
Options outstanding	$ 347	$ 140	$ 938	$ 347
Unvested at the end of the period	68			68
Vested and exercisable at the end of the period	279			$ 279
Stock options \| Employees and directors
Stock-based compensation
Grant date fair value	100,000	200,000	600,000
Compensation cost	$ 12,000	$ 24,000	$ 50,000
Weighted average grant-date fair value (in dollars per share)	$ 2.52	$ 8.05	$ 9.80
Number of options outstanding
Granted (in shares)	33,571	28,500	100,000

Stock-Based Compensation Arrangements (Details 4)	12 Months Ended
Stock-Based Compensation Arrangements (Details 4)	Dec. 31, 2012 $ / shares shares
Stock-based compensation
Number outstanding (in shares)	463,023
Number exercisable (in shares)	393,242
$2.03 - $13.86
Stock-based compensation
Low end of the range (in dollars per share) \| $ / shares	$ 2.03
High end of the range (in dollars per share) \| $ / shares	$ 13.86
Number outstanding (in shares)	196,078
Weighted Average remaining contractual life	7 years 2 months 26 days
Number exercisable (in shares)	133,108
$15.05 - $34.62
Stock-based compensation
Low end of the range (in dollars per share) \| $ / shares	$ 15.05
High end of the range (in dollars per share) \| $ / shares	$ 34.62
Number outstanding (in shares)	44,618
Weighted Average remaining contractual life	6 years 1 month 10 days
Number exercisable (in shares)	37,807
$36.63 - $40.67
Stock-based compensation
Low end of the range (in dollars per share) \| $ / shares	$ 36.63
High end of the range (in dollars per share) \| $ / shares	$ 40.67
Number outstanding (in shares)	72,581
Weighted Average remaining contractual life	4 years 9 months 22 days
Number exercisable (in shares)	72,581
$43.75 - $48.65
Stock-based compensation
Low end of the range (in dollars per share) \| $ / shares	$ 43.75
High end of the range (in dollars per share) \| $ / shares	$ 48.65
Number outstanding (in shares)	123,353
Weighted Average remaining contractual life	3 years 6 months 22 days
Number exercisable (in shares)	123,353
$54.60 - $105.00
Stock-based compensation
Low end of the range (in dollars per share) \| $ / shares	$ 54.60
High end of the range (in dollars per share) \| $ / shares	$ 105.00
Number outstanding (in shares)	26,393
Weighted Average remaining contractual life	3 years 10 months 17 days
Number exercisable (in shares)	26,393

Stock-Based Compensation Arrangements (Details 5)	1 Months Ended		12 Months Ended
Stock-Based Compensation Arrangements (Details 5)	Feb. 29, 2012 shares	Nov. 30, 2008 shares	Dec. 31, 2012 USD ($) security $ / shares shares	Dec. 31, 2011 USD ($) $ / shares shares	Dec. 31, 2010 USD ($) $ / shares shares
Stock based compensation, additional disclosures
Percentage of the award vesting one year from the date of grant			0.25
Period for vesting of one-fourth award			1 year
Percentage of the award vesting each month after one year			0.0208
Vesting period			4 years
Stock options
Fair value of the stock options granted calculated using Black-Scholes option-pricing model assumptions
Expected term			6 years
Risk free interest rate (as a percent)			0.95%
Volatility (as a percent)			98.00%
Expected dividend yield over expected term (as a percent)			0.00%	0.00%	0.00%
Resulting weighted average grant fair value (in dollars per share) \| $ / shares			$ 2.52	$ 8.05	$ 9.80
Stock based compensation, additional disclosures
Income (expense) recognized due to revision of forfeiture rate \| $			$ 100,000	$ (200,000)	$ (500,000)
Number of Federal Reserve securities whose weighted average is used for calculation of weighted average risk-free interest rate \| security			2
Weighted-average remaining requisite service period of recognition of unrecognized compensation cost			2 years 3 months 7 days
Vesting period			4 years
Stock options \| Minimum
Fair value of the stock options granted calculated using Black-Scholes option-pricing model assumptions
Expected term				5 years	5 years
Risk free interest rate (as a percent)				1.47%	1.64%
Volatility (as a percent)				93.00%	90.00%
Stock based compensation, additional disclosures
Forfeiture rate (as a percent)			0.00%
Stock options \| Maximum
Fair value of the stock options granted calculated using Black-Scholes option-pricing model assumptions
Expected term				6 years	6 years
Risk free interest rate (as a percent)				2.29%	2.96%
Volatility (as a percent)				99.00%	102.00%
Stock based compensation, additional disclosures
Forfeiture rate (as a percent)			30.00%
Restricted Stock
Stock based compensation, additional disclosures
Period for vesting of one-fourth award		1 year
Percentage of the award vesting each month after one year		0.0208
Total remaining unrecognized compensation cost \| $			$ 0
Nonvested activity
Non-vested at the beginning of the period (in shares) \| shares			1,632	3,418
Granted (in shares) \| shares		7,142
Vested (in shares) \| shares			(1,632)	(1,786)
Non-vested at the end of the period (in shares) \| shares				1,632	3,418
Weighted Average Grant Date Value Per Share
Non-vested at the beginning of the period (in dollars per share) \| $ / shares			$ 3.08	$ 3.08
Vested (in dollars per share) \| $ / shares			$ 3.08	3.08
Non-vested at the end of the period (in dollars per share) \| $ / shares				$ 3.08	$ 3.08
Restricted Stock Units
Stock based compensation, additional disclosures
Total remaining unrecognized compensation cost \| $			$ 100,000
Weighted-average remaining requisite service period of recognition of unrecognized compensation cost			1 year 11 months 19 days
Vesting period	3 years	4 years		3 years
Nonvested activity
Non-vested at the beginning of the period (in shares) \| shares			36,463	5,142
Granted (in shares) \| shares	12,281	13,100	12,281	34,000
Forfeited (in shares) \| shares			(6,904)
Vested (in shares) \| shares			(2,463)	(2,679)
Non-vested at the end of the period (in shares) \| shares			39,377	36,463	5,142
Weighted Average Grant Date Value Per Share
Non-vested at the beginning of the period (in dollars per share) \| $ / shares			$ 5.60	$ 3.08
Granted (in dollars per share) \| $ / shares			3.85	5.81
Forfeited (in dollars per share) \| $ / shares			4.99
Vested (in dollars per share) \| $ / shares			3.08	3.08
Non-vested at the end of the period (in dollars per share) \| $ / shares			$ 5.34	$ 5.60	$ 3.08

Employee Benefit Plans (Details)	12 Months Ended
Employee Benefit Plans (Details)	Dec. 31, 2012 USD ($) item	Dec. 31, 2011 USD ($)	Dec. 31, 2010 USD ($)	Dec. 31, 2009 USD ($)
Pension Plan
Employee benefit plans
Contribution made by the entity under the pension plan	$ 100,000	$ 100,000		$ 200,000
401 (k) Plan
Employee benefit plans
Matching contribution by employer as a percentage of the employee's deferral	100.00%
Matching contribution by employer as a percentage of U.S. employee's qualifying compensation	6.00%
Statutorily prescribed annual limit of contributions made by an employee before attaining specified age	$ 17,000
Statutorily prescribed annual limit of contributions made by an employee after attaining specified age	$ 22,500
Specified age limit of employees for calculation of statutorily prescribed annual limit of contribution \| item	50
Contribution made by the entity under the 401(k) Plan	$ 100,000	$ 100,000	$ 100,000

Taxes (Details) - USD ($)	12 Months Ended			197 Months Ended
Taxes (Details) - USD ($)	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2012
Loss (income) from continuing operations before taxes
Domestic	$ (2,009,000)	$ 904,000	$ (3,533,000)
Foreign	(13,098,000)	(16,072,000)	(12,014,000)
(Loss) income from continuing operations before taxes	(15,107,000)	(15,168,000)	(15,547,000)	$ (274,384,000)
Benefit for income taxes from continuing operations
Current - domestic			(10,000)
Current - foreign	1,014,000	565,000	667,000
Current - total	1,014,000	565,000	657,000
Deferred - domestic	337,000
Income tax benefit	1,351,000	565,000	657,000	19,795,000
Research and development \| U.K
Taxes
Income tax credits	$ 0	$ 600,000	$ 700,000	$ 0

Taxes (Details 2) - USD ($)	12 Months Ended			197 Months Ended
Taxes (Details 2) - USD ($)	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2012
Reconciliation of the (benefit) provision for income taxes
Loss before income taxes	$ (15,107,000)	$ (15,168,000)	$ (15,547,000)
Income tax expense computed at statutory federal tax rate	(5,136,000)	(5,157,000)	(5,286,000)
Disallowed expenses and non-taxable income	176,000	(141,000)	(490,000)
Loss surrendered to generate R&D credit	3,025,000	1,372,000	1,605,000
Additional research and development tax relief	(2,656,000)	(2,260,000)	(793,000)
Change in valuation allowance	(579,000)	2,952,000	3,605,000
Research and development tax credit rate difference			132,000
Foreign items, including change in tax rates	3,819,000	2,669,000	570,000
Current - total	(1,351,000)	(565,000)	$ (657,000)	$ (19,795,000)
Significant components of the entity's deferred tax assets
Net operating loss carryforwards	42,399,000	43,870,000		42,399,000
Depreciation, amortization and impairment of property and equipment	1,654,000	1,772,000		1,654,000
Stock Options	1,451,000	1,372,000		1,451,000
Accrued Expenses	3,389,000	3,435,000		3,389,000
Other	45,000	96,000		45,000
Translation adjustment	1,277,000	249,000		1,277,000
Deferred Tax Assets	50,215,000	50,794,000		50,215,000
Valuation allowance for deferred tax assets	(50,215,000)	(50,794,000)		(50,215,000)
Taxes
Material uncertain tax positions	0	0		0
Federal
Taxes
NOLs carryforward	19,200,000	18,600,000		19,200,000
Foreign
Taxes
NOLs carryforward	153,400,000	$ 148,200,000		153,400,000
State
Taxes
NOLs carryforward	$ 18,300,000			$ 18,300,000

Geographic Information (Details) - USD ($) $ in Thousands	8 Months Ended	9 Months Ended	12 Months Ended															185 Months Ended	194 Months Ended	197 Months Ended
Geographic Information (Details) - USD ($) $ in Thousands	Mar. 31, 1997	Dec. 31, 2003	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009	Dec. 31, 2008	Dec. 31, 2007	Dec. 31, 2006	Dec. 31, 2005	Dec. 31, 2004	Mar. 31, 2003	Mar. 31, 2002	Mar. 31, 2001	Mar. 31, 2000	Mar. 31, 1999	Mar. 31, 1998	Dec. 31, 2011	Sep. 30, 2012	Dec. 31, 2012
Geographic information
Revenue			$ 69		$ 112															$ 6,817
Net loss	$ (290)	$ (14,977)	(13,186)	$ (15,243)	(16,021)	$ (19,570)	$ (40,386)	$ (24,053)	$ (29,258)	$ (18,048)	$ (22,742)	$ (15,542)	$ (14,853)	$ (10,382)	$ (5,686)	$ (3,964)	$ (2,534)	$ (253,549)	$ (261,971)	(266,735)
Total Assets			19,354	25,998														25,998		19,354
Long Lived Assets, net			129	167	167													167		129
United States
Geographic information
Net loss			(1,102)	(75)	(4,662)
Total Assets			15,500	20,715														20,715		15,500
Long Lived Assets, net			25	45														45		25
United States \| Continuing operations
Geographic information
Net loss			(1,672)	565	(3,531)
Total Assets			14,286	20,402														20,402		14,286
Long Lived Assets, net			25	45														45		25
United States \| Discontinued operations
Geographic information
Net loss			570	(640)	(1,131)
Total Assets			1,214	313														313		1,214
United Kingdom
Geographic information
Revenue			69		112
Net loss			(12,084)	(15,168)	$ (11,359)
Total Assets			3,854	5,283														5,283		3,854
Long Lived Assets, net			$ 104	$ 122														$ 122		$ 104

- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

+ References

+ Details

Subsequent Events (Details) $ / shares in Units, $ in Thousands			3 Months Ended	12 Months Ended		185 Months Ended	197 Months Ended
	Jan. 11, 2013 $ / shares	Dec. 14, 2012 USD ($) shares	Mar. 31, 2013 USD ($) item shares	Dec. 31, 2012 USD ($) shares	Dec. 31, 2010 USD ($) shares	Dec. 31, 2011 shares	Dec. 31, 2012 USD ($) shares
Subsequent events
Preferred stock, shares outstanding				1,213,142		1,213,142	1,213,142
Deemed dividend \| $					$ 3,515		$ 3,515
Purchase price for shares issued under purchase agreement \| $				$ 1,418
Aspire Capital Fund, LLC
Subsequent events
Number of shares issued under purchase agreement		158,982
Purchase price for shares issued under purchase agreement \| $		$ 1,000
Preferred stock
Subsequent events
Preferred shares exchanged (in shares)					833,671	1,776,858
Preferred stock, shares outstanding				1,213,142			1,213,142
Common stock
Subsequent events
Number of shares issued upon conversion					236,514
Subsequent event \| Preferred stock
Subsequent events
Cash dividend declared per share (in dollars per share) \| $ / shares	$ 0.15
Number of securities exchange agreements \| item			3
Preferred shares exchanged (in shares)			792,460
Preferred stock, shares outstanding			420,862
Deemed dividend \| $			$ 8,400
Subsequent event \| Common stock
Subsequent events
Number of shares issued upon conversion			1,513,653
Excess number of shares issued upon conversion			1,465,480
Subsequent event \| Common stock \| Aspire Capital Fund, LLC
Subsequent events
Number of shares issued under purchase agreement			650,000
Purchase price for shares issued under purchase agreement \| $			$ 3,400

Label	Element	Value
Stock Issued During Period, Value, New Issues	us-gaap_StockIssuedDuringPeriodValueNewIssues	$ 1,000
Accumulated Other Comprehensive Income (Loss) [Member]
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax, Portion Attributable to Parent	us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent	(4,000)
Retained Earnings [Member]
Net Income (Loss) Attributable to Parent	us-gaap_NetIncomeLoss	(290,000)
Comprehensive Income [Member]
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax, Portion Attributable to Parent	us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent	(4,000)
Net Income (Loss) Attributable to Parent	us-gaap_NetIncomeLoss	(290,000)
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent	us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent	(294,000)
Additional Paid-in Capital [Member]
Stock Issued During Period, Value, New Issues	us-gaap_StockIssuedDuringPeriodValueNewIssues	$ 1,000

- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

Net of tax amount of other comprehensive income (loss) attributable to the parent entity.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 810
-SubTopic 10
-Section 50
-Paragraph 1A
-Subparagraph (c)(3)
-URI http://asc.fasb.org/extlink&oid=18733093&loc=SL4573702-111684

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 810
-SubTopic 10
-Section 45
-Paragraph 19
-URI http://asc.fasb.org/extlink&oid=7656940&loc=SL4569616-111683

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 810
-SubTopic 10
-Section 45
-Paragraph 20
-URI http://asc.fasb.org/extlink&oid=7656940&loc=SL4569643-111683

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher AICPA
-Name Accounting Research Bulletin (ARB)
-Number 51
-Paragraph 30
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 5: http://www.xbrl.org/2003/role/presentationRef
-Publisher AICPA
-Name Accounting Research Bulletin (ARB)
-Number 51
-Paragraph 38
-Subparagraph c(3)
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 6: http://www.xbrl.org/2003/role/presentationRef
-Publisher AICPA
-Name Accounting Research Bulletin (ARB)
-Number 51
-Paragraph 29
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

+ Details